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3I5N
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BU of 3i5n by Molmil
Crystal structure of c-Met with triazolopyridazine inhibitor 13
分子名称: 7-methoxy-N-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-1,5-naphthyridin-4-amine, Hepatocyte growth factor receptor
著者Bellon, S.F, Whittington, D.A, Long, A.M, Boezio, A.A.
登録日2009-07-06
公開日2010-01-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
5ZDC
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BU of 5zdc by Molmil
Crystal structure of poly(ADP-ribose) glycohydrolase (PARG) from Deinococcus radiodurans in complex with ADP-ribose (P32)
分子名称: PHOSPHATE ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, poly ADP-ribose glycohydrolase
著者Cho, C.C, Hsu, C.H.
登録日2018-02-23
公開日2019-02-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.979 Å)
主引用文献Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans.
Nat Commun, 10, 2019
5ZDB
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BU of 5zdb by Molmil
Crystal structure of poly(ADP-ribose) glycohydrolase (PARG) from Deinococcus radiodurans in complex with ADP-ribose (P21)
分子名称: Poly ADP-ribose glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
著者Cho, C.C, Hsu, C.H.
登録日2018-02-23
公開日2019-02-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.972 Å)
主引用文献Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans.
Nat Commun, 10, 2019
6AP0
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BU of 6ap0 by Molmil
Crystal structure of human FLASH N-terminal domain C54S/C83A (Crystal form 2)
分子名称: CASP8-associated protein 2
著者Aik, W.S, Tong, L.
登録日2017-08-16
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.581 Å)
主引用文献The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing.
PLoS ONE, 12, 2017
5ZDG
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BU of 5zdg by Molmil
Crystal structure of poly(ADP-ribose) glycohydrolase (PARG) T267R mutant from Deinococcus radiodurans in complex with ADP-ribose
分子名称: Poly APD-ribose glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
著者Cho, C.C, Hsu, C.H.
登録日2018-02-23
公開日2019-02-27
最終更新日2020-03-11
実験手法X-RAY DIFFRACTION (2.594 Å)
主引用文献Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans.
Nat Commun, 10, 2019
5ZDE
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BU of 5zde by Molmil
Crystal structure of poly(ADP-ribose) glycohydrolase (PARG) from Deinococcus radiodurans in complex with ADP-ribose (P3221)
分子名称: Poly ADP-ribose glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
著者Cho, C.C, Hsu, C.H.
登録日2018-02-23
公開日2019-02-27
最終更新日2020-03-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans.
Nat Commun, 10, 2019
7Y0G
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BU of 7y0g by Molmil
Crystal structure of anti-mPEG h15-2b Fab
分子名称: 15-2b heavy chain, 15-2b light chain, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL
著者Chang, C.Y, Nguyen, T.M.T, Lin, E.C, Su, Y.C.
登録日2022-06-05
公開日2022-08-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group.
Commun Chem, 5, 2022
5ZDD
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BU of 5zdd by Molmil
Crystal structure of poly(ADP-ribose) glycohydrolase (PARG) from Deinococcus radiodurans in complex with ADP-ribose (P212121)
分子名称: PHOSPHATE ION, Poly ADP-ribose glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
著者Cho, C.C, Hsu, C.H.
登録日2018-02-23
公開日2019-02-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.725 Å)
主引用文献Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans.
Nat Commun, 10, 2019
5ZDF
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BU of 5zdf by Molmil
Crystal structure of poly(ADP-ribose) glycohydrolase (PARG) T267K mutant from Deinococcus radiodurans in complex with ADP-ribose
分子名称: Poly ADP-ribose glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
著者Cho, C.C, Hsu, C.H.
登録日2018-02-23
公開日2019-02-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.504 Å)
主引用文献Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans.
Nat Commun, 10, 2019
7X3N
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BU of 7x3n by Molmil
Crystal structure of anti-mPEG h15-2b Fab
分子名称: 15-2b-H, 15-2b-L, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL
著者Chang, C.Y, Nguyen, T.M.T, Toh, S.I, Su, Y.C.
登録日2022-03-01
公開日2023-03-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group
Commun Chem, 5, 2022
3O50
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BU of 3o50 by Molmil
Crystal structure of benzamide 9 bound to AuroraA
分子名称: N-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide, cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6
著者Huang, X.
登録日2010-07-27
公開日2010-08-18
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.
J.Med.Chem., 53, 2010
3O51
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BU of 3o51 by Molmil
Crystal structure of anthranilamide 10 bound to AuroraA
分子名称: N-[4-({3-[5-fluoro-2-(methylideneamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-2-(phenylamino)benzamide, cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6
著者Huang, X.
登録日2010-07-27
公開日2010-08-18
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.
J.Med.Chem., 53, 2010
4DEI
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BU of 4dei by Molmil
Crystal structure of c-Met in complex with triazolopyridinone inhibitor 24
分子名称: 3-{(1S)-1-[3-(2-methoxyethoxy)quinolin-6-yl]ethyl}-5-(3-methyl-1,2-thiazol-5-yl)-3,5-dihydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one, Hepatocyte growth factor receptor
著者Whittington, D.A, Long, A.M.
登録日2012-01-20
公開日2012-05-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4DEH
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BU of 4deh by Molmil
Crystal structure of c-Met in complex with triazolopyridinone inhibitor 3
分子名称: 5-phenyl-3-(quinolin-6-ylmethyl)-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one, Hepatocyte growth factor receptor
著者Whittington, D.A, Bellon, S.F, Long, A.M.
登録日2012-01-20
公開日2012-05-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4DEG
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BU of 4deg by Molmil
Crystal structure of c-Met in complex with triazolopyridazine inhibitor 2
分子名称: 7-methoxy-N-{[6-(3-methyl-1,2-thiazol-5-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}-1,5-naphthyridin-4-amine, Hepatocyte growth factor receptor
著者Whittington, D.A, Bellon, S.F, Long, A.M.
登録日2012-01-20
公開日2012-05-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
1ND4
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BU of 1nd4 by Molmil
Crystal structure of aminoglycoside-3'-phosphotransferase-IIa
分子名称: ACETATE ION, Aminoglycoside 3'-phosphotransferase, KANAMYCIN A, ...
著者Nurizzo, D, Shewry, S.C, Baker, E.N, Smith, C.A.
登録日2002-12-06
公開日2003-09-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance
J.Mol.Biol., 327, 2003
4I68
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BU of 4i68 by Molmil
Crystal structure of the R444A / R449A double mutant of the HERA RNA helicase RRM domain
分子名称: CHLORIDE ION, Heat resistant RNA dependent ATPase, ZINC ION
著者Rudolph, M.G, Klostermeier, D.
登録日2012-11-29
公開日2013-04-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera.
Nucleic Acids Res., 41, 2013
4I67
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BU of 4i67 by Molmil
Crystal structure of the RRM domain of RNA helicase HERA from T. thermophilus in complex with GGGC RNA
分子名称: 5'-R(P*GP*GP*GP*(RPC))-3', Heat resistant RNA dependent ATPase
著者Rudolph, M.G, Klostermeier, D.
登録日2012-11-29
公開日2013-04-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera.
Nucleic Acids Res., 41, 2013
4I69
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BU of 4i69 by Molmil
Crystal structure of the K463A mutant of the RRM domain of RNA helicase HERA from T. thermophilus
分子名称: CHLORIDE ION, Heat resistant RNA dependent ATPase
著者Rudolph, M.G, Klostermeier, D.
登録日2012-11-29
公開日2013-04-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera.
Nucleic Acids Res., 41, 2013
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