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8C30
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BU of 8c30 by Molmil
Crystal structure of 14-3-3 in complex with PyrinpS242 and a protein/peptide interface fragment
分子名称: 14-3-3 protein sigma, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CALCIUM ION, ...
著者Lau, R, Ottmann, C.
登録日2022-12-23
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献14-3-3/Pyrin complex
To Be Published
8C2Y
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BU of 8c2y by Molmil
14-3-3 in complex with Pyrinp pS242
分子名称: 14-3-3 protein sigma, Pyrin pS242 peptide
著者Lau, R, Ottmann, C, Hann, M.
登録日2022-12-23
公開日2024-01-10
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献14-3-3/Pyrin complex
To Be Published
6YR5
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BU of 6yr5 by Molmil
14-3-3 sigma in complex with hDMX-367 peptide
分子名称: 14-3-3 protein sigma, Protein Mdm4, SULFATE ION
著者Wolter, M, Srdanovic, S, Ottman, C, Warriner, S, Wilson, A.
登録日2020-04-19
公開日2021-11-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study.
Febs J., 2022
6QDS
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BU of 6qds by Molmil
Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide stabilized by semi-synthetic fusicoccane FC-NCPC
分子名称: 14-3-3 protein sigma, CHLORIDE ION, FC-NCPC, ...
著者Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
登録日2019-01-02
公開日2020-01-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
6QDU
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BU of 6qdu by Molmil
Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide inhibited by semi-synthetic fusicoccane FC-NCPC
分子名称: 14-3-3 protein sigma, CHLORIDE ION, FC-NCPC, ...
著者Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
登録日2019-01-02
公開日2020-01-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.632 Å)
主引用文献Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
6QDT
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BU of 6qdt by Molmil
Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
登録日2019-01-02
公開日2020-01-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.702 Å)
主引用文献Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
6QDR
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BU of 6qdr by Molmil
Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C.
登録日2019-01-02
公開日2020-01-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.615 Å)
主引用文献Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Cell Chem Biol, 27, 2020
7O07
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BU of 7o07 by Molmil
14-3-3sigma covalently bound to peptide (chloroacetamide-Cys interaction)
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, Transcriptional coactivator YAP1
著者Somsen, B.A, Ottmann, C.
登録日2021-03-25
公開日2021-10-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Covalent flexible peptide docking in Rosetta.
Chem Sci, 12, 2021
5D2D
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BU of 5d2d by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
分子名称: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ...
著者Stevers, L.M, Leysen, S.F.R, Ottmann, C.
登録日2015-08-05
公開日2016-03-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
4IHL
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BU of 4ihl by Molmil
Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
分子名称: (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ...
著者Molzan, M, Ottmann, C.
登録日2012-12-19
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
5D3F
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BU of 5d3f by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A
分子名称: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN
著者Stevers, L.M, Leysen, S.F.R, Ottmann, C.
登録日2015-08-06
公開日2016-03-16
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
4IEA
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BU of 4iea by Molmil
14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide
分子名称: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase
著者Molzan, M, Ottmann, C.
登録日2012-12-13
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
1O9C
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BU of 1o9c by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
分子名称: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION
著者Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
登録日2002-12-12
公開日2003-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9F
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BU of 1o9f by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
分子名称: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE
著者Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
登録日2002-12-12
公開日2003-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9E
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BU of 1o9e by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
分子名称: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN
著者Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
登録日2002-12-12
公開日2003-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9D
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BU of 1o9d by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
分子名称: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE
著者Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
登録日2002-12-12
公開日2003-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
7AYF
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BU of 7ayf by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-110
分子名称: 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, CALCIUM ION, ...
著者Wolter, M, Dijck, L.v, Ottmann, C.
登録日2020-11-12
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AZ2
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BU of 7az2 by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014
分子名称: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ...
著者Wolter, M, Dijck, L.v, Ottmann, C.
登録日2020-11-14
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.081 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AXN
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BU of 7axn by Molmil
14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026
分子名称: 14-3-3 protein sigma, 3-chloranyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ...
著者Wolter, M, Dijck, L.v, Ottmann, C.
登録日2020-11-10
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AOG
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BU of 7aog by Molmil
14-3-3 sigma in complex with Pin1 binding site pS72
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C.
登録日2020-10-14
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AZ1
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BU of 7az1 by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013
分子名称: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ...
著者Wolter, M, Dijck, L.v, Ottmann, C.
登録日2020-11-14
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7B15
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BU of 7b15 by Molmil
14-3-3sigma in complex with SHN3pT869 phosphopeptide crystal structure
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pT869
著者Soini, L, Leysen, S, Davis, J, Ottmann, C.
登録日2020-11-23
公開日2021-09-29
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献14-3-3 sigma in complex with phosphopeptides
To Be Published
7B13
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BU of 7b13 by Molmil
14-3-3sigma in complex with SHN3pS542 phosphopeptide crystal structure
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pS542
著者Soini, L, Leysen, S, Davis, J, Ottmann, C.
登録日2020-11-23
公開日2021-09-29
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献14-3-3 sigma in complex with phosphopeptides
To Be Published
7ZMW
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BU of 7zmw by Molmil
14-3-3s binding to non-natural peptide 2c
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 1
著者Somsen, B.A, Craenmehr, F.W.B, Ottmann, C.
登録日2022-04-19
公開日2022-11-23
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues.
Chem Sci, 13, 2022
7ZMU
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BU of 7zmu by Molmil
14-3-3s binding to non-natural peptide 2d
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 2
著者Somsen, B.A, Craenmehr, F.W.B, Ottmann, C.
登録日2022-04-19
公開日2022-11-23
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues.
Chem Sci, 13, 2022

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