8DA7
 
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8DAA
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8DAB
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7N3T
 | | TrkA ECD complex with designed miniprotein ligand | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jude, K.M, Cao, L, Garcia, K.C. | | 登録日 | 2021-06-01 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Design of protein-binding proteins from the target structure alone.
Nature, 605, 2022
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7RAA
 | | Designed StabIL-2 seq15 | | 分子名称: | Interleukin-2, MAGNESIUM ION | | 著者 | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | | 登録日 | 2021-06-30 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Interleukin-2 superkines by computational design.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7RA9
 | | Designed StabIL-2 seq1 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION | | 著者 | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | | 登録日 | 2021-06-30 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Interleukin-2 superkines by computational design.
Proc.Natl.Acad.Sci.USA, 119, 2022
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5UTZ
 | | Human IL-2/Fab complex | | 分子名称: | Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ... | | 著者 | Jude, K.M, Garcia, K.C. | | 登録日 | 2017-02-15 | | 公開日 | 2018-07-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.747 Å) | | 主引用文献 | A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nat. Med., 24, 2018
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6BJ3
 | | TCR55 in complex with HIV(Pol448-456)/HLA-B35 | | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, HIV Pol B35 peptide, ... | | 著者 | Jude, K.M, Sibener, L.V, Garcia, K.C. | | 登録日 | 2017-11-03 | | 公開日 | 2018-07-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | | 主引用文献 | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell, 174, 2018
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6BJ2
 | | TCR589 in complex with HIV(Pol448-456)/HLA-B35 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | | 著者 | Jude, K.M, Sibener, L.V, Garcia, K.C. | | 登録日 | 2017-11-03 | | 公開日 | 2018-07-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell, 174, 2018
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6BJ8
 | | TCR55 in complex with Pep20/HLA-B35 | | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | | 著者 | Jude, K.M, Sibener, L.V, Yang, X, Garcia, K.C. | | 登録日 | 2017-11-05 | | 公開日 | 2018-07-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell, 174, 2018
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6MOH
 | | Dimeric DARPin C_R3 complex with EpoR | | 分子名称: | Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOI
 | | Dimeric DARPin C_angle_R5 complex with EpoR | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.065 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOG
 | | Dimeric DARPin C_R3 | | 分子名称: | 1,2-ETHANEDIOL, DARPin C_R3, TRIETHYLENE GLYCOL | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOE
 | | Monomeric DARPin E2 complex with EpoR | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOL
 | | Monoextended DARPin M_R12 complex with EpoR | | 分子名称: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.163 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOF
 | | Monomeric DARPin G2 complex with EpoR | | 分子名称: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOJ
 | | Dimeric DARPin A_angle_R5 complex with EpoR | | 分子名称: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.431 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOK
 | | Dimeric DARPin A_distance_R7 complex with EpoR | | 分子名称: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (5.101 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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3CYU
 | | Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon | | 分子名称: | Carbonic anhydrase 2, MoMo-2-[4-(2-(4-(methoxy)-1H-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1H-1,2,3-triazol-1-y l)propanoic acid]-cryptophane-A, PoPo-2-[4-(2-(4-(methoxy)-1H-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1H-1,2,3-triazol-1-yl)propanoic acid]-cryptophane-A, ... | | 著者 | Aaron, J.A, Jude, K.M, Di Costanzo, L, Christianson, D.W. | | 登録日 | 2008-04-26 | | 公開日 | 2008-05-27 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II.
J.Am.Chem.Soc., 130, 2008
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8ENT
 | | Interleukin-21 signaling complex with IL-21R and IL-2Rg | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Abhiraman, G.C, Jude, K.M, Garcia, K.C. | | 登録日 | 2022-09-30 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | A structural blueprint for interleukin-21 signal modulation.
Cell Rep, 42, 2023
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7R86
 | | Structure of mouse BAI1 (ADGRB1) in complex with mouse Nogo receptor (RTN4R) | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINOBENZOIC ACID, ... | | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | | 登録日 | 2021-06-26 | | 公開日 | 2021-11-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Cell, 184, 2021
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7R85
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7R84
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8G04
 | | Structure of signaling thrombopoietin-MPL receptor complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ... | | 著者 | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | | 登録日 | 2023-01-31 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
Cell, 186, 2023
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6WDP
 | | Interleukin 12 receptor subunit beta-1 | | 分子名称: | GLYCEROL, Interleukin-12 receptor subunit beta-1, SULFATE ION | | 著者 | Spangler, J.B, Thomas, C, Jude, K.M, Garcia, K.C. | | 登録日 | 2020-04-01 | | 公開日 | 2021-02-24 | | 最終更新日 | 2021-12-01 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Cell, 184, 2021
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