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4DEH

Crystal structure of c-Met in complex with triazolopyridinone inhibitor 3

Summary for 4DEH
Entry DOI10.2210/pdb4deh/pdb
Related4DEI 4DEg
DescriptorHepatocyte growth factor receptor, 5-phenyl-3-(quinolin-6-ylmethyl)-3,5,6,7-tetrahydro-4H-[1,2,3]triazolo[4,5-c]pyridin-4-one (3 entities in total)
Functional Keywordsproto-oncogene, receptor tyrosine kinase, rtk, atp-binding, hepatocyte growth factor/scatter factor, hgf/sf, phosphoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains1
Total formula weight35571.11
Authors
Whittington, D.A.,Bellon, S.F.,Long, A.M. (deposition date: 2012-01-20, release date: 2012-05-30, Last modification date: 2024-02-28)
Primary citationBode, C.M.,Boezio, A.A.,Albrecht, B.K.,Bellon, S.F.,Berry, L.,Broome, M.A.,Choquette, D.,Dussault, I.,Lewis, R.T.,Lin, M.H.,Rex, K.,Whittington, D.A.,Yang, Y.,Harmange, J.C.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg.Med.Chem.Lett., 22:4089-4093, 2012
Cited by
PubMed: 22595176
DOI: 10.1016/j.bmcl.2012.04.072
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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