6Y95
Ca2+-free Calmodulin mutant N53I
Summary for 6Y95
| Entry DOI | 10.2210/pdb6y95/pdb |
| NMR Information | BMRB: 34497 |
| Descriptor | Calmodulin (1 entity in total) |
| Functional Keywords | mutant, metal-binding, signaling protein, cpvt, metal binding protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 16720.40 |
| Authors | Holt, C.,Hamborg, L.N.,Lau, K.,Brohus, M.,Sorensen, A.B.,Larsen, K.T.,Sommer, C.,Petegem, F.V.,Overgaard, M.T.,Wimmer, R. (deposition date: 2020-03-06, release date: 2020-04-29, Last modification date: 2023-06-14) |
| Primary citation | Holt, C.,Hamborg, L.,Lau, K.,Brohus, M.,Sorensen, A.B.,Larsen, K.T.,Sommer, C.,Van Petegem, F.,Overgaard, M.T.,Wimmer, R. The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor. J.Biol.Chem., 295:7620-7634, 2020 Cited by PubMed: 32317284DOI: 10.1074/jbc.RA120.013430 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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