7THE
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![BU of 7the by Molmil](/molmil-images/mine/7the) | Structure of RBD directed antibody DH1042 in complex with SARS-CoV-2 spike: Local refinement of RBD-Fab interface | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DH1042 Fab Heavy Chain, DH1042 Fab Light Chain, ... | 著者 | May, A.J, Manne, K, Acharya, P. | 登録日 | 2022-01-10 | 公開日 | 2022-02-16 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Structural diversity of the SARS-CoV-2 Omicron spike. Mol.Cell, 82, 2022
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7TOW
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7TGE
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7XVE
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![BU of 7xve by Molmil](/molmil-images/mine/7xve) | Human Nav1.7 mutant class-I | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Huang, G, Wu, Q, Li, Z, Pan, X, Yan, N. | 登録日 | 2022-05-21 | 公開日 | 2022-08-10 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XVF
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![BU of 7xvf by Molmil](/molmil-images/mine/7xvf) | Nav1.7 mutant class2 | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Huang, G, Wu, Q, Li, Z, Pan, X, Yan, N. | 登録日 | 2022-05-22 | 公開日 | 2022-08-10 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7. Proc.Natl.Acad.Sci.USA, 119, 2022
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8U1X
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![BU of 8u1x by Molmil](/molmil-images/mine/8u1x) | The structure of the PP2A-B56Delta holoenzyme mutant - E197K | 分子名称: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | 著者 | Wu, C.G, Xing, Y. | 登録日 | 2023-09-04 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U89
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![BU of 8u89 by Molmil](/molmil-images/mine/8u89) | The structure of the PP2A-B56Delta holoenzyme mutant - E197K | 分子名称: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | 著者 | Wu, C.G, Xing, Y. | 登録日 | 2023-09-16 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc.Natl.Acad.Sci.USA, 121, 2024
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6J69
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![BU of 6j69 by Molmil](/molmil-images/mine/6j69) | Structure of KIBRA and Dendrin Complex | 分子名称: | Peptide from Dendrin, Protein KIBRA | 著者 | Lin, Z, Yang, Z, Ji, Z, Zhang, M. | 登録日 | 2019-01-14 | 公開日 | 2019-03-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.753 Å) | 主引用文献 | Kibra Modulates Learning and Memory via Binding to Dendrin. Cell Rep, 26, 2019
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6JFP
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![BU of 6jfp by Molmil](/molmil-images/mine/6jfp) | Crystal structure of the beta-glucosidase Bgl15 | 分子名称: | beta-D-glucopyranose, beta-glucosidase 15 | 著者 | Xie, W, Chen, R. | 登録日 | 2019-02-11 | 公開日 | 2020-02-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Engineering of beta-Glucosidase Bgl15 with Simultaneously Enhanced Glucose Tolerance and Thermostability To Improve Its Performance in High-Solid Cellulose Hydrolysis. J.Agric.Food Chem., 68, 2020
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6XAF
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![BU of 6xaf by Molmil](/molmil-images/mine/6xaf) | 1.9A crystal structure of the GTPase domain of Parkinson's disease-associated protein LRRK2 carrying R1398H | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION | 著者 | Hoang, Q.Q, Liao, J, Huang, X, Park, Y, Wu, C.X. | 登録日 | 2020-06-04 | 公開日 | 2021-06-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.968 Å) | 主引用文献 | Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2 To be Published
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7JYD
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![BU of 7jyd by Molmil](/molmil-images/mine/7jyd) | Human Liver Receptor Homolog-1 in Complex with 10CA and a Fragment of Tif2 | 分子名称: | 10-[(3aR,6R,6aR)-6-hydroxy-3-phenyl-3a-(1-phenylethenyl)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 | 著者 | D'Agostino, E.H, Mays, S.G, Ortlund, E.A. | 登録日 | 2020-08-30 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis To Be Published
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7JYE
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![BU of 7jye by Molmil](/molmil-images/mine/7jye) | Human Liver Receptor Homolog-1 in Complex with 9ChoP and a Fragment of Tif2 | 分子名称: | 9-[(3~{a}~{R},6~{R},6~{a}~{R})-6-oxidanyl-3-phenyl-3~{a}-(1-phenylethenyl)-4,5,6,6~{a}-tetrahydro-1~{H}-pentalen-2-yl]nonyl 2-(trimethyl-$l^{4}-azanyl)ethyl hydrogen phosphate, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 | 著者 | D'Agostino, E.H, Mays, S.G, Ortlund, E.A. | 登録日 | 2020-08-30 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.551 Å) | 主引用文献 | Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis To Be Published
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8JTN
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![BU of 8jtn by Molmil](/molmil-images/mine/8jtn) | Tudor domain of TDRD3 in complex with a small molecule | 分子名称: | 2-propyl-2-azoniatricyclo[7.3.0.0^{3,7}]dodeca-1(9),2,7-trien-8-amine, Tudor domain-containing protein 3 | 著者 | Chen, M, Wang, Z, Li, W, Shang, X, Liu, Y. | 登録日 | 2023-06-22 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of Tudor domain of TDRD3 in complex with a small molecule antagonist. Biochim Biophys Acta Gene Regul Mech, 1866, 2023
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8HVS
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5WSV
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![BU of 5wsv by Molmil](/molmil-images/mine/5wsv) | Crystal structure of Myosin VIIa IQ5 in complex with Ca2+-CaM | 分子名称: | CALCIUM ION, Calmodulin, SULFATE ION, ... | 著者 | Li, J, Chen, Y, Deng, Y, Lu, Q, Zhang, M. | 登録日 | 2016-12-08 | 公開日 | 2017-06-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension Structure, 25, 2017
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8I6Y
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8IAB
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![BU of 8iab by Molmil](/molmil-images/mine/8iab) | The Arabidopsis CLCa transporter bound with chloride, ATP and PIP2 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Chloride channel protein CLC-a, ... | 著者 | Yang, Z, Zhang, X, Zhang, P. | 登録日 | 2023-02-08 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids. Nat Commun, 14, 2023
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8IAD
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![BU of 8iad by Molmil](/molmil-images/mine/8iad) | The Arabidopsis CLCa transporter bound with nitrate, ATP and PIP2 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Chloride channel protein CLC-a, MAGNESIUM ION, ... | 著者 | Yang, Z, Zhang, X, Zhang, P. | 登録日 | 2023-02-08 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids. Nat Commun, 14, 2023
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5WST
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![BU of 5wst by Molmil](/molmil-images/mine/5wst) | Crystal structure of Myo7a SAH | 分子名称: | Unconventional myosin-VIIa | 著者 | Li, J, Chen, Y, Deng, Y, Lu, Q, Zhang, M. | 登録日 | 2016-12-08 | 公開日 | 2017-06-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension Structure, 25, 2017
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6N05
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![BU of 6n05 by Molmil](/molmil-images/mine/6n05) | Structure of anti-crispr protein, AcrIIC2 | 分子名称: | AcrIIC2 | 著者 | Shah, M, Thavalingham, A, Maxwell, K.L, Moraes, T.F. | 登録日 | 2018-11-06 | 公開日 | 2019-06-05 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nat Commun, 10, 2019
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8J2M
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![BU of 8j2m by Molmil](/molmil-images/mine/8j2m) | The truncated rice Na+/H+ antiporter SOS1 (1-976) in a constitutively active state | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, Na+/H+ antiporter | 著者 | Zhang, X.Y, Tang, L.H, Zhang, C.R, Nie, J.W. | 登録日 | 2023-04-14 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na + /H + antiporter. Nat.Plants, 9, 2023
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8IWO
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![BU of 8iwo by Molmil](/molmil-images/mine/8iwo) | The rice Na+/H+ antiporter SOS1 in an auto-inhibited state | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, OsSOS1 | 著者 | Zhang, X.Y, Tang, L.H, Zhang, C.R, Nie, J.W. | 登録日 | 2023-03-30 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na + /H + antiporter. Nat.Plants, 9, 2023
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6JXT
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8IFP
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![BU of 8ifp by Molmil](/molmil-images/mine/8ifp) | SARS-CoV-2 3CL protease (3CLpro) in complex with compound 1 | 分子名称: | (1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethyl-butanoyl]-6,6-dimethyl-N-[(2S)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Su, H.X, Zhao, W.F, Xie, H, Nie, T.Q, Li, M.J, Xu, Y.C. | 登録日 | 2023-02-19 | 公開日 | 2023-10-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir. Nat Commun, 14, 2023
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8IFQ
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![BU of 8ifq by Molmil](/molmil-images/mine/8ifq) | SARS-CoV-2 3CL protease (3CLpro) in complex with compound 2 | 分子名称: | (1R,2S,5S)-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Su, H.X, Zhao, W.F, Xie, H, Nie, T.Q, Li, M.J, Xu, Y.C. | 登録日 | 2023-02-19 | 公開日 | 2023-10-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir. Nat Commun, 14, 2023
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