3DSS
 
 | | Crystal structure of RabGGTase(DELTA LRR; DELTA IG) | | 分子名称: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | | 著者 | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | | 登録日 | 2008-07-14 | | 公開日 | 2008-09-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J., 27, 2008
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3DSX
 | | Crystal structure of RabGGTase(DELTA LRR; DELTA IG)in complex with di-prenylated peptide Ser-Cys(GG)-Ser-Cys(GG) derivated from Rab7 | | 分子名称: | CALCIUM ION, GERAN-8-YL GERAN, Geranylgeranyl transferase type-2 subunit alpha, ... | | 著者 | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | | 登録日 | 2008-07-14 | | 公開日 | 2008-09-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J., 27, 2008
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3EUV
 | | Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10, W102T, Y154T) in complex with BiotinGPP | | 分子名称: | (2E,6E)-3,7-dimethyl-8-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octa-2,6-dien-1-yl trihydrogen diphosphate, Protein farnesyltransferase subunit beta, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, ... | | 著者 | Guo, Z, Nguyen, U.T.T, Delon, C, Bon, R.S, Blankenfeldt, W, Goody, R.S, Waldmann, H, Wolters, D, Alexandrov, K. | | 登録日 | 2008-10-11 | | 公開日 | 2009-07-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Analysis of the eukaryotic prenylome by isoprenoid affinity tagging
Nat.Chem.Biol., 5, 2009
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3EU5
 | | Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BiotinGPP | | 分子名称: | (2E,6E)-3,7-dimethyl-8-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octa-2,6-dien-1-yl trihydrogen diphosphate, Protein farnesyltransferase subunit beta, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, ... | | 著者 | Guo, Z, Nguyen, U.T.T, Delon, C, Bon, R.S, Blankenfeldt, W, Goody, R.S, Waldmann, H, Wolters, D, Alexandrov, K. | | 登録日 | 2008-10-09 | | 公開日 | 2009-07-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Analysis of the eukaryotic prenylome by isoprenoid affinity tagging
Nat.Chem.Biol., 5, 2009
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1FKM
 | | CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P | | 分子名称: | PROTEIN (GYP1P) | | 著者 | Rak, A, Fedorov, R, Alexandrov, K, Albert, S, Goody, R.S, Gallwitz, D, Scheidig, A.J. | | 登録日 | 2000-08-09 | | 公開日 | 2001-02-09 | | 最終更新日 | 2022-12-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.
EMBO J., 19, 2000
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1UKV
 | | Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase | | 分子名称: | GERAN-8-YL GERAN, GTP-binding protein YPT1, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Rak, A, Pylypenko, O, Durek, T, Watzke, A, Kushnir, S, Brunsveld, L, Waldmann, H, Goody, R.S, Alexandrov, K. | | 登録日 | 2003-09-01 | | 公開日 | 2004-09-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
Science, 302, 2003
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8G0M
 | | Structure of complex between TV6.6 and CD98hc ECD | | 分子名称: | 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, TETRAETHYLENE GLYCOL, ... | | 著者 | Kariolis, M.S, Lexa, K, Liau, N.P.D, Srivastava, D, Tran, H, Wells, R.C. | | 登録日 | 2023-01-31 | | 公開日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | CD98hc is a target for brain delivery of biotherapeutics.
Nat Commun, 14, 2023
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8DEG
 | | Crystal structure of DLK in complex with inhibitor DN0011197 | | 分子名称: | Mitogen-activated protein kinase kinase kinase 12, methyl (1S,4S)-5-{(4P)-4-[5-amino-6-(difluoromethoxy)pyrazin-2-yl]-6-[(1R,4R)-2-azabicyclo[2.1.1]hexan-2-yl]pyridin-2-yl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate | | 著者 | Srivastava, A, Lexa, K, de Vicente, J. | | 登録日 | 2022-06-20 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J.Med.Chem., 65, 2022
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4WVF
 | | Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1 | | 分子名称: | (2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Sun, Q, Chook, Y. | | 登録日 | 2014-11-05 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nat.Neurosci., 18, 2015
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2GIL
 | | Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-6A | | 著者 | Bergbrede, T, Pylypenko, O, Rak, A, Alexandrov, K. | | 登録日 | 2006-03-29 | | 公開日 | 2006-06-27 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution
J.STRUCT.BIOL., 152, 2005
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3KH3
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3KH4
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2FU5
 | | structure of Rab8 in complex with MSS4 | | 分子名称: | BETA-MERCAPTOETHANOL, Guanine nucleotide exchange factor MSS4, Ras-related protein Rab-8A, ... | | 著者 | Itzen, A, Pylypenko, O, Goody, R.S, Rak, A. | | 登録日 | 2006-01-26 | | 公開日 | 2006-04-04 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Nucleotide exchange via local protein unfolding-structure of Rab8 in complex with MSS4
Embo J., 25, 2006
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1KY2
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1KY3
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4QKV
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4QKW
 | | Crystal structure of the zebrafish cavin4a HR1 domain | | 分子名称: | CHLORIDE ION, Muscle-related coiled-coil protein | | 著者 | Kovtun, O, Tillu, V, Parton, R.G, Collins, B.M. | | 登録日 | 2014-06-10 | | 公開日 | 2015-03-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural insights into the organization of the cavin membrane coat complex
Dev.Cell, 31, 2014
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1EK0
 | | GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICKEL (II) ION, ... | | 著者 | Esters, H, Scheidig, A.J. | | 登録日 | 2000-03-06 | | 公開日 | 2000-04-17 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis.
J.Mol.Biol., 298, 2000
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