8AOP
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 14r
Summary for 8AOP
| Entry DOI | 10.2210/pdb8aop/pdb |
| Descriptor | Cereblon isoform 4, ZINC ION, (3S)-3-[(3-aminophenyl)sulfanylmethyl]piperidine-2,6-dione, ... (5 entities in total) |
| Functional Keywords | proteolysis targeting chimera, protac, protein degradation, signaling protein |
| Biological source | Magnetospirillum gryphiswaldense MSR-1 |
| Total number of polymer chains | 3 |
| Total formula weight | 41784.30 |
| Authors | Maiwald, S.,Heim, C.,Hartmann, M.D. (deposition date: 2022-08-08, release date: 2023-01-11, Last modification date: 2024-02-07) |
| Primary citation | Krasavin, M.,Adamchik, M.,Bubyrev, A.,Heim, C.,Maiwald, S.,Zhukovsky, D.,Zhmurov, P.,Bunev, A.,Hartmann, M.D. Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines. Eur.J.Med.Chem., 246:114990-114990, 2023 Cited by PubMed: 36476642DOI: 10.1016/j.ejmech.2022.114990 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.944 Å) |
Structure validation
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