1LEI
 
 | | The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV transcription | | 分子名称: | 5'-D(*CP*TP*CP*AP*GP*GP*GP*AP*AP*AP*GP*TP*AP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*5ITP*AP*CP*5ITP*5ITP*5ITP*CP*CP*CP*TP*GP*AP*G)-3', NUCLEAR FACTOR NF-KAPPA-B P50 SUBUNIT, ... | | 著者 | Chen-Park, F, Huang, D.B, Ghosh, G. | | 登録日 | 2002-04-09 | | 公開日 | 2003-04-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The kB DNA sequence from the HIV Long Terminal Repeat functions as an allosteric regulator of HIV transcription
J.Biol.Chem., 277, 2002
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1LE9
 | | Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti | | 分子名称: | 5'-D(*AP*AP*GP*GP*AP*AP*AP*GP*TP*CP*CP*C)-3', 5'-D(*TP*GP*GP*GP*AP*CP*TP*TP*TP*CP*CP*T)-3', NUCLEAR FACTOR NF-KAPPA-B P50 SUBUNIT, ... | | 著者 | Benjamin, B, Huang, D.B, Chen-Park, F.E, Sigler, P.B, Ghosh, G. | | 登録日 | 2002-04-09 | | 公開日 | 2003-04-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site.
J.Biol.Chem., 277, 2002
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1K3Z
 | | X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex | | 分子名称: | Transcription factor p65, transcription factor inhibitor I-kappa-B-beta | | 著者 | Shiva, M, Huang, D.B, Chen, Y, Huxford, T, Ghosh, S, Ghosh, G. | | 登録日 | 2001-10-04 | | 公開日 | 2002-10-04 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
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4OT9
 | | crystal structure of the C-terminal domain of p100/NF-kB2 | | 分子名称: | Nuclear factor NF-kappa-B p100 subunit, SULFATE ION | | 著者 | Tao, Z.H, Huang, D.B, Fusco, A, Gupta, K, Ware, C.F, Duynne, G.V. | | 登録日 | 2014-02-13 | | 公開日 | 2015-01-14 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | p100/I kappa B delta sequesters and inhibits NF-kappa B through kappaBsome formation.
Proc.Natl.Acad.Sci.USA, 111, 2014
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1VKX
 | | CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA | | 分子名称: | DNA (5'-D(*AP*GP*GP*AP*AP*AP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*GP*AP*CP*TP*TP*TP*CP*C)-3'), PROTEIN (NF-KAPPA B P50 SUBUNIT), ... | | 著者 | Chen, F, Huang, D.B, Ghosh, G. | | 登録日 | 1997-09-17 | | 公開日 | 1998-12-09 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA.
Nature, 391, 1998
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1LVE
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9BDU
 | | NF-kappaB RelA homo-dimer bound to AT-centric kappaB DNA | | 分子名称: | DNA (5'-D(P*AP*CP*TP*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*AP*GP*TP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*AP*CP*TP*GP*GP*AP*AP*TP*TP*TP*CP*CP*CP*AP*GP*T)-3'), SULFATE ION, ... | | 著者 | Biswas, T, Huang, D, Ghosh, G. | | 登録日 | 2024-04-12 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Transient interactions modulate the affinity of NF-kappa B transcription factors for DNA.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9BDW
 | | NF-kappaB RelA homo-dimer bound to GC-centric kappaB DNA | | 分子名称: | DNA (5'-D(P*AP*CP*TP*GP*GP*GP*AP*AP*GP*TP*TP*CP*CP*AP*GP*TP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*AP*CP*TP*GP*GP*AP*AP*CP*TP*TP*CP*CP*CP*AP*GP*T)-3'), SULFATE ION, ... | | 著者 | Biswas, T, Shahabi, S, Tsodikov, O.V, Huang, D, Ghosh, G. | | 登録日 | 2024-04-12 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Transient interactions modulate the affinity of NF-kappa B transcription factors for DNA.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5LVE
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9BDV
 | | NF-kappaB RelA homo-dimer bound to TA-centric kappaB DNA | | 分子名称: | DNA (5'-D(*AP*TP*CP*AP*CP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*GP*TP*GP*AP*T)-3'), SULFATE ION, ... | | 著者 | Biswas, T, Shahabi, S, Tsodikov, O.V. | | 登録日 | 2024-04-12 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Transient interactions modulate the affinity of NF-kappa B transcription factors for DNA.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9BDX
 | | NF-kappaB RelA homo-dimer bound to CG-centric kappaB DNA | | 分子名称: | DNA (5'-D(*AP*TP*CP*AP*CP*TP*GP*GP*AP*AP*GP*TP*TP*CP*CP*CP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*GP*GP*GP*AP*AP*CP*TP*TP*CP*CP*AP*GP*TP*GP*AP*T)-3'), Transcription factor p65 | | 著者 | Biswas, T, Shahabi, S, Tsodikov, O.V, Ghosh, G. | | 登録日 | 2024-04-12 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Transient interactions modulate the affinity of NF-kappa B transcription factors for DNA.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5EBZ
 | | Crystal structure of human IKK1 | | 分子名称: | 2,3-di-O-sulfo-alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose-(1-6)-2,4-di-O-sulfo-alpha-D-glucopyranose, 2-azanyl-5-phenyl-3-(4-sulfamoylphenyl)benzamide, Inhibitor of nuclear factor kappa-B kinase subunit alpha, ... | | 著者 | Polley, S, Passos, D, Huang, D, Biswas, T, Verma, I, Lyumkis, D, Ghosh, G. | | 登録日 | 2015-10-20 | | 公開日 | 2016-11-02 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | | 主引用文献 | Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
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5U01
 | | Cooperative DNA binding by two RelA dimers | | 分子名称: | DNA (27-MER), Transcription factor p65 | | 著者 | Ghosh, G, Huang, D. | | 登録日 | 2016-11-22 | | 公開日 | 2017-09-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated.
J. Biol. Chem., 292, 2017
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5TQY
 | | CryoEM reconstruction of human IKK1, closed conformation 3 | | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit alpha | | 著者 | Lyumkis, D, Ghosh, G, Polley, S, Biswath, T, Huang, D, Passos, D.O. | | 登録日 | 2016-10-24 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | | 主引用文献 | Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
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5TQX
 | | CryoEM reconstruction of human IKK1, intermediate conformation 2 | | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit alpha | | 著者 | Lyumkis, D, Ghosh, G, Polley, S, Biswath, T, Huang, D, Passos, D.O. | | 登録日 | 2016-10-24 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
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5TQW
 | | CryoEM reconstruction of human IKK1, open conformation 1 | | 分子名称: | Inhibitor of nuclear factor kappa-B kinase subunit alpha | | 著者 | Lyumkis, D, Ghosh, G, Polley, S, Biswath, T, Huang, D, Passos, D.O. | | 登録日 | 2016-10-24 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | | 主引用文献 | Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
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1IKN
 | | IKAPPABALPHA/NF-KAPPAB COMPLEX | | 分子名称: | PROTEIN (I-KAPPA-B-ALPHA), PROTEIN (NF-KAPPA-B P50D SUBUNIT), PROTEIN (NF-KAPPA-B P65 SUBUNIT) | | 著者 | Huxford, T, Huang, D.-B, Malek, S, Ghosh, G. | | 登録日 | 1998-11-13 | | 公開日 | 1999-04-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.
Cell(Cambridge,Mass.), 95, 1998
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3LVE
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4LVE
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2LVE
 | | RECOMBINANT LEN | | 分子名称: | RLEN | | 著者 | Schiffer, M, Pokkuluri, P.R. | | 登録日 | 1998-05-13 | | 公開日 | 1999-05-18 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A domain flip as a result of a single amino-acid substitution.
Structure, 6, 1998
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