7OGJ

Crystal structure of human METTL1 in complex with SAH

Summary for 7OGJ

Entry DOI	10.2210/pdb7ogj/pdb
Descriptor	tRNA (guanine-N(7)-)-methyltransferase, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... (7 entities in total)
Functional Keywords	mettl1, complex, sah, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	60302.05
Authors	Nai, F.,Bedi, R.K.,Caflisch, A. (deposition date: 2021-05-06, release date: 2021-05-19, Last modification date: 2023-12-20)
Primary citation	Nai, F.,Flores Espinoza, M.P.,Invernizzi, A.,Vargas-Rosales, P.A.,Bobileva, O.,Herok, M.,Caflisch, A. Small-Molecule Inhibitors of the m7G-RNA Writer METTL1 Acs Bio Med Chem Au, 2023 Cited by DOI: 10.1021/acsbiomedchemau.3c00030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.59 Å)

Structure validation