8OU6
| Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11c | 分子名称: | 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methyl-benzamide, Cereblon isoform 4, PHOSPHATE ION, ... | 著者 | Heim, C, Bischof, L, Hartmann, M.D. | 登録日 | 2023-04-21 | 公開日 | 2023-11-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J.Med.Chem., 66, 2023
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8OU7
| Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11d | 分子名称: | 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methoxy-benzamide, Cereblon isoform 4, ZINC ION | 著者 | Heim, C, Bischof, L, Hartmann, M.D. | 登録日 | 2023-04-22 | 公開日 | 2023-11-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J.Med.Chem., 66, 2023
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8OU9
| Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11e | 分子名称: | 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-oxidanyl-benzamide, Cereblon isoform 4, ZINC ION | 著者 | Heim, C, Bischof, L, Hartmann, M.D. | 登録日 | 2023-04-22 | 公開日 | 2023-11-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J.Med.Chem., 66, 2023
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8OUA
| Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11f | 分子名称: | 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(fluoranyl)-3-methoxy-benzamide, Cereblon isoform 4, PHOSPHATE ION, ... | 著者 | Heim, C, Bischof, L, Hartmann, M.D. | 登録日 | 2023-04-22 | 公開日 | 2023-11-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J.Med.Chem., 66, 2023
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6U1Q
| Crystal Structure of VpsO (VC0937) Kinase domain | 分子名称: | O-PHOSPHOTYROSINE, VpsO | 著者 | Tripathi, S.M, Schwechheimer, C, Herbert, K, Porcella, M.E, Brown, E.R, Yildiz, F.H, Rubin, S.M. | 登録日 | 2019-08-16 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae. Plos Pathog., 16, 2020
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6U1P
| Crystal structure of VpsU (VC0916) from Vibrio cholerae | 分子名称: | GLYCEROL, Low molecular weight phosphotyrosine protein phosphatase | 著者 | Tripathi, S.M, Schwechheimer, C, Herbert, K, Osorio, J, Yildiz, F.H, Rubin, S.M. | 登録日 | 2019-08-16 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | 主引用文献 | A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae. Plos Pathog., 16, 2020
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8AOQ
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 20a | 分子名称: | (3~{S})-3-(phenylsulfonylmethyl)piperidine-2,6-dione, Cereblon isoform 4, ZINC ION | 著者 | Maiwald, S, Heim, C, Hartmann, M.D. | 登録日 | 2022-08-08 | 公開日 | 2023-01-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.088 Å) | 主引用文献 | Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines. Eur.J.Med.Chem., 246, 2023
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8AOP
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 14r | 分子名称: | (3S)-3-[(3-aminophenyl)sulfanylmethyl]piperidine-2,6-dione, Cereblon isoform 4, PHOSPHATE ION, ... | 著者 | Maiwald, S, Heim, C, Hartmann, M.D. | 登録日 | 2022-08-08 | 公開日 | 2023-01-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.944 Å) | 主引用文献 | Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines. Eur.J.Med.Chem., 246, 2023
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5OH8
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Rolipram | 分子名称: | Cereblon isoform 4, ROLIPRAM, ZINC ION | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | 登録日 | 2017-07-14 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Chemical Ligand Space of Cereblon. Acs Omega, 3, 2018
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5OH2
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Pyrrolidin-2-one (Butyrolactam) | 分子名称: | Cereblon isoform 4, ZINC ION, pyrrolidin-2-one | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | 登録日 | 2017-07-14 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Chemical Ligand Space of Cereblon. Acs Omega, 3, 2018
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5OHB
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Piperidin-2-one (Valerolactam) | 分子名称: | Cereblon isoform 4, ZINC ION, piperidin-2-one | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | 登録日 | 2017-07-14 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Chemical Ligand Space of Cereblon. Acs Omega, 3, 2018
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5OH4
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Piperidine-2,6-dione (Glutarimide) | 分子名称: | Cereblon isoform 4, ZINC ION, piperidine-2,6-dione | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | 登録日 | 2017-07-14 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Chemical Ligand Space of Cereblon. Acs Omega, 3, 2018
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5OH1
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Aminoglutethimide | 分子名称: | (3~{R})-3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione, Cereblon isoform 4, S-Thalidomide, ... | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | 登録日 | 2017-07-14 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Chemical Ligand Space of Cereblon. Acs Omega, 3, 2018
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5OH9
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thiazolidine-2,4-dione | 分子名称: | 1,3-thiazole-2,4-dione, Cereblon isoform 4, ZINC ION | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | 登録日 | 2017-07-14 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Chemical Ligand Space of Cereblon. Acs Omega, 3, 2018
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5OH3
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Ethosuximide | 分子名称: | (3~{S})-3-ethyl-3-methyl-pyrrolidine-2,5-dione, Cereblon isoform 4, ZINC ION | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | 登録日 | 2017-07-14 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Chemical Ligand Space of Cereblon. Acs Omega, 3, 2018
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5OHA
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with 2-Thiohydantoin | 分子名称: | 2-sulfanylideneimidazol-4-one, Cereblon isoform 4, ZINC ION | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | 登録日 | 2017-07-14 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Chemical Ligand Space of Cereblon. Acs Omega, 3, 2018
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5OH7
| Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Imidazolidine-2,4-dione (Hydantoin) | 分子名称: | Cereblon isoform 4, ZINC ION, imidazolidine-2,4-dione | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | 登録日 | 2017-07-14 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Chemical Ligand Space of Cereblon. Acs Omega, 3, 2018
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6YK0
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6YJZ
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6YK1
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