5AAW

Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency

Replaces:  4UDZ

Summary for 5AAW

Related5AAM
DescriptorSCFV513, DENGUE SEROTYPE 4 ENVELOPE PROTEIN DOMAIN 3 (3 entities in total)
Functional Keywordsviral protein, scfv dengue antibody envelope domain iii
Biological sourceMUS MUSCULUS (HOUSE MOUSE)
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Total number of polymer chains12
Total molecular weight240720.29
Authors
Wong, Y.,Robinson, L.,Lescar, J.,Sasisekharan, R. (deposition date: 2015-07-30, release date: 2015-09-30, Last modification date: 2016-04-06)
Primary citation
Robinson, L.N.,Tharakaraman, K.,Rowley, K.J.,Costa, V.V.,Chan, K.R.,Wong, Y.H.,Ong, L.C.,Tan, H.C.,Koch, T.,Cain, D.,Kirloskar, R.,Viswanathan, K.,Liew, C.W.,Tissire, H.,Ramakrishnan, B.,Myette, J.R.,Babcock, G.J.,Sasisekharan, V.,Alonso, S.,Chen, J.,Lescar, J.,Shriver, Z.,Ooi, E.E.,Sasisekharan, R.
Structure-Guided Design of an Anti-Dengue Antibody Directed to a Non-Immunodominant Epitope.
Cell(Cambridge,Mass.), 162:493-, 2015
PubMed: 26189681 (PDB entries with the same primary citation)
DOI: 10.1016/J.CELL.2015.06.057
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.27 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25950.1%13.1%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report