7OGJ

Crystal structure of human METTL1 in complex with SAH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	tRNA (guanine-N(7)-)-methyltransferase	polymer	252	29178.3	2	UniProt (Q9UBP6) Pfam (PF02390) In PDB	Homo sapiens (human)	Methyltransferase-like protein 1,mRNA (guanine-N(7)-)-methyltransferase,miRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine(46)-N(7))-methyltransferase,tRNA(m7G46)-methyltransferase
2	A, B	GLYCEROL	non-polymer		92.1	8	Chemie (GOL)
3	A, B	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
4	A	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7		water	water		18.0	581	Chemie (HOH)

Sequence modifications

A, B: 2 - 235 (UniProt: Q9UBP6)

PDB	External Database	Details
Met -16	-	initiating methionine
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Arg -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58356.7
Non-Polymers*	Number of molecules	15
	Total formula weight	1945.4
All*	Total formula weight	60302.1

*Water molecules are not included.