3O5J
 
 | | Fk1 domain of FKBP51, crystal form III | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5O
 | | Fk1 domain mutant A19T of FKBP51, crystal form III | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP5, THIOCYANATE ION | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5E
 | | Fk1 domain of FKBP51, crystal form VI | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5L
 | | Fk1 domain mutant A19T of FKBP51, crystal form I | | 分子名称: | PENTAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5Q
 | | Fk1 domain mutant A19T of FKBP51, crystal form IV, in presence of DMSO | | 分子名称: | DIMETHYL SULFOXIDE, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (0.96 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5I
 | | Fk1 domain of FKBP51, crystal form II | | 分子名称: | ACETATE ION, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5R
 | | Complex of Fk506 with the Fk1 domain mutant A19T of FKBP51 | | 分子名称: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5F
 | | Fk1 domain of FKBP51, crystal form VII | | 分子名称: | CARBONATE ION, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5M
 | | Fk1 domain mutant A19T of FKBP51, crystal form II | | 分子名称: | GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5D
 | | Crystal structure of a fragment of FKBP51 comprising the Fk1 and Fk2 domains | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3O5K
 | | Fk1 domain of FKBP51, crystal form VIII | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Bracher, A, Kozany, C, Thost, A.-K, Hausch, F. | | 登録日 | 2010-07-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta Crystallogr.,Sect.D, 67, 2011
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3HYB
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5NV3
 | | Structure of Rubisco from Rhodobacter sphaeroides in complex with CABP | | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, Ribulose bisphosphate carboxylase large chain, ... | | 著者 | Bracher, A, Milicic, G, Ciniawsky, S, Wendler, P, Hayer-Hartl, M, Hartl, F.U. | | 登録日 | 2017-05-03 | | 公開日 | 2017-07-26 | | 最終更新日 | 2017-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | | 主引用文献 | Mechanism of Enzyme Repair by the AAA(+) Chaperone Rubisco Activase.
Mol. Cell, 67, 2017
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4TW7
 | | The Fk1 domain of FKBP51 in complex with iFit4 | | 分子名称: | (1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F. | | 登録日 | 2014-06-30 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Selective inhibitors of the FK506-binding protein 51 by induced fit.
Nat.Chem.Biol., 11, 2015
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4W9P
 | | The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one | | 分子名称: | (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Pomplun, S, Wang, Y, Kirschner, K, Kozany, C, Bracher, A, Hausch, F. | | 登録日 | 2014-08-27 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs).
Angew.Chem.Int.Ed.Engl., 54, 2015
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4W9Q
 | | The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one | | 分子名称: | (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-5-ethyl-3,10-diazabicyclo[4.3.1]decan-2-one, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Pomplun, S, Wang, Y, Kirschner, K, Kozany, C, Bracher, A, Hausch, F. | | 登録日 | 2014-08-27 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs).
Angew.Chem.Int.Ed.Engl., 54, 2015
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7ZET
 | | Crystal structure of human Clusterin, crystal form I | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Clusterin, ... | | 著者 | Yuste-Checa, P, Bracher, A, Hartl, F.U. | | 登録日 | 2022-03-31 | | 公開日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of human Clusterin, crystal form I
To be published
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7ZEU
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1A8R
 | | GTP CYCLOHYDROLASE I (H112S MUTANT) IN COMPLEX WITH GTP | | 分子名称: | GTP CYCLOHYDROLASE I, GUANOSINE-5'-TRIPHOSPHATE | | 著者 | Auerbach, G, Nar, H, Bracher, A, Bacher, A, Huber, R. | | 登録日 | 1998-03-27 | | 公開日 | 1999-05-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I.
J.Mol.Biol., 326, 2003
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1A9C
 | | GTP CYCLOHYDROLASE I (C110S MUTANT) IN COMPLEX WITH GTP | | 分子名称: | GTP CYCLOHYDROLASE I, GUANOSINE-5'-TRIPHOSPHATE | | 著者 | Auerbach, G, Nar, H, Bracher, A, Bacher, A, Huber, R. | | 登録日 | 1998-04-04 | | 公開日 | 1999-05-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | GTP Cyclohydrolase I in Complex with GTP at 2.1 A Resolution
To be Published
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8R5K
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4W9O
 | | The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one | | 分子名称: | (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Pomplun, S, Wang, Y, Kirschner, K, Kozany, C, Bracher, A, Hausch, F. | | 登録日 | 2014-08-27 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs).
Angew.Chem.Int.Ed.Engl., 54, 2015
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6SAF
 | | The Fk1 domain of FKBP51 in complex with (S)-(R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl 1-((1R,4aR,8aR)-4-oxodecahydronaphthalene-1-carbonyl)piperidine-2-carboxylate | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP5, [(1~{R})-3-(3,4-dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2~{S})-1-[[(1~{R},4~{a}~{R},8~{a}~{R})-4-oxidanylidene-2,3,4~{a},5,6,7,8,8~{a}-octahydro-1~{H}-naphthalen-1-yl]carbonyl]piperidine-2-carboxylate | | 著者 | Feng, X, Sippel, C, Knaup, F, Bracher, A, Staibano, S, Romano, M.F, Hausch, F. | | 登録日 | 2019-07-16 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | A Novel Decalin-Based Bicyclic Scaffold for FKBP51-Selective Ligands.
J.Med.Chem., 63, 2020
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4TW8
 | | The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL | | 分子名称: | 2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetyl)amino]methyl}-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Peptidyl-prolyl cis-trans isomerase FKBP4 | | 著者 | Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F. | | 登録日 | 2014-06-30 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.003 Å) | | 主引用文献 | Selective inhibitors of the FK506-binding protein 51 by induced fit.
Nat.Chem.Biol., 11, 2015
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7AOT
 | | The Fk1 domain of FKBP51 in complex with (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetrone | | 分子名称: | (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetrone, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Voll, A.M, Meyners, C, Heymann, T, Merz, S, Purder, P, Bracher, A, Hausch, F. | | 登録日 | 2020-10-15 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (0.85 Å) | | 主引用文献 | Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity.
Angew.Chem.Int.Ed.Engl., 60, 2021
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