7QO9
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![BU of 7qo9 by Molmil](/molmil-images/mine/7qo9) | SARS-CoV-2 S Omicron Spike B.1.1.529 - RBD and NTD (Local) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,SARS-CoV-2 S Omicron Spike B.1.1.529, ... | 著者 | Ni, D, Lau, K, Turelli, P, Beckert, B, Nazarov, S, Pojer, F, Myasnikov, A, Stahlberg, H, Trono, D. | 登録日 | 2021-12-23 | 公開日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion Biorxiv, 2021
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7QTI
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![BU of 7qti by Molmil](/molmil-images/mine/7qti) | SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P2G3 Heavy Chain, ... | 著者 | Ni, D, Lau, K, Turelli, P, Fenwick, C, Perez, L, Pojer, F, Stahlberg, H, Pantaleo, G, Trono, D. | 登録日 | 2022-01-14 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys. Nat Microbiol, 7, 2022
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7QTJ
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![BU of 7qtj by Molmil](/molmil-images/mine/7qtj) | SARS-CoV-2 S Omicron Spike B.1.1.529 - RBD up - 1-P2G3 and 1-P5C3 Fabs (Local) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P2G3 Heavy Chain, P2G3 Light Chain, ... | 著者 | Ni, D, Lau, K, Turelli, P, Fenwick, C, Perez, L, Pojer, F, Stahlberg, H, Pantaleo, G, Trono, D. | 登録日 | 2022-01-14 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (4.01 Å) | 主引用文献 | Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys. Nat Microbiol, 7, 2022
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7QUV
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![BU of 7quv by Molmil](/molmil-images/mine/7quv) | Crystal structure of human Calprotectin (S100A8/S100A9) in complex with Peptide 3 | 分子名称: | 1,2-ETHANEDIOL, 4-methanoyl-2-(6-oxidanyl-3-oxidanylidene-4~{H}-xanthen-9-yl)benzoic acid, AMINO GROUP, ... | 著者 | Diaz-Perlas, C, Heinis, C, Pojer, F, Lau, K. | 登録日 | 2022-01-19 | 公開日 | 2023-02-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays. Nat Commun, 14, 2023
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7QTK
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![BU of 7qtk by Molmil](/molmil-images/mine/7qtk) | SARS-CoV-2 S Omicron Spike B.1.1.529 - RBD down - 1-P2G3 Fab (Local) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P2G3 Heavy Chain, P2G3 Light Chain, ... | 著者 | Ni, D, Lau, K, Turelli, P, Fenwick, C, Perez, L, Pojer, F, Stahlberg, H, Pantaleo, G, Trono, D. | 登録日 | 2022-01-14 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | 主引用文献 | Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys. Nat Microbiol, 7, 2022
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7ZAK
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![BU of 7zak by Molmil](/molmil-images/mine/7zak) | Crystal structure of HLA-DP (DPA1*02:01-DPB1*01:01) in complex with a peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, MAGNESIUM ION, ... | 著者 | Racle, J, Guillaume, P, Larabi, A, Lau, K, Pojer, F, Gfeller, D. | 登録日 | 2022-03-22 | 公開日 | 2023-03-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes. Immunity, 56, 2023
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7ZFR
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![BU of 7zfr by Molmil](/molmil-images/mine/7zfr) | Crystal structure of HLA-DP (DPA1*02:01-DPB1*01:01) in complex with a peptide bound in the reverse direction | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DP alpha chain (DPA1*02:01), MHC class II HLA-DP beta chain (DPB1*01:01), ... | 著者 | Racle, J, Guillaume, P, Larabi, A, Lau, K, Pojer, F, Gfeller, D. | 登録日 | 2022-04-01 | 公開日 | 2023-04-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes. Immunity, 56, 2023
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3S44
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![BU of 3s44 by Molmil](/molmil-images/mine/3s44) | Crystal Structure of Pasteurella multocida sialyltransferase M144D mutant with CMP bound | 分子名称: | Alpha-2,3/2,6-sialyltransferase/sialidase, CMP-3F(a)-Neu5Ac | 著者 | Sugiarto, G, Lau, K, Li, Y, Lim, S, Ames, J.B, Le, D.-T, Fisher, A.J, Chen, X. | 登録日 | 2011-05-18 | 公開日 | 2012-08-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | A Sialyltransferase Mutant with Decreased Donor Hydrolysis and Reduced Sialidase Activities for Directly Sialylating Lewis(x). Acs Chem.Biol., 7, 2012
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6TLC
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![BU of 6tlc by Molmil](/molmil-images/mine/6tlc) | Unphosphorylated human STAT3 in complex with MS3-6 monobody | 分子名称: | Monobody, Signal transducer and activator of transcription 3 | 著者 | La Sala, G, Lau, K, Reynaud, A, Pojer, F, Hantschel, O. | 登録日 | 2019-12-02 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains. Nat Commun, 11, 2020
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7ZN1
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![BU of 7zn1 by Molmil](/molmil-images/mine/7zn1) | Avidin + Biotin-Tempo | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-[(3~{a}~{S},4~{S},6~{a}~{R})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]-~{N}-(2,2,6,6-tetramethyl-1-oxidanyl-piperidin-4-yl)hexanamide, ... | 著者 | Milani, J, Lau, K, Pojer, F, Ansermet, J.P, Saenz, F. | 登録日 | 2022-04-20 | 公開日 | 2023-05-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Avidin + Biotin-Tempo To Be Published
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8PQ2
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![BU of 8pq2 by Molmil](/molmil-images/mine/8pq2) | XBB 1.0 RBD bound to P4J15 (Local) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, P4J15 Fragment Antigen-Binding Heavy Chain, P4J15 Fragment Antigen-Binding Light Chain, ... | 著者 | Duhoo, Y, Lau, K. | 登録日 | 2023-07-10 | 公開日 | 2023-11-01 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys. J Infect, 87, 2023
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8PSD
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![BU of 8psd by Molmil](/molmil-images/mine/8psd) | SARS-CoV-2 XBB 1.0 closed conformation. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Duhoo, Y, Lau, K. | 登録日 | 2023-07-13 | 公開日 | 2023-11-01 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys. J Infect, 87, 2023
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6Y94
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![BU of 6y94 by Molmil](/molmil-images/mine/6y94) | Ca2+-bound Calmodulin mutant N53I | 分子名称: | CALCIUM ION, Calmodulin | 著者 | Holt, C, Nielsen, L.H, Lau, K, Brohus, M, Sorensen, A.B, Larsen, K.T, Sommer, C, Petegem, F.V, Overgaard, M.T, Wimmer, R. | 登録日 | 2020-03-06 | 公開日 | 2020-04-29 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor. J.Biol.Chem., 295, 2020
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6Y95
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![BU of 6y95 by Molmil](/molmil-images/mine/6y95) | Ca2+-free Calmodulin mutant N53I | 分子名称: | Calmodulin | 著者 | Holt, C, Hamborg, L.N, Lau, K, Brohus, M, Sorensen, A.B, Larsen, K.T, Sommer, C, Petegem, F.V, Overgaard, M.T, Wimmer, R. | 登録日 | 2020-03-06 | 公開日 | 2020-04-29 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor. J.Biol.Chem., 295, 2020
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4ETU
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![BU of 4etu by Molmil](/molmil-images/mine/4etu) | |
4ETT
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![BU of 4ett by Molmil](/molmil-images/mine/4ett) | |
4ETV
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![BU of 4etv by Molmil](/molmil-images/mine/4etv) | |
4ERT
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![BU of 4ert by Molmil](/molmil-images/mine/4ert) | |
4ESU
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![BU of 4esu by Molmil](/molmil-images/mine/4esu) | |
4ERV
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![BU of 4erv by Molmil](/molmil-images/mine/4erv) | |
8PI3
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![BU of 8pi3 by Molmil](/molmil-images/mine/8pi3) | Cathepsin S Y132D mutant in complex with NNPI-C10 inhibitor | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CADMIUM ION, ... | 著者 | Petruzzella, A, Lau, K, Pojer, F, Oricchio, E. | 登録日 | 2023-06-21 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins. Nat.Chem.Biol., 2024
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8RND
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![BU of 8rnd by Molmil](/molmil-images/mine/8rnd) | Cathepsin S in complex with NNPI-C10 inhibitor | 分子名称: | 1,2-ETHANEDIOL, Cathepsin S, DI(HYDROXYETHYL)ETHER, ... | 著者 | Petruzzella, A, Lau, K, Pojer, F, Oricchio, E. | 登録日 | 2024-01-09 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins. Nat.Chem.Biol., 2024
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6RRT
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![BU of 6rrt by Molmil](/molmil-images/mine/6rrt) | T=4 MS2 Virus-like-particle | 分子名称: | Capsid protein | 著者 | de Martin Garrido, N, Ramlaul, K, Simpson, P.A, Crone, M.A, Freemont, P.S, Aylett, C.H.S. | 登録日 | 2019-05-20 | 公開日 | 2020-07-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | Bacteriophage MS2 displays unreported capsid variability assembling T = 4 and mixed capsids. Mol.Microbiol., 113, 2020
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6RRS
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![BU of 6rrs by Molmil](/molmil-images/mine/6rrs) | T=3 MS2 Virus-like particle | 分子名称: | Capsid protein | 著者 | de Martin Garrido, N, Ramlaul, K, Simpson, P.A, Crone, M.A, Freemont, P.S, Aylett, C.H.S. | 登録日 | 2019-05-20 | 公開日 | 2020-07-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Bacteriophage MS2 displays unreported capsid variability assembling T = 4 and mixed capsids. Mol.Microbiol., 113, 2020
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6TLB
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![BU of 6tlb by Molmil](/molmil-images/mine/6tlb) | Plasmodium falciparum lipocalin (PF3D7_0925900) | 分子名称: | GLYCEROL, SODIUM ION, Serine/threonine protein kinase | 著者 | Burda, P.C, Crosskey, T.D, Lauk, K, Wilmanns, M, Gilberger, T.W. | 登録日 | 2019-12-02 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | SOLUTION SCATTERING (2.85 Å), X-RAY DIFFRACTION | 主引用文献 | Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum. Cell Rep, 31, 2020
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