7JYE

Human Liver Receptor Homolog-1 in Complex with 9ChoP and a Fragment of Tif2

Summary for 7JYE

• Entry DOI: 10.2210/pdb7jye/pdb
• Related: 7JYD
• Descriptor: Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, 9-[(3~{a}~{R},6~{R},6~{a}~{R})-6-oxidanyl-3-phenyl-3~{a}-(1-phenylethenyl)-4,5,6,6~{a}-tetrahydro-1~{H}-pentalen-2-yl]nonyl 2-(trimethyl-$l^{4}-azanyl)ethyl hydrogen phosphate, ... (4 entities in total)
• Functional Keywords: agonist, nuclear receptor, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 30491.31

Authors

D'Agostino, E.H.,Mays, S.G.,Ortlund, E.A. (deposition date: 2020-08-30, release date: 2022-03-02, Last modification date: 2023-10-18)

• Primary citation: D'Agostino, E.H.,Mays, S.G.,Flynn, A.F.,Huang, X.,Wang, G.,Liu, X.,Millings, E.J.,Okafor, C.D.,Patel, A.,Cato, M.L.,Cornelison, J.C.,Houtman, R.,Moore, D.D.,Calvert, J.W.,Jui, N.T.,Ortlund, E.A.; Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.551 Å)