4DEG
Crystal structure of c-Met in complex with triazolopyridazine inhibitor 2
Summary for 4DEG
Entry DOI | 10.2210/pdb4deg/pdb |
Related | 4DEH 4DEI |
Descriptor | Hepatocyte growth factor receptor, 7-methoxy-N-{[6-(3-methyl-1,2-thiazol-5-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}-1,5-naphthyridin-4-amine (3 entities in total) |
Functional Keywords | proto-oncogene, receptor tyrosine kinase, rtk, atp-binding, hepatocyte growth factor/scatter factor, hgf/sf, phosphoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 35620.16 |
Authors | Whittington, D.A.,Bellon, S.F.,Long, A.M. (deposition date: 2012-01-20, release date: 2012-05-30, Last modification date: 2024-02-28) |
Primary citation | Bode, C.M.,Boezio, A.A.,Albrecht, B.K.,Bellon, S.F.,Berry, L.,Broome, M.A.,Choquette, D.,Dussault, I.,Lewis, R.T.,Lin, M.H.,Rex, K.,Whittington, D.A.,Yang, Y.,Harmange, J.C. Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors. Bioorg.Med.Chem.Lett., 22:4089-4093, 2012 Cited by PubMed: 22595176DOI: 10.1016/j.bmcl.2012.04.072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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