5FB8
 
 | | Structure of Interleukin-16 bound to the 14.1 antibody | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Anti-IL-16 antibody 14.1 Fab domain Heavy Chain, ... | | 著者 | Hall, G, Cowan, R, Bayliss, R, Carr, M. | | 登録日 | 2015-12-14 | | 公開日 | 2016-06-08 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.
J.Biol.Chem., 291, 2016
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1E9T
 | | High resolution solution structure of human intestinal trefoil factor | | 分子名称: | INTESTINAL TREFOIL FACTOR | | 著者 | Lemercinier, X, Muskett, F, Cheeseman, B, McIntosh, P, Carr, M. | | 登録日 | 2000-10-26 | | 公開日 | 2000-12-08 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High-Resolution Solution Structure of Human Intestinal Trefoil Factor and Functional Insights from Detailed Structural Comparisons with the Other Members of the Trefoil Family of Mammalian Cell Motility Factors
Biochemistry, 40, 2001
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8CDG
 | | Crystal structure of human IL-17A cytokine in complex with macrocycle | | 分子名称: | (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid, Interleukin-17A | | 著者 | Schulze, M.-S. | | 登録日 | 2023-01-30 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.
Chem Sci, 14, 2023
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7NV1
 | | Human Pol Kappa holoenzyme with Ub-PCNA | | 分子名称: | DNA Primer, DNA Template, DNA polymerase kappa, ... | | 著者 | Lancey, C, De Biasio, A, Hamdan, S.M. | | 登録日 | 2021-03-15 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | | 主引用文献 | Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA.
Nat Commun, 12, 2021
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7NV0
 | | Human Pol Kappa holoenzyme with wt PCNA | | 分子名称: | DNA Primer, DNA Template, DNA polymerase kappa, ... | | 著者 | Lancey, C, De Biasio, A, Hamdan, S.M. | | 登録日 | 2021-03-15 | | 公開日 | 2021-11-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA.
Nat Commun, 12, 2021
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8AOK
 | | Complex of PD-L1 with VHH6 | | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Kang-Pettinger, T, Hall, G. | | 登録日 | 2022-08-08 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80.
J.Biol.Chem., 299, 2023
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8AOM
 | | Complex of PD-L1 with VHH1 | | 分子名称: | MAGNESIUM ION, Programmed cell death 1 ligand 1, VHH6 | | 著者 | Kang-Pettinger, T, Hall, G. | | 登録日 | 2022-08-08 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | | 主引用文献 | Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80.
J.Biol.Chem., 299, 2023
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4D6K
 | | Structure of DNTTIP1 dimerisation domain. | | 分子名称: | DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1 | | 著者 | Itoh, T, Fairall, L, Schwabe, J.W.R. | | 登録日 | 2014-11-11 | | 公開日 | 2015-02-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and Functional Characterization of a Cell Cycle Associated Hdac1/2 Complex Reveals the Structural Basis for Complex Assembly and Nucleosome Targeting.
Nucleic Acids Res., 43, 2015
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6Z2J
 | | The structure of the dimeric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | | 分子名称: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | | 登録日 | 2020-05-16 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.
Nat Commun, 11, 2020
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6Z2K
 | | The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | | 分子名称: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | | 登録日 | 2020-05-16 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.
Nat Commun, 11, 2020
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2KG7
 | | Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288 | | 分子名称: | ESAT-6-like protein esxH, Uncharacterized protein esxG (PE family protein) | | 著者 | Ilghari, D, Kirsty, L.L, Waters, L.C, Veverka, V.L, Philip, R.S, Carr, M.D. | | 登録日 | 2009-03-06 | | 公開日 | 2010-03-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the M. tuberculosis EsxG-EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes
J.Biol.Chem., 2011
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1NYO
 | | Solution structure of the antigenic TB protein MPT70/MPB70 | | 分子名称: | Immunogenic protein MPT70 | | 著者 | Bloemink, M.J, Dentten, E, Hewinson, R.G, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2003-02-13 | | 公開日 | 2003-08-19 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease
J.Biol.Chem., 278, 2003
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1LY7
 | | The solution structure of the the c-terminal domain of frataxin, the protein responsible for friedreich ataxia | | 分子名称: | frataxin | | 著者 | Musco, G, Stier, G, Kolmerer, B, Adinolfi, S, Martin, S, Frenkiel, T, Gibson, T, Pastore, A. | | 登録日 | 2002-06-07 | | 公開日 | 2002-06-26 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Towards a structural understanding of Friedreich's
ataxia: the solution structure of frataxin
Structure Fold.Des., 8, 2000
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