7OGJ

Crystal structure of human METTL1 in complex with SAH

Summary for 7OGJ

• Entry DOI: 10.2210/pdb7ogj/pdb
• Descriptor: tRNA (guanine-N(7)-)-methyltransferase, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... (7 entities in total)
• Functional Keywords: mettl1, complex, sah, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 60302.05

Authors

Nai, F.,Bedi, R.K.,Caflisch, A. (deposition date: 2021-05-06, release date: 2021-05-19, Last modification date: 2025-12-10)

• Primary citation: Nai, F.,Flores Espinoza, M.P.,Invernizzi, A.,Vargas-Rosales, P.A.,Bobileva, O.,Herok, M.,Caflisch, A.; Small-Molecule Inhibitors of the m7G-RNA Writer METTL1; Acs Bio Med Chem Au, 2023; DOI: 10.1021/acsbiomedchemau.3c00030

Experimental method

X-RAY DIFFRACTION (1.59 Å)