4E3N

Crystal structure of AmpC beta-lactamase in complex with a 2-trifluoromethyl-4-tetrazolyl benzene sulfonamide boronic acid inhibitor

Summary for 4E3N

• Entry DOI: 10.2210/pdb4e3n/pdb
• Related: 4E3I 4E3J 4E3K 4E3L 4E3M 4E3O
• Descriptor: Beta-lactamase, [({[4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)methyl]boronic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: ampc beta-lactamase, class c, cephalosporinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 80162.90

Authors

Eidam, O.,Shoichet, B.K. (deposition date: 2012-03-09, release date: 2012-09-26, Last modification date: 2023-09-13)

• Primary citation: Eidam, O.,Romagnoli, C.,Dalmasso, G.,Barelier, S.,Caselli, E.,Bonnet, R.,Shoichet, B.K.,Prati, F.; Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo.; Proc.Natl.Acad.Sci.USA, 109:17448-17453, 2012; PubMed: 23043117; DOI: 10.1073/pnas.1208337109

Experimental method

X-RAY DIFFRACTION (1.49 Å)