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Structure of U2AF65 variant with BrU3C5 DNA
分子名称:	1,4-DIETHYLENE DIOXIDE, DNA 5'-D(UPUP(BRU)PUPCPUP*U)-3', GLYCEROL, ...
著者	Jenkins, J.L, Frato, K.H, Kielkopf, C.L.
登録日	2011-12-29
公開日	2013-02-13
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs. Nucleic Acids Res., 41, 2013

1XCB

X-ray Structure of a Rex-Family Repressor/NADH Complex from Thermus Aquaticus
分子名称:	CALCIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Redox-sensing transcriptional repressor rex
著者	Sickmier, E.A, Brekasis, D, Paranawithana, S, Bonanno, J.B, Burley, S.K, Paget, M.S, Kielkopf, C.L, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日	2004-09-01
公開日	2004-09-28
最終更新日	2021-02-03
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	X-Ray Structure of a Rex-Family Repressor/NADH Complex: Insights into the Mechanism of Redox Sensing Structure, 13, 2005

5W0H

Structure of U2AF65 (U2AF2) RRM2 at 1.11 Angstrom Resolution
分子名称:	Splicing factor U2AF 65 kDa subunit
著者	Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日	2017-05-30
公開日	2018-04-11
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.11 Å)
主引用文献	Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs. Biochemistry, 56, 2017

7S3B

Crystal structure of intact U2AF65 RRM-region bound to AdML-G5 oligonucleotide
分子名称:	DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(PUPUP(UD)PGPU)-D(P(BRU))-R(PCPC)-3'), Splicing factor U2AF 65 kDa subunit
著者	Jenkins, J.L, Henderson, S, Kielkopf, C.L.
登録日	2021-09-05
公開日	2022-05-25
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.89 Å)
主引用文献	Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50, 2022

7S3C

Crystal structure of intact U2AF65 RRM-region bound to AdML-A5 oligonucleotide
分子名称:	DNA/RNA (5'-R(PUPUP(UD)PAPU)-D(P(BRU))-R(PCPC)-3'), Splicing factor U2AF 65 kDa subunit
著者	Glasser, E, Jenkins, J.L, Kielkopf, C.L.
登録日	2021-09-05
公開日	2022-05-25
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.51 Å)
主引用文献	Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50, 2022

4TU9

STRUCTURE OF U2AF65 VARIANT WITH BRU5G6 DNA
分子名称:	1,4-DIETHYLENE DIOXIDE, DNA (5'-D(UPUPUPUP(BRU)PDG*U)-3'), GLYCEROL, ...
著者	Jenkins, J.L, McLaughlin, K.J, Agrawal, A.A, Kielkopf, C.L.
登録日	2014-06-24
公開日	2014-11-26
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (1.992 Å)
主引用文献	Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proc.Natl.Acad.Sci.USA, 111, 2014

4TU8

STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA
分子名称:	1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(UPUPUPUP(BRU)PDA*U)-3'), ...
著者	MCLAUGHLIN, K.J, JENKINS, J.L, Agrawal, A.A, KIELKOPF, C.L.
登録日	2014-06-24
公開日	2014-11-26
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (1.918 Å)
主引用文献	Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proc.Natl.Acad.Sci.USA, 111, 2014

4TU7

Structure of U2AF65 D231V variant with BrU5 DNA
分子名称:	1,4-DIETHYLENE DIOXIDE, DNA (5'-D(UPUPUPUP(BRU)PUP*U)-3'), GLYCEROL, ...
著者	Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日	2014-06-24
公開日	2014-11-26
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.087 Å)
主引用文献	Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proc.Natl.Acad.Sci.USA, 111, 2014

5EV1

Structure I of Intact U2AF65 Recognizing a 3' Splice Site Signal
分子名称:	DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(UPUPU)-D(PUPUP(BRU)PU)-R(PUP*U)-3'), SODIUM ION, ...
著者	Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日	2015-11-19
公開日	2016-02-24
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.037 Å)
主引用文献	An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun, 7, 2016

5EV2

Structure II of Intact U2AF65 Recognizing the 3' Splice Site Signal
分子名称:	1,4-DIETHYLENE DIOXIDE, DI(HYDROXYETHYL)ETHER, DNA (5'-R(PUPU)-D(PUPU)-R(PU)-D(PUP(BRU)PU)-3'), ...
著者	Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日	2015-11-19
公開日	2016-02-24
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (1.86 Å)
主引用文献	An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun, 7, 2016

5EV3

Structure III of Intact U2AF65 Recognizing the 3' Splice Site Signal
分子名称:	DNA/RNA (5'-R(PUPU)-D(PU)-R(PUPU)-D(P(BRU)PUPU)-3'), Splicing factor U2AF 65 kDa subunit
著者	Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日	2015-11-19
公開日	2016-02-24
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun, 7, 2016

5EV4

Structure IV of Intact U2AF65 Recognizing the 3' Splice Site Signal
分子名称:	DNA/RNA (5'-R(PUPUPUP(UD)PUPU)-D(P(BRU)P(UD))-R(P*C)-3'), GLYCEROL, Splicing factor U2AF 65 kDa subunit
著者	Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日	2015-11-19
公開日	2016-02-24
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (1.57 Å)
主引用文献	An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun, 7, 2016

6N3D

Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State)
分子名称:	CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者	Loerch, S, Jenkins, J.L, Kielkopf, C.L.
登録日	2018-11-15
公開日	2019-01-02
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (1.13 Å)
主引用文献	The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019

6NSX

Yeast Hsh155 Ligand bound to Human Tat-SF1 Motif
分子名称:	CHLORIDE ION, HIV Tat-specific factor 1, Hsh155
著者	Jenkins, J.L, Leach, J.R, Kielkopf, C.L.
登録日	2019-01-25
公開日	2019-06-05
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction. Rna, 25, 2019

6N3F

Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5
分子名称:	DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ...
著者	Leach, J.R, Jenkins, J.L, Kielkopf, C.L.
登録日	2018-11-15
公開日	2019-01-02
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (2.099 Å)
主引用文献	The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019

6N3E

Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4
分子名称:	FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ...
著者	Loerch, S, Jenkins, J.L, Kielkopf, C.L.
登録日	2018-11-15
公開日	2019-01-02
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (1.893 Å)
主引用文献	The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019

3BS9

X-ray structure of human TIA-1 RRM2
分子名称:	IODIDE ION, Nucleolysin TIA-1 isoform p40
著者	Kumar, A.O, Kielkopf, C.L.
登録日	2007-12-22
公開日	2008-01-15
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution. Biochem.Biophys.Res.Commun., 367, 2008

3CGR

X-ray structure containing the pseudouridylated U2 snRNA and intron branch site consensus sequences
分子名称:	RNA (5'-R(CPGPCPAPCPUPAPAPCPCPGPCPG)-3'), RNA (5'-R(GPCPGPCPGPGP(PSU)PAPGPUPGP*C)-3'), SULFATE ION
著者	Lin, Y, Kielkopf, C.L.
登録日	2008-03-06
公開日	2008-07-01
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines. Biochemistry, 47, 2008

3CGP

X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex bound to iodide ions
分子名称:	IODIDE ION, RNA (5'-R(CPGPCPUPAPCPUPAPAPCPGPCPG)-3'), RNA (5'-R(GPCPGPCPGP(PSU)PAPGPUPAPGP*C)-3'), ...
著者	Lin, Y, Kielkopf, C.L.
登録日	2008-03-06
公開日	2008-07-01
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (1.57 Å)
主引用文献	X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines. Biochemistry, 47, 2008

3CGQ

X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex
分子名称:	RNA (5'-R(CPGPCPUPAPCPUPAPAPCPGPCPG)-3'), RNA (5'-R(GPCPGPCPGP(PSU)PAPGPUPAPGP*C)-3'), SULFATE ION
著者	Lin, Y, Kielkopf, C.L.
登録日	2008-03-06
公開日	2008-07-01
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.55 Å)
主引用文献	X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines. Biochemistry, 47, 2008

3CGS

X-ray structure containing the pseudouridylated U2 snRNA and mammalian intron branch site consensus sequences
分子名称:	MAGNESIUM ION, RNA (5'-R(CPGPCPUPAPCPUPGPAPCPGPCPG)-3'), RNA (5'-R(GPCPGPCPGP(PSU)PAPGPUPAPGP*C)-3')
著者	Lin, Y, Kielkopf, C.L.
登録日	2008-03-06
公開日	2008-07-01
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines. Biochemistry, 47, 2008

6XLW

Crystal structure of U2AF65 bound to AdML splice site sequence
分子名称:	DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(PUPUP(UD)PUPU)-D(P(BRU))-R(PCPC)-3'), GLYCEROL, ...
著者	Maji, D, Jenkins, J.L, Kielkopf, C.L.
登録日	2020-06-29
公開日	2020-10-07
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. J.Biol.Chem., 295, 2020

2OKS

X-ray Structure of a DNA Repair Substrate Containing an Alkyl Interstrand Crosslink at 1.65 Resolution
分子名称:	5'-D(CPCPAPAP(C34)PGPTPTPGPG)-3', CALCIUM ION
著者	Swenson, M.C, Paranawithana, S.R, Miller, P.S, Kielkopf, C.L.
登録日	2007-01-17
公開日	2007-02-13
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Structure of a DNA repair substrate containing an alkyl interstrand cross-link at 1.65 a resolution. Biochemistry, 46, 2007

3VAG

Structure of U2AF65 variant with BrU3C2 DNA
分子名称:	1,4-DIETHYLENE DIOXIDE, DNA 5'-D(UCP(BRU)PUPUPUP*U)-3', GLYCEROL, ...
著者	Jenkins, J.L, Kielkopf, C.L.
登録日	2011-12-29
公開日	2013-02-13
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.19 Å)
主引用文献	U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs. Nucleic Acids Res., 41, 2013

4FXX

Structure of SF1 coiled-coil domain
分子名称:	IMIDAZOLE, MALONATE ION, Splicing factor 1
著者	Gupta, A, Bauer, W.J, Wang, W, Kielkopf, C.L.
登録日	2012-07-03
公開日	2013-01-16
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.4801 Å)
主引用文献	Structure of Phosphorylated SF1 Bound to U2AF(65) in an Essential Splicing Factor Complex. Structure, 21, 2013

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