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Formation of a tyrosyl radical intermediate in Proteus mirabilis catalase by directed mutagenesis and consequences for nucleotide reactivity
分子名称:	ACETATE ION, CATALASE, PROTOPORPHYRIN IX CONTAINING FE, ...
著者	Andreoletti, P, Gambarelli, S, Gaillard, J, Sainz, G, Stojanoff, V, Jouve, H.M.
登録日	2001-07-08
公開日	2004-02-25
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Formation of a Tyrosyl Radical Intermediate in Proteus Mirabilis Catalase by Directed Mutagenesis and Consequences for Nucleotide Reactivity. Biochemistry, 40, 2001

1N8M

Solution structure of Pi4, a four disulfide bridged scorpion toxin active on potassium channels
分子名称:	Potassium channel blocking toxin 4
著者	Guijarro, J.I, M'Barek, S, Olamendi-Portugal, T, Gomez-Lagunas, F, Garnier, D, Rochat, H, Possani, L.D, Sabatier, J.M, Delepierre, M.
登録日	2002-11-21
公開日	2003-09-02
最終更新日	2022-02-23
実験手法	SOLUTION NMR
主引用文献	Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels. Protein Sci., 12, 2003

6HTO

Tryptophan lyase 'empty state'
分子名称:	3-methyl-2-indolic acid synthase, 5'-DEOXYADENOSINE, CHLORIDE ION, ...
著者	Amara, P, Mouesca, J.M, Bella, M, Martin, L, Saragaglia, C, Gambarelli, S, Nicolet, Y.
登録日	2018-10-04
公開日	2018-11-21
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Radical S-Adenosyl-l-methionine Tryptophan Lyase (NosL): How the Protein Controls the Carboxyl Radical •CO2-Migration. J.Am.Chem.Soc., 140, 2018

6HTM

X-ray structure of the tryptophan lyase NosL in complex with bound tryptamin
分子名称:	2-(1H-INDOL-3-YL)ETHANAMINE, 3-methyl-2-indolic acid synthase, 5'-DEOXYADENOSINE, ...
著者	Amara, P, Mouesca, J.M, Bella, M, Saragaglia, C, Gambarelli, S, Nicolet, Y.
登録日	2018-10-04
公開日	2018-11-21
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Radical S-Adenosyl-l-methionine Tryptophan Lyase (NosL): How the Protein Controls the Carboxyl Radical •CO2-Migration. J.Am.Chem.Soc., 140, 2018

6HTK

X-ray structure of the tryptophan lyase NosL in complex with (R)-(+)-indoline-2-carboxylate
分子名称:	1H-indole-2-carboxylic acid, 3-methyl-2-indolic acid synthase, 5'-DEOXYADENOSINE, ...
著者	Amara, P, Mouesca, J.M, Bella, M, Martin, L, Saragaglia, C, Gambarelli, S, Nicolet, Y.
登録日	2018-10-04
公開日	2018-11-21
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Radical S-Adenosyl-l-methionine Tryptophan Lyase (NosL): How the Protein Controls the Carboxyl Radical •CO2-Migration. J.Am.Chem.Soc., 140, 2018

3EPV

X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms
分子名称:	COPPER (II) ION, Nickel and cobalt resistance protein cnrR
著者	Pompidor, G, Maillard, A.P, Girard, E, Gambarelli, S, Kahn, R, Coves, J.
登録日	2008-09-30
公開日	2008-11-25
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (1.742 Å)
主引用文献	X-ray structure of the metal-sensor CnrX in both the apo- and copper-bound forms. Febs Lett., 2008

4OKP

Crystal structure of AmpC beta-lactamase in complex with the product form of 7-amino-desacetoxycephalosporanic acid
分子名称:	(2R)-2-[(R)-amino(carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者	Barelier, S.B, Shoichet, B.K.
登録日	2014-01-22
公開日	2014-05-28
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.37 Å)
主引用文献	Substrate deconstruction and the nonadditivity of enzyme recognition. J.Am.Chem.Soc., 136, 2014

1CX5

ANTISENSE DNA/RNA HYBRID CONTAINING MODIFIED BACKBONE
分子名称:	5'-D(CPGPCPGPTPT(MMT)PTPGPCPGPC), 5'-R(GPCPGPCPAPAPAPAPCPGPCPG)
著者	Yang, X, Han, X, Cross, C, Sanghvi, Y, Gao, X.
登録日	1999-08-28
公開日	1999-09-14
最終更新日	2024-05-22
実験手法	SOLUTION NMR
主引用文献	NMR structure of an antisense DNA.RNA hybrid duplex containing a 3'-CH(2)N(CH(3))-O-5' or an MMI backbone linker. Biochemistry, 38, 1999

2OEY

Solution Structure of a Designed Spirocyclic Helical Ligand Binding at a Two-Base Bulge Site in DNA
分子名称:	(1R,3A'S,10'S,10A'R)-7-METHOXY-2-OXO-10',10A'-DIHYDRO-2H,3A'H-SPIRO[NAPHTHALENE-1,3'-PENTALENO[1,2-B]NAPHTHALEN]-10'-YL 2,6-DIDEOXY-2-(METHYLAMINO)-ALPHA-D-GALACTOPYRANOSIDE, DNA (25-MER)
著者	Zhang, N, Lin, Y, Xiao, Z, Jones, G.B, Goldberg, I.H.
登録日	2007-01-01
公開日	2007-04-10
最終更新日	2023-12-27
実験手法	SOLUTION NMR
主引用文献	Solution Structure of a Designed Spirocyclic Helical Ligand Binding at a Two-Base Bulge Site in DNA. Biochemistry, 46, 2007

7K9Z

Crystal structure of SARS-CoV-2 receptor binding domain in complex with the Fab fragments of neutralizing antibodies 298 and 52
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 298 Fab Heavy Chain, 298 Fab Light Chain, ...
著者	Newton, J.C, Kucharska, I, Rujas, E, Cui, H, Julien, J.P.
登録日	2020-09-29
公開日	2020-10-28
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.95 Å)
主引用文献	Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers. Nat Commun, 12, 2021

8DNN

Crystal structure of neutralizing antibody 80 in complex with SARS-CoV-2 receptor binding domain
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 80 FAB HEAVY CHAIN, 80 FAB LIGHT CHAIN, ...
著者	Muthuraman, K, Kucharska, I, Ivanochko, D, Julien, J.P.
登録日	2022-07-11
公開日	2023-05-24
最終更新日	2023-12-06
実験手法	X-RAY DIFFRACTION (3.12 Å)
主引用文献	A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo. Sci Transl Med, 15, 2023

2Y3H

E63Q mutant of Cupriavidus metallidurans CH34 CnrXs
分子名称:	GLYCEROL, NICKEL AND COBALT RESISTANCE PROTEIN CNRR
著者	Trepreau, J, Girard, E, Maillard, A.P, de Rosny, E, Petit-Haertlein, I, Kahn, R, Coves, J.
登録日	2010-12-20
公開日	2011-03-30
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.892 Å)
主引用文献	Structural Basis for Metal Sensing by Cnrx. J.Mol.Biol., 408, 2011

2Y3B

Co-bound form of Cupriavidus metallidurans CH34 CnrXs
分子名称:	COBALT (II) ION, GLYCEROL, NICKEL AND COBALT RESISTANCE PROTEIN CNRR
著者	Trepreau, J, Girard, E, Maillard, A.P, de Rosny, E, Petit-Haertlein, I, Kahn, R, Coves, J.
登録日	2010-12-20
公開日	2011-03-30
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (1.554 Å)
主引用文献	Structural Basis for Metal Sensing by Cnrx. J.Mol.Biol., 408, 2011

2Z3S

NMR structure of AgTx2-MTX
分子名称:	AgTx2-MTX
著者	Pimentel, C, M'Barrek, S, Visan, V, Grissmer, S, Sabatier, J.M, Darbon, H, Fajloun, Z.
登録日	2007-06-06
公開日	2008-04-22
最終更新日	2020-02-26
実験手法	SOLUTION NMR
主引用文献	Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins. Protein Sci., 17, 2008

1PJV

Cobatoxin 1 from Centruroides noxius Scorpion venom: Chemical Synthesis, 3-D Structure in Solution, Pharmacology and Docking on K+ channels
分子名称:	Cobatoxin 1
著者	Mosbah, A, Jouirou, B, Visan, V, Grissmer, S, El Ayeb, M, Rochat, H, De Waard, M, Mabrouk, K, Sabatier, J.M.
登録日	2003-06-03
公開日	2004-03-09
最終更新日	2022-02-23
実験手法	SOLUTION NMR
主引用文献	Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels. Biochem.J., 377, 2004

4JC0

Crystal structure of Thermotoga maritima holo RimO in complex with pentasulfide, Northeast Structural Genomics Consortium Target VR77
分子名称:	IRON/SULFUR PENTA-SULFIDE CONNECTED CLUSTERS, Ribosomal protein S12 methylthiotransferase RimO
著者	Forouhar, F, Hussain, M, Seetharaman, J, Fang, Y, Chen, C.X, Cunningham, K, Conover, K, Ma, L.-C, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
登録日	2013-02-20
公開日	2013-04-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases. Nat.Chem.Biol., 9, 2013

6FBJ

monoclonal antibody targeting Matrix metalloproteinase 7
分子名称:	Heavy Chain, Light chain
著者	Dym, O.
登録日	2017-12-19
公開日	2019-01-30
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Novel monoclonal antibody targeting Matrix metalloproteinase 7 shows therapeutic potential against pancreatic cancer To Be Published

4E3J

Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl benzene sulfonamide boronic acid inhibitor
分子名称:	Beta-lactamase, PHOSPHATE ION, [({[4-(1H-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid
著者	Eidam, O, Shoichet, B.K.
登録日	2012-03-09
公開日	2012-09-26
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.7999 Å)
主引用文献	Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012

4E3I

Crystal structure of AmpC beta-lactamase in complex with a designed 3-carboxyl benzyl sulfonamide boronic acid inhibitor
分子名称:	3-({[(dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic acid, Beta-lactamase, PHOSPHATE ION
著者	Eidam, O, Shoichet, B.K.
登録日	2012-03-09
公開日	2012-09-26
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012

4E3L

Crystal structure of AmpC beta-lactamase in complex with a 3-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor
分子名称:	Beta-lactamase, PHOSPHATE ION, [({[3-chloro-4-(1H-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid
著者	Eidam, O, Shoichet, B.K.
登録日	2012-03-09
公開日	2012-09-26
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.43 Å)
主引用文献	Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012

4E3K

Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl pyridine sulfonamide boronic acid inhibitor
分子名称:	Beta-lactamase, PHOSPHATE ION, [({[6-(1H-tetrazol-5-yl)pyridin-3-yl]sulfonyl}amino)methyl]boronic acid
著者	Eidam, O, Shoichet, B.K.
登録日	2012-03-09
公開日	2012-09-26
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.4299 Å)
主引用文献	Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012

4E3N

Crystal structure of AmpC beta-lactamase in complex with a 2-trifluoromethyl-4-tetrazolyl benzene sulfonamide boronic acid inhibitor
分子名称:	Beta-lactamase, PHOSPHATE ION, [({[4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)methyl]boronic acid
著者	Eidam, O, Shoichet, B.K.
登録日	2012-03-09
公開日	2012-09-26
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.49 Å)
主引用文献	Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012

4E3M

Crystal structure of AmpC beta-lactamase in complex with a 2-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor
分子名称:	Beta-lactamase, PHOSPHATE ION, [({[2-chloro-4-(1H-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid
著者	Eidam, O, Shoichet, B.K.
登録日	2012-03-09
公開日	2012-09-26
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.44 Å)
主引用文献	Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012

4E3O

Crystal structure of AmpC beta-lactamase in complex with a small chloromethyl sulfonamide boronic acid inhibitor
分子名称:	({[(chloromethyl)sulfonyl]amino}methyl)boronic acid, Beta-lactamase, PHOSPHATE ION
著者	Eidam, O, Shoichet, B.K.
登録日	2012-03-09
公開日	2012-09-26
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012

2WTP

Crystal Structure of Cu-form Czce from C. metallidurans CH34
分子名称:	1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者	Haertlein, I, Girard, E, Sarret, G, Hazemann, J, Gourhant, P, Kahn, R, Coves, J.
登録日	2009-09-18
公開日	2010-08-18
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Evidence for Conformational Changes Upon Copper Binding to Cupriavidus Metallidurans Czce. Biochemistry, 49, 2010

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