4HHJ
| Dengue serotype 3 RNA-dependent RNA polymerase | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Non-structural protein 5, ... | 著者 | Noble, C.G, Lescar, J. | 登録日 | 2012-10-10 | 公開日 | 2013-02-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor J.Virol., 87, 2013
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5AAM
| Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency | 分子名称: | ENVELOPE PROTEIN, SCFV513 | 著者 | Wong, Y.H, Robinson, L.N, Lescar, J, Sasisekharan, R. | 登録日 | 2015-07-27 | 公開日 | 2015-08-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Structure-Guided Design of an Anti-Dengue Antibody Directed to a Non-Immunodominant Epitope. Cell(Cambridge,Mass.), 162, 2015
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5AAW
| Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency | 分子名称: | DENGUE SEROTYPE 4 ENVELOPE PROTEIN DOMAIN 3, SCFV513 | 著者 | Wong, Y, Robinson, L, Lescar, J, Sasisekharan, R. | 登録日 | 2015-07-30 | 公開日 | 2015-09-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.27 Å) | 主引用文献 | Structure-Guided Design of an Anti-Dengue Antibody Directed to a Non-Immunodominant Epitope. Cell(Cambridge,Mass.), 162, 2015
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6U5O
| Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer | 分子名称: | Phosphoprotein, RNA-directed RNA polymerase L | 著者 | Pan, J, Qian, X, Lattmann, S, Sahili, A.E, Yeo, T.H, Kalocsay, M, Fearns, R, Lescar, J. | 登録日 | 2019-08-28 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of the human metapneumovirus polymerase phosphoprotein complex. Nature, 577, 2020
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1SVZ
| Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease | 分子名称: | epitope peptide corresponding to N-terminus of HIV-2 protease, single-chain Fv fragment 1696 | 著者 | Rezacova, P, Brynda, J, Lescar, J, Bentley, G.A, Fabry, M, Horejsi, M, Sedlacek, J. | 登録日 | 2004-03-30 | 公開日 | 2005-03-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide J.Struct.Biol., 149, 2005
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6XD1
| Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-640 | 分子名称: | (2R)-4-(butyl{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}carbamoyl)-1-(2,2-diphenylpropanoyl)piperazine-2-carboxylic acid, RNA-dependent RNA polymerase, ZINC ION | 著者 | Arora, R, Benson, T.E, Liew, C.W, Lescar, J. | 登録日 | 2020-06-09 | 公開日 | 2020-09-23 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.954 Å) | 主引用文献 | Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies. J.Virol., 94, 2020
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6XD0
| Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-434 | 分子名称: | 2-[({2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)amino]-2,3-dihydro-1H-indene-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Arora, R, Benson, T.E, Liew, C.W, Lescar, J. | 登録日 | 2020-06-09 | 公開日 | 2020-09-23 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.012 Å) | 主引用文献 | Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies. J.Virol., 94, 2020
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4S2Q
| Crystal Structure of HMG domain of the chondrogenesis master regulator, Sox9 in complex with ChIP-Seq identified DNA element | 分子名称: | DNA (5'-D(P*AP*GP*GP*AP*GP*AP*AP*CP*AP*AP*AP*GP*CP*CP*TP*G)-3'), DNA (5'-D(P*AP*GP*GP*CP*TP*TP*TP*GP*TP*TP*CP*TP*CP*CP*TP*G)-3'), Transcription factor SOX-9 | 著者 | Vivekanandan, S, Moovarkumudalvan, B, Lescar, J, Kolatkar, P.R. | 登録日 | 2015-01-21 | 公開日 | 2016-02-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal Structure of HMG domain of the chondrogenesis master regulator, Sox9 in complex with ChIP-Seq identified DNA element To be Published
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7WPV
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7WPH
| SARS-CoV2 RBD bound to Fab06 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB06 light chain, Fab06 heavy chain, ... | 著者 | Lin, J.Q, El Sahili, A, Lescar, J. | 登録日 | 2022-01-23 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth. Nat Commun, 13, 2022
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3SY8
| Crystal structure of the response regulator RocR | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, RocR | 著者 | Chen, M.W, Kotaka, M, Vonrhein, C, Bricogne, G, Lescar, J. | 登録日 | 2011-07-16 | 公開日 | 2012-07-18 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling. J.Bacteriol., 194, 2012
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4URG
| Crystal Structure of GGDEF domain from T.maritima (active-like dimer) | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DIGUANYLATE CYCLASE | 著者 | Deepthi, A, Liew, C.W, Liang, Z.X, Swaminathan, K, Lescar, J. | 登録日 | 2014-06-30 | 公開日 | 2014-10-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of a Diguanylate Cyclase from Thermotoga Maritima: Insights Into Activation, Feedback Inhibition and Thermostability Plos One, 9, 2014
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4URQ
| Crystal Structure of GGDEF domain (I site mutant) from T.maritima | 分子名称: | DIGUANYLATE CYCLASE | 著者 | Deepthi, A, Liew, C.W, Liang, Z.X, Swamianthan, K, Lescar, J. | 登録日 | 2014-07-01 | 公開日 | 2014-10-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of a Diguanylate Cyclase from Thermotoga Maritima: Insights Into Activation, Feedback Inhibition and Thermostability Plos One, 9, 2014
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4URS
| Crystal Structure of GGDEF domain from T.maritima | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DIGUANYLATE CYCLASE, ... | 著者 | Deepthi, A, Liew, C.W, Liang, Z.X, Swaminathan, K, Lescar, J. | 登録日 | 2014-07-02 | 公開日 | 2014-10-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Structure of a Diguanylate Cyclase from Thermotoga Maritima: Insights Into Activation, Feedback Inhibition and Thermostability Plos One, 9, 2014
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7XXL
| RBD in complex with Fab14 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab14 heavy chain, Fab14 light chain, ... | 著者 | Lin, J.Q, Tan, Y.J.E, Wu, B, Lescar, J. | 登録日 | 2022-05-30 | 公開日 | 2022-09-14 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | 主引用文献 | Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth. Nat Commun, 13, 2022
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2XEM
| Induced-fit and allosteric effects upon polyene binding revealed by crystal structures of the Dynemicin thioesterase | 分子名称: | (3E,5E,7E,9E,11E,13E)-pentadeca-3,5,7,9,11,13-hexaen-2-one, DYNE7 | 著者 | Liew, C.W, Sharff, A, Kotaka, M, Kong, R, Bricogne, G, Liang, Z.X, Lescar, J. | 登録日 | 2010-05-17 | 公開日 | 2010-10-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Induced-Fit Upon Ligand Binding Revealed by Crystal Structures of the Hot-Dog Fold Thioesterase in Dynemicin Biosynthesis. J.Mol.Biol., 404, 2010
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2XFL
| Induced-fit and allosteric effects upon polyene binding revealed by crystal structures of the Dynemicin thioesterase | 分子名称: | DYNE7 | 著者 | Liew, C.W, Sharff, A, Kotaka, M, Kong, R, Sun, H, Bricogne, G, Liang, Z, Lescar, J. | 登録日 | 2010-05-26 | 公開日 | 2010-10-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Induced-Fit Upon Ligand Binding Revealed by Crystal Structures of the Hot-Dog Fold Thioesterase in Dynemicin Biosynthesis. J.Mol.Biol., 404, 2010
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6L4V
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6L4W
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6LD2
| Zika NS5 polymerase domain | 分子名称: | (1S,2S,4S,5R)-2,4-dimethoxy-5-thiophen-2-yl-cyclohexane-1-carboxylic acid, RNA-directed RNA polymerase NS5, ZINC ION | 著者 | El Sahili, A, Lescar, J. | 登録日 | 2019-11-20 | 公開日 | 2020-08-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6LD1
| Zika NS5 polymerase domain | 分子名称: | 1,2-ETHANEDIOL, RNA-directed RNA polymerase NS5, ZINC ION | 著者 | El Sahili, A, Lescar, J. | 登録日 | 2019-11-20 | 公開日 | 2020-08-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6L4Y
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6LD5
| Zika NS5 polymerase domain | 分子名称: | 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... | 著者 | El Sahili, A, Lescar, J. | 登録日 | 2019-11-20 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6L4X
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6LD4
| Zika NS5 polymerase domain | 分子名称: | 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, 3-methoxybenzenesulfonamide, RNA-directed RNA polymerase NS5, ... | 著者 | El Sahili, A, Lescar, J. | 登録日 | 2019-11-20 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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