Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Pyrrolidin-2-one (Butyrolactam)

Summary for 5OH2

DescriptorCereblon isoform 4, ZINC ION, pyrrolidin-2-one, ... (4 entities in total)
Functional Keywordsteratogenicity, protein degradation, substrate recognition, ubiquitin ligase, unknown function
Biological sourceMagnetospirillum gryphiswaldense
Total number of polymer chains3
Total molecular weight41562.27
Boichenko, I.,Albrecht, R.,Lupas, A.N.,Hernandez Alvarez, B.,Hartmann, M.D. (deposition date: 2017-07-14, release date: 2018-10-10, Last modification date: 2019-09-11)
Primary citation
Boichenko, I.,Bar, K.,Deiss, S.,Heim, C.,Albrecht, R.,Lupas, A.N.,Hernandez Alvarez, B.,Hartmann, M.D.
Chemical Ligand Space of Cereblon.
Acs Omega, 3:11163-11171, 2018
PubMed: 31459225 (PDB entries with the same primary citation)
DOI: 10.1021/acsomega.8b00959
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23150 0.8% 19.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report