6QXB
 
 | | NMR structure of peptide 7, characterized by a cis-4-amino-Pro residue, with a significant lower MIC on E. coli | | 分子名称: | PHE-VAL-CAP-TRP-PHE-SER-LYS-PHE-LEU-GLY-ARG-ILE-LEU-NH2 | | 著者 | Brancaccio, D, Carotenuto, A, Merlino, F, Grieco, P, Novellino, E. | | 登録日 | 2019-03-07 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-11-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L.
Chemmedchem, 14, 2019
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6QXC
 | | NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa. | | 分子名称: | PHE-VAL-TCP-TRP-PHE-SER-LYS-PHE-LEU-GLY-ARG-ILE-LEU-NH2 | | 著者 | Brancaccio, D, Carotenuto, A, Merlino, F, Grieco, P, Novellino, E. | | 登録日 | 2019-03-07 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-11-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L.
Chemmedchem, 14, 2019
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6FOE
 | | BaxB01 Fab fragment | | 分子名称: | Fab BaxB01 heavy chain, Fab BaxB01 light chain | | 著者 | Hollerweger, J, Schinagl, A, Kerschbaumer, R.J, Scheiflinger, F, Thiele, M, Goettig, P, Brandstetter, H. | | 登録日 | 2018-02-07 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Role of the Cysteine 81 Residue of Macrophage Migration Inhibitory Factor as a Molecular Redox Switch.
Biochemistry, 57, 2018
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3H4V
 | | Selective screening and design to identify inhibitors of leishmania major pteridine reductase 1 | | 分子名称: | METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1 | | 著者 | Mcluskey, K, Gibellini, F, Hunter, W.N. | | 登録日 | 2009-04-21 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
Proc.Natl.Acad.Sci.USA, 105, 2008
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6S4A
 | | Structure of human MTHFD2 in complex with TH9028 | | 分子名称: | (2~{S})-2-[[5-[[2,4-bis(azanyl)-6-oxidanylidene-5~{H}-pyrimidin-5-yl]carbamoylamino]pyridin-2-yl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... | | 著者 | Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | | 登録日 | 2019-06-27 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer, 3, 2022
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6S4F
 | | Structure of human MTHFD2 in complex with TH9619 | | 分子名称: | (E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid, ADENOSINE-5'-DIPHOSPHATE, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... | | 著者 | Scaletti, E.R, Gustafsson, R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | | 登録日 | 2019-06-27 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer, 3, 2022
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6S4E
 | | Structure of human MTHFD2 in complex with TH7299 | | 分子名称: | (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | | 著者 | Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | | 登録日 | 2019-06-27 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer, 3, 2022
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8AS8
 | | E. coli Wadjet JetABC monomer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, JetA, JetB, ... | | 著者 | Roisne-Hamelin, F, Beckert, B, Li, Y, Myasnikov, A, Gruber, S. | | 登録日 | 2022-08-18 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage.
Mol.Cell, 82, 2022
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8BFN
 | | E. coli Wadjet JetABC dimer of dimers | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, JetA, JetB, ... | | 著者 | Roisne-Hamelin, F, Beckert, B, Myasnikov, A, Li, Y, Gruber, S. | | 登録日 | 2022-10-26 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage.
Mol.Cell, 82, 2022
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1UG3
 | | C-terminal portion of human eIF4GI | | 分子名称: | eukaryotic protein synthesis initiation factor 4G | | 著者 | Bellsolell, L, Cho-Park, P.F, Poulin, F, Sonenberg, N, Burley, S.K. | | 登録日 | 2003-06-11 | | 公開日 | 2005-03-22 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1
Structure, 14, 2006
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1MJ1
 | | FITTING THE TERNARY COMPLEX OF EF-Tu/tRNA/GTP AND RIBOSOMAL PROTEINS INTO A 13 A CRYO-EM MAP OF THE COLI 70S RIBOSOME | | 分子名称: | Elongation Factor Tu, L11 ribosomal protein, Phe-tRNA, ... | | 著者 | Stark, H, Rodnina, M.V, Wieden, H.-J, Zemlin, F, Wintermeyer, W, Vanheel, M. | | 登録日 | 2002-08-26 | | 公開日 | 2002-11-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (13 Å) | | 主引用文献 | Ribosome Interactions of Aminoacyl-tRNA and Elongation Factor TU in the
Codon Recognition Complex
Nat.Struct.Biol., 9, 2002
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8S8P
 | | Restriction on Ku Inward Translocation Caps Telomere Ends | | 分子名称: | ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit 2, DNA (5'-D(*AP*CP*AP*CP*AP*CP*AP*CP*AP*CP*CP*CP*AP*CP*AP*CP*AP*CP*CP*AP*C)-3'), ... | | 著者 | Mattarocci, S, Baconnais, S, Roisne-Hamelin, F, Pobiega, S, Alibert, O, Morin, V, Deshayes, A, Veaute, X, Ropars, V, Mazon, G, Busso, D, Fernandez Varela, P, Le Cam, E, Charbonnier, J, Cuniasse, P, Marcand, S. | | 登録日 | 2024-03-07 | | 公開日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | A Restriction on Ku Inward Translocation Caps Telomere Ends
To Be Published
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8S82
 | | Restriction on Ku Inward Translocation Caps Telomere Ends | | 分子名称: | ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit 2, DNA (5'-D(*AP*CP*AP*CP*AP*CP*AP*CP*AP*CP*CP*CP*AP*CP*AP*CP*AP*CP*CP*AP*C)-3'), ... | | 著者 | Mattarocci, S, Baconnais, S, Roisne-Hamelin, F, Pobiega, S, Alibert, O, Morin, V, Deshayes, A, Veaute, X, Ropars, V, Mazon, G, Busso, D, Fernandez Varela, P, Le Cam, E, Charbonnier, J, Cuniasse, P, Marcand, S. | | 登録日 | 2024-03-05 | | 公開日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | A Restriction on Ku Inward Translocation Caps Telomere Ends
To Be Published
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2AWH
 | | Human Nuclear Receptor-Ligand Complex 1 | | 分子名称: | Peroxisome proliferator activated receptor delta, VACCENIC ACID, heptyl beta-D-glucopyranoside | | 著者 | Fyffe, S.A, Alphey, M.S, Buetow, L, Smith, T.K, Ferguson, M.A.J, Sorensen, M.D, Bjorkling, F, Hunter, W.N. | | 登録日 | 2005-09-01 | | 公開日 | 2006-02-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids
J.Mol.Biol., 356, 2006
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7UCX
 | | LRP8 11H1 Fab complexed to a cyclized CR1 peptide | | 分子名称: | 11H1 Fab Heavy chain, 11H1 Fab Light chain, Cyclized CR1 peptide, ... | | 著者 | Argiriadi, M.A, Deng, K, Egan, D, Gao, L, Gizatullin, F, Harlan, J, Karaoglu, D, Qiu, W, Goodearl, A. | | 登録日 | 2022-03-17 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | The use of cyclic peptide antigens to generate LRP8 specific antibodies
Front Drug Discov (Lausanne), 2, 2023
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2XVL
 | | crystal structure of alpha-xylosidase (GH31) from Cellvibrio japonicus in complex with Pentaerythritol propoxylate (5 4 PO OH) | | 分子名称: | (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, ALPHA-XYLOSIDASE, PUTATIVE, ... | | 著者 | Larsbrink, J, Izumi, A, Ibatullin, F, Nakhai, A, Gilbert, H.J, Davies, G.J, Brumer, H. | | 登録日 | 2010-10-26 | | 公開日 | 2011-04-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural and Enzymatic Characterisation of a Glycoside Hydrolase Family 31 Alpha-Xylosidase from Cellvibrio Japonicus Involved in Xyloglucan Saccharification.
Biochem.J., 436, 2011
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2XVG
 | | crystal structure of alpha-xylosidase (GH31) from Cellvibrio japonicus | | 分子名称: | 1,2-ETHANEDIOL, ALPHA XYLOSIDASE, CHLORIDE ION, ... | | 著者 | Larsbrink, J, Izumi, A, Ibatullin, F, Nakhai, A, Gilbert, H.J, Davies, G.J, Brumer, H. | | 登録日 | 2010-10-26 | | 公開日 | 2011-04-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and Enzymatic Characterisation of a Glycoside Hydrolase Family 31 Alpha-Xylosidase from Cellvibrio Japonicus Involved in Xyloglucan Saccharification.
Biochem.J., 436, 2011
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2XVK
 | | crystal structure of alpha-xylosidase (GH31) from Cellvibrio japonicus in complex with 5-fluoro-alpha-D-xylopyranosyl fluoride | | 分子名称: | (2R,3S,5R,6S)-2,6-DIFLUOROOXANE-3,4,5-TRIOL, ALPHA-XYLOSIDASE, PUTATIVE, ... | | 著者 | Larsbrink, J, Izumi, A, Ibatullin, F, Nakhai, A, Gilbert, H.J, Davies, G.J, Brumer, H. | | 登録日 | 2010-10-26 | | 公開日 | 2011-04-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | Structural and Enzymatic Characterisation of a Glycoside Hydrolase Family 31 Alpha-Xylosidase from Cellvibrio Japonicus Involved in Xyloglucan Saccharification.
Biochem.J., 436, 2011
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1BRD
 | | Model for the structure of Bacteriorhodopsin based on high-resolution Electron Cryo-microscopy | | 分子名称: | BACTERIORHODOPSIN PRECURSOR, RETINAL | | 著者 | Henderson, R, Baldwin, J.M, Ceska, T.A, Zemlin, F, Beckmann, E, Downing, K.H. | | 登録日 | 1990-05-23 | | 公開日 | 1991-04-15 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (3.5 Å) | | 主引用文献 | Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.
J.Mol.Biol., 213, 1990
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3RPL
 | | D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase of Synechocystis sp. PCC 6803 in complex with FRUCTOSE-1,6-BISPHOSPHATE | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... | | 著者 | Hu, X, Hui, D, Lingling, F, Jian, W. | | 登録日 | 2011-04-26 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | New insights into the structural and interactional basis for a promising route towards fructose-1,6-/sedoheptulose-1,7-bisphosphatases controlling
To be Published
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3ROJ
 | | D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase of Synechocystis sp. PCC 6803 | | 分子名称: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase, ... | | 著者 | Hu, X, Hui, D, Lingling, F, Jian, W. | | 登録日 | 2011-04-26 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | New insights into the structural and interactional basis for a promising route towards fructose-1,6-/sedoheptulose-1,7-bisphosphatases controlling
To be Published
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8S7O
 | | M. tuberculosis gyrase holocomplex with 150 bp DNA and BDM71403 | | 分子名称: | 6-[[2-[1-(6-methoxy-1,5-naphthyridin-4-yl)-1,2,3-triazol-4-yl]ethylamino]methyl]-4H-1,4-benzothiazin-3-one, DNA (5'-D(*CP*CP*GP*GP*AP*AP*GP*GP*GP*GP*TP*AP*AP*TP*AP*CP*T)-3'), DNA gyrase subunit A, ... | | 著者 | Gedeon, A, Yab, E, Dinut, A, Sadowski, E, Capton, E, Dreneau, A, Gioia, B, Piveteau, C, Djaout, K, Lecat, E, Wehenkel, A.M, Gubellini, F, Mechaly, A, Alzari, P.M, Deprez, B, Baulard, A, Aubry, A, Willand, N, Petrella, S. | | 登録日 | 2024-03-04 | | 公開日 | 2025-03-19 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | M. tuberculosis gyrase holocomplex with 150 bp DNA and BDM71403
To Be Published
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2VWL
 | | Aminopyrrolidine Factor Xa inhibitor | | 分子名称: | 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3R,5S)-1-{[2-FLUORO-4-(2-OXO-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-5-HYDROXYMETHYL-PYRROLIDIN-3-YL)-AMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | | 著者 | Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W. | | 登録日 | 2008-06-26 | | 公開日 | 2009-07-07 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
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2VVV
 | | Aminopyrrolidine-related triazole Factor Xa inhibitor | | 分子名称: | 5-chloro-N-[1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)-1H-1,2,4-triazol-3-yl]thiophene-2-carboxamide, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | | 著者 | Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W. | | 登録日 | 2008-06-12 | | 公開日 | 2009-07-07 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
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2VWO
 | | Aminopyrrolidine Factor Xa inhibitor | | 分子名称: | 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | | 著者 | Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W. | | 登録日 | 2008-06-26 | | 公開日 | 2009-07-07 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
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