1I07
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![BU of 1i07 by Molmil](/molmil-images/mine/1i07) | EPS8 SH3 DOMAIN INTERTWINED DIMER | 分子名称: | EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8 | 著者 | Kishan, K.V.R, Newcomer, M.E. | 登録日 | 2001-01-29 | 公開日 | 2001-05-09 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Effect of pH and salt bridges on structural assembly: molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain. Protein Sci., 10, 2001
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1I0C
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![BU of 1i0c by Molmil](/molmil-images/mine/1i0c) | EPS8 SH3 CLOSED MONOMER | 分子名称: | EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8 | 著者 | Kishan, K.V.R, Newcomer, M.E. | 登録日 | 2001-01-29 | 公開日 | 2001-05-09 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Effect of pH and salt bridges on structural assembly: molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain. Protein Sci., 10, 2001
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7TTJ
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![BU of 7ttj by Molmil](/molmil-images/mine/7ttj) | Stable-5-LOX elongated Ha2 | 分子名称: | Arachidonate 5-lipoxygenase, FE (II) ION | 著者 | Gilbert, N.C, Newcomer, M.E. | 登録日 | 2022-02-01 | 公開日 | 2022-08-31 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators. J.Biol.Chem., 298, 2022
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7TTL
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![BU of 7ttl by Molmil](/molmil-images/mine/7ttl) | |
1X8J
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![BU of 1x8j by Molmil](/molmil-images/mine/1x8j) | Crystal structure of retinol dehydratase in complex with androsterone and inactive cofactor PAP | 分子名称: | ADENOSINE-3'-5'-DIPHOSPHATE, Androsterone, CALCIUM ION, ... | 著者 | Pakhomova, S, Buck, J, Newcomer, M.E. | 登録日 | 2004-08-18 | 公開日 | 2005-02-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition. Protein Sci., 14, 2005
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1X8L
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![BU of 1x8l by Molmil](/molmil-images/mine/1x8l) | Crystal structure of retinol dehydratase in complex with all-trans-4-oxoretinol and inactive cofactor PAP | 分子名称: | 4-OXORETINOL, ADENOSINE-3'-5'-DIPHOSPHATE, CALCIUM ION, ... | 著者 | Pakhomova, S, Buck, J, Newcomer, M.E. | 登録日 | 2004-08-18 | 公開日 | 2005-02-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition. Protein Sci., 14, 2005
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1X8K
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![BU of 1x8k by Molmil](/molmil-images/mine/1x8k) | Crystal structure of retinol dehydratase in complex with anhydroretinol and inactive cofactor PAP | 分子名称: | ADENOSINE-3'-5'-DIPHOSPHATE, ANHYDRORETINOL, CALCIUM ION, ... | 著者 | Pakhomova, S, Buck, J, Newcomer, M.E. | 登録日 | 2004-08-18 | 公開日 | 2005-02-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition. Protein Sci., 14, 2005
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4OCZ
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![BU of 4ocz by Molmil](/molmil-images/mine/4ocz) | Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea | 分子名称: | 1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morriseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D. | 登録日 | 2014-01-09 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J.Med.Chem., 57, 2014
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4OD0
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![BU of 4od0 by Molmil](/molmil-images/mine/4od0) | Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea | 分子名称: | 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morisseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D. | 登録日 | 2014-01-09 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J.Med.Chem., 57, 2014
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1RBP
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![BU of 1rbp by Molmil](/molmil-images/mine/1rbp) | |
4PAA
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![BU of 4paa by Molmil](/molmil-images/mine/4paa) | Crystal structure of the mature form of rat DMGDH complexed with tetrahydrofolate | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, Dimethylglycine dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Luka, Z, Pakhomova, S, Loukachevitch, L.V, Newcomer, M.E, Wagner, C. | 登録日 | 2014-04-07 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate. Biochem.Biophys.Res.Commun., 449, 2014
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6NS6
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![BU of 6ns6 by Molmil](/molmil-images/mine/6ns6) | Crystal structure of fungal lipoxygenase from Fusarium graminearum. P21 crystal form. | 分子名称: | FE (II) ION, lipoxygenase | 著者 | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | 登録日 | 2019-01-24 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Sci., 28, 2019
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4PAB
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![BU of 4pab by Molmil](/molmil-images/mine/4pab) | Crystal structure of the precursor form of rat DMGDH complexed with tetrahydrofolate | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, Dimethylglycine dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Luka, Z, Pakhomova, S, Loukachevitch, L.V, Newcomer, M.E, Wagner, C. | 登録日 | 2014-04-07 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate. Biochem.Biophys.Res.Commun., 449, 2014
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6NS5
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![BU of 6ns5 by Molmil](/molmil-images/mine/6ns5) | Crystal structure of fungal lipoxygenase from Fusarium graminearum. Second C2 crystal form. | 分子名称: | FE (II) ION, lipoxygenase | 著者 | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | 登録日 | 2019-01-24 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Sci., 28, 2019
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4P9S
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![BU of 4p9s by Molmil](/molmil-images/mine/4p9s) | Crystal structure of the mature form of rat DMGDH | 分子名称: | Dimethylglycine dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Luka, Z, Pakhomova, S, Loukachevitch, L.V, Newcomer, M.E, Wagner, C. | 登録日 | 2014-04-04 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate. Biochem.Biophys.Res.Commun., 449, 2014
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3QUN
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![BU of 3qun by Molmil](/molmil-images/mine/3qun) | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, FomA protein, GLYCEROL, ... | 著者 | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | 登録日 | 2011-02-24 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA. Biochemistry, 50, 2011
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3QUO
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![BU of 3quo by Molmil](/molmil-images/mine/3quo) | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with ATP and fosfomycin | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, FOSFOMYCIN, FomA protein | 著者 | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | 登録日 | 2011-02-24 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA. Biochemistry, 50, 2011
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3QVH
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![BU of 3qvh by Molmil](/molmil-images/mine/3qvh) | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FomA protein | 著者 | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | 登録日 | 2011-02-25 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA. Biochemistry, 50, 2011
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3QVF
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![BU of 3qvf by Molmil](/molmil-images/mine/3qvf) | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgADP and fosfomycin vanadate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FomA protein, MAGNESIUM ION, ... | 著者 | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | 登録日 | 2011-02-25 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA. Biochemistry, 50, 2011
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6NS4
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![BU of 6ns4 by Molmil](/molmil-images/mine/6ns4) | Crystal structure of fungal lipoxygenase from Fusarium graminearum. C2 crystal form. | 分子名称: | ACETATE ION, FE (II) ION, GLYCEROL, ... | 著者 | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | 登録日 | 2019-01-24 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Sci., 28, 2019
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6NS2
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![BU of 6ns2 by Molmil](/molmil-images/mine/6ns2) | Crystal structure of fungal lipoxygenase from Fusarium graminearum. P212121 crystal form. | 分子名称: | FE (II) ION, lipoxygenase | 著者 | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | 登録日 | 2019-01-24 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Sci., 28, 2019
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6NS3
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![BU of 6ns3 by Molmil](/molmil-images/mine/6ns3) | Crystal structure of fungal lipoxygenase from Fusarium graminearum. I222 crystal form. | 分子名称: | FE (II) ION, lipoxygenase | 著者 | Pakhomova, S, Boeglin, W.E, Neau, D.B, Bartlett, S.G, Brash, A.R, Newcomer, M.E. | 登録日 | 2019-01-24 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Sci., 28, 2019
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4NRE
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![BU of 4nre by Molmil](/molmil-images/mine/4nre) | The structure of human 15-lipoxygenase-2 with a substrate mimic | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Arachidonate 15-lipoxygenase B, CALCIUM ION, ... | 著者 | Kobe, M.J, Neau, D.B, Mitchell, C.E, Bartlett, S.G, Newcomer, M.E. | 登録日 | 2013-11-26 | 公開日 | 2014-02-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | The structure of human 15-lipoxygenase-2 with a substrate mimic. J.Biol.Chem., 289, 2014
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3QUR
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![BU of 3qur by Molmil](/molmil-images/mine/3qur) | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgADP and fosfomycin monophosphate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FomA protein, MAGNESIUM ION, ... | 著者 | Pakhomova, S, Bartlett, S.G, Doerner, P.A, Newcomer, M.E. | 登録日 | 2011-02-24 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA. Biochemistry, 50, 2011
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3V92
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![BU of 3v92 by Molmil](/molmil-images/mine/3v92) | S663A Stable-5-LOX | 分子名称: | Arachidonate 5-lipoxygenase, FE (II) ION | 著者 | Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E. | 登録日 | 2011-12-23 | 公開日 | 2012-05-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. Faseb J., 26, 2012
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