Crystal structure of c-Met in complex with triazolopyridazine inhibitor 2

Summary for 4DEG

Related4DEH 4DEI
DescriptorHepatocyte growth factor receptor, 7-methoxy-N-{[6-(3-methyl-1,2-thiazol-5-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}-1,5-naphthyridin-4-amine (3 entities in total)
Functional Keywordsproto-oncogene, receptor tyrosine kinase, rtk, atp-binding, hepatocyte growth factor/scatter factor, hgf/sf, phosphoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein. Isoform 3: Secreted P08581
Total number of polymer chains1
Total molecular weight35620.16
Whittington, D.A.,Bellon, S.F.,Long, A.M. (deposition date: 2012-01-20, release date: 2012-05-30, Last modification date: 2012-06-20)
Primary citation
Bode, C.M.,Boezio, A.A.,Albrecht, B.K.,Bellon, S.F.,Berry, L.,Broome, M.A.,Choquette, D.,Dussault, I.,Lewis, R.T.,Lin, M.H.,Rex, K.,Whittington, D.A.,Yang, Y.,Harmange, J.C.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22:4089-4093, 2012
PubMed: 22595176 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2012.04.072
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.247200.8%11.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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