4F2O
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![BU of 4f2o by Molmil](/molmil-images/mine/4f2o) | Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3 | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION | 著者 | Ahmed, A.H, Oswald, R.E. | 登録日 | 2012-05-08 | 公開日 | 2012-05-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.912 Å) | 主引用文献 | The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 2012
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4F3G
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3IL1
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![BU of 3il1 by Molmil](/molmil-images/mine/3il1) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 | 分子名称: | (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | 著者 | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | 登録日 | 2009-08-06 | 公開日 | 2009-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3ILT
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![BU of 3ilt by Molmil](/molmil-images/mine/3ilt) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide | 分子名称: | 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE, GLUTAMIC ACID, Glutamate receptor 2, ... | 著者 | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | 登録日 | 2009-08-07 | 公開日 | 2009-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.107 Å) | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3ILU
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![BU of 3ilu by Molmil](/molmil-images/mine/3ilu) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide | 分子名称: | 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | 著者 | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | 登録日 | 2009-08-07 | 公開日 | 2009-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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4Q30
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3M3L
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![BU of 3m3l by Molmil](/molmil-images/mine/3m3l) | PEPA bound to the ligand binding domain of GluA2 (flop form) | 分子名称: | 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide, GLUTAMIC ACID, Glutamate receptor 2, ... | 著者 | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | 登録日 | 2010-03-09 | 公開日 | 2010-03-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. Biochemistry, 49, 2010
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3RTW
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3RT6
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3RT8
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3RTF
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3IK6
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![BU of 3ik6 by Molmil](/molmil-images/mine/3ik6) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide | 分子名称: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | 著者 | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | 登録日 | 2009-08-05 | 公開日 | 2009-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3IJO
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![BU of 3ijo by Molmil](/molmil-images/mine/3ijo) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide | 分子名称: | (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | 著者 | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | 登録日 | 2009-08-04 | 公開日 | 2009-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3IJX
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![BU of 3ijx by Molmil](/molmil-images/mine/3ijx) | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide | 分子名称: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | 著者 | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | 登録日 | 2009-08-05 | 公開日 | 2009-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.881 Å) | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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5ELV
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![BU of 5elv by Molmil](/molmil-images/mine/5elv) | Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504-N775) in complex with glutamate and BPAM-521 at 1.92 A resolution | 分子名称: | 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, CHLORIDE ION, ... | 著者 | Krintel, C, Juknaite, L, Frydenvang, K, Kastrup, J.S. | 登録日 | 2015-11-05 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. Biophys.J., 110, 2016
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5BUU
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![BU of 5buu by Molmil](/molmil-images/mine/5buu) | Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution | 分子名称: | (3R)-7-chloro-2,3,4-trimethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, 1,2-ETHANEDIOL, GLUTAMIC ACID, ... | 著者 | Larsen, A.P, Tapken, D, Frydenvang, K, Kastrup, J.S. | 登録日 | 2015-06-04 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. Acs Chem Neurosci, 7, 2016
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