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Complex of ERK2 with catechol
分子名称:	AMMONIUM ION, CATECHOL, Mitogen-activated protein kinase 1, ...
著者	Kurinov, I, Malakhova, M.
登録日	2015-05-20
公開日	2016-05-25
最終更新日	2016-10-05
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer. Oncotarget, 7, 2016

3WJM

Crystal structure of Bombyx mori Sp2/Sp3 heterohexamer
分子名称:	Arylphorin, Silkworm storage protein, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Yuan, Y.A, Hou, Y.
登録日	2013-10-11
公開日	2014-09-24
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Crystal structure of Bombyx mori arylphorins reveals a 3:3 heterohexamer with multiple papain cleavage sites Protein Sci., 23, 2014

3J1E

Cryo-EM structure of 9-fold symmetric rATcpn-beta in apo state
分子名称:	Chaperonin beta subunit
著者	Zhang, K, Wang, L, Liu, Y.X, Wang, X, Gao, B, Hu, Z.J, Ji, G, Chan, K.Y, Schulten, K, Dong, Z.Y, Sun, F.
登録日	2012-02-06
公開日	2013-08-07
最終更新日	2024-02-21
実験手法	ELECTRON MICROSCOPY (8.3 Å)
主引用文献	Flexible interwoven termini determine the thermal stability of thermosomes. Protein Cell, 4, 2013

3J1B

Cryo-EM structure of 8-fold symmetric rATcpn-alpha in apo state
分子名称:	Chaperonin alpha subunit
著者	Zhang, K, Wang, L, Liu, Y.X, Wang, X, Gao, B, Hu, Z.J, Ji, G, Chan, K.Y, Schulten, K, Dong, Z.Y, Sun, F.
登録日	2012-02-06
公開日	2013-08-07
最終更新日	2024-02-21
実験手法	ELECTRON MICROSCOPY (4.9 Å)
主引用文献	Flexible interwoven termini determine the thermal stability of thermosomes. Protein Cell, 4, 2013

3J1C

Cryo-EM structure of 9-fold symmetric rATcpn-alpha in apo state
分子名称:	Chaperonin alpha subunit
著者	Zhang, K, Wang, L, Liu, Y.X, Wang, X, Gao, B, Hu, Z.J, Ji, G, Chan, K.Y, Schulten, K, Dong, Z.Y, Sun, F.
登録日	2012-02-06
公開日	2013-08-07
最終更新日	2024-02-21
実験手法	ELECTRON MICROSCOPY (9.1 Å)
主引用文献	Flexible interwoven termini determine the thermal stability of thermosomes. Protein Cell, 4, 2013

3J1F

Cryo-EM structure of 9-fold symmetric rATcpn-beta in ATP-binding state
分子名称:	ADENOSINE-5'-TRIPHOSPHATE, Chaperonin beta subunit, MAGNESIUM ION
著者	Zhang, K, Wang, L, Liu, Y.X, Wang, X, Gao, B, Hu, Z.J, Ji, G, Chan, K.Y, Schulten, K, Dong, Z.Y, Sun, F.
登録日	2012-02-06
公開日	2013-08-07
最終更新日	2024-02-21
実験手法	ELECTRON MICROSCOPY (6.2 Å)
主引用文献	Flexible interwoven termini determine the thermal stability of thermosomes. Protein Cell, 4, 2013

6WLG

Ints3 C-terminal Domain
分子名称:	Integrator complex subunit 3
著者	Li, J, Ma, X.L, Banerjee, S, Dong, Z.G.
登録日	2020-04-20
公開日	2020-12-02
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (3.111 Å)
主引用文献	Structural basis for multifunctional roles of human Ints3 C-terminal domain. J.Biol.Chem., 296, 2020

7D3D

Crystal structure of SPOP bound with a peptide
分子名称:	GLU-VAL-SER-ILE-ILE-GLN-GLY-ALA-ASP-SER-THR-THR, GLYCEROL, Speckle-type POZ protein
著者	Yang, C.-G, Gan, J.H.
登録日	2020-09-18
公開日	2020-11-18
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	A peptide binder of E3 ligase adaptor SPOP disrupts oncogenic SPOP-protein interactions in kidney cancer cells. Chin.J.Chem., 39, 2021

8PO2

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFRinsNPG [V948R]
分子名称:	1-cyclopropyl-~{N}-[3-[1-(1-propanoylazetidin-3-yl)-4-pyridin-4-yl-pyrazol-3-yl]phenyl]imidazole-4-carboxamide, Epidermal growth factor receptor
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.28 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PO0

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 12 bound to EGFRinsNPG
分子名称:	1-[3-[7-methoxy-4-[3-(3-methoxyphenyl)-1~{H}-pyrazol-4-yl]quinazolin-6-yl]oxyazetidin-1-yl]propan-1-one, Epidermal growth factor receptor
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.523 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PO3

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 18 bound to EGFR[V948R]
分子名称:	2-methyl-5-[[3-[1-[(3~{S})-1-propanoylpyrrolidin-3-yl]-4-pyridin-4-yl-pyrazol-3-yl]phenoxy]methyl]-3~{H}-isoindol-1-one, Epidermal growth factor receptor
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.13 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PO1

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 22 bound to EGFRinsNPG [V948R]
分子名称:	2-methyl-5-[[3-[1-[(3~{S},5~{R})-5-methyl-1-propanoyl-pyrrolidin-3-yl]-4-pyridin-4-yl-pyrazol-3-yl]phenoxy]methyl]-3~{H}-isoindol-1-one, Epidermal growth factor receptor, IODIDE ION
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.11 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PO4

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFR[V948R]
分子名称:	1-cyclopropyl-~{N}-[3-[1-(1-propanoylazetidin-3-yl)-4-pyridin-4-yl-pyrazol-3-yl]phenyl]imidazole-4-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, Epidermal growth factor receptor, ...
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.621 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PNZ

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 16 bound to EGFR
分子名称:	1-[(3~{S})-3-[4-(6,7-dimethoxyquinazolin-4-yl)-3-(3-methoxyphenyl)pyrazol-1-yl]pyrrolidin-1-yl]propan-1-one, Epidermal growth factor receptor
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.51 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

6PB4

The E. coli class-II CAP-dependent transcription activation complex with de novo RNA transcript at the state 2
分子名称:	ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者	Liu, B, Shi, W.
登録日	2019-06-13
公開日	2020-03-18
最終更新日	2024-03-20
実験手法	ELECTRON MICROSCOPY (4.35 Å)
主引用文献	Visualization of two architectures in class-II CAP-dependent transcription activation Plos Biol., 18, 2020

6PB5

The E. coli class-II CAP-dependent transcription activation complex at the state 1 architecture
分子名称:	ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者	Liu, B, Shi, W.
登録日	2019-06-13
公開日	2020-03-18
最終更新日	2024-03-20
実験手法	ELECTRON MICROSCOPY (4.52 Å)
主引用文献	Visualization of two architectures in class-II CAP-dependent transcription activation Plos Biol., 18, 2020

6PB6

The E. coli class-II CAP-dependent transcription activation complex at the state 2
分子名称:	ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者	Liu, B, Shi, W.
登録日	2019-06-13
公開日	2020-03-18
最終更新日	2024-05-15
実験手法	ELECTRON MICROSCOPY (4.29 Å)
主引用文献	Visualization of two architectures in class-II CAP-dependent transcription activation Plos Biol., 18, 2020

8DQ2

X-ray crystal structure of Hansschlegelia quercus lanmodulin (LanM) with lanthanum (III) bound at pH 7
分子名称:	CITRIC ACID, EF-hand domain-containing protein, LANTHANUM (III) ION, ...
著者	Jung, J.J, Lin, C.-Y, Boal, A.K.
登録日	2022-07-18
公開日	2023-06-07
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer. Nature, 618, 2023

5TP0

Human mesotrypsin in complex with diminazene
分子名称:	BERENIL, CALCIUM ION, SULFATE ION, ...
著者	Kayode, O, Soares, A, Radisky, E.S.
登録日	2016-10-19
公開日	2017-05-17
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.25 Å)
主引用文献	Small molecule inhibitors of mesotrypsin from a structure-based docking screen. PLoS ONE, 12, 2017

8FNR

X-ray crystal structure of Hansschlegelia quercus lanmodulin (LanM) with dysprosium (III) bound at pH 7
分子名称:	DYSPROSIUM ION, EF-hand domain-containing protein
著者	Jung, J.J, Lin, C.-Y, Boal, A.K.
登録日	2022-12-28
公開日	2023-06-07
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer. Nature, 618, 2023

8FNS

X-ray crystal structure of Methylorubrum extorquens AM1 lanmodulin (LanM) with neodymium (III) bound at pH 7
分子名称:	EF-hand domain-containing protein, Neodymium Ion
著者	Jung, J.J, Lin, C.-Y, Boal, A.K.
登録日	2022-12-28
公開日	2023-06-07
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.01 Å)
主引用文献	Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer. Nature, 618, 2023

4ZHK

Crystal structure of RPE65 in complex with MB-002
分子名称:	(1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ...
著者	Kiser, P.D, Palczewski, K.
登録日	2015-04-25
公開日	2015-05-27
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.09 Å)
主引用文献	Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J.Clin.Invest., 125, 2015

3G51

Structural diversity of the active conformation of the N-terminal kinase domain of p90 ribosomal S6 kinase 2
分子名称:	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-3
著者	Kurinov, I.
登録日	2009-02-04
公開日	2009-12-15
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2 Plos One, 4, 2009

5KUE

Human SeMet incorporated I141M/L146M mitochondrial calcium uniporter (residues 72-189) crystal structure with magnesium
分子名称:	1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Calcium uniporter protein, ...
著者	Mok, C.Y.M, Lee, S.K, Junop, M.S, Stathopulos, P.B.
登録日	2016-07-13
公開日	2016-09-07
最終更新日	2020-01-08
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations. Cell Chem Biol, 23, 2016

5KUI

Human mitochondrial calcium uniporter (residues 72-189) crystal structure with calcium.
分子名称:	Calcium uniporter protein, mitochondrial
著者	Mok, M.C.Y, Lee, S.K, Junop, M.S, Stathopulos, P.B.
登録日	2016-07-13
公開日	2016-09-07
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.701 Å)
主引用文献	Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations. Cell Chem Biol, 23, 2016

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