8QAR
 
 | | Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 98 | | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-1-[2-[4-[(4-methyl-1~{H}-pyrazol-3-yl)methyl]piperazin-1-yl]-1,3-thiazol-4-yl]-2,5,6,7-tetrahydroisoindol-4-one, Bromodomain-containing protein 4 | | 著者 | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | 登録日 | 2023-08-23 | | 公開日 | 2024-09-11 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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8QAZ
 | | Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 3 | | 分子名称: | 2-[4-[4-ethanoyl-5-methyl-3-(3-methylbutyl)-1~{H}-pyrrol-2-yl]-1,3-thiazol-2-yl]guanidine, NITRATE ION, Peregrin | | 著者 | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | 登録日 | 2023-08-23 | | 公開日 | 2024-09-11 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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8QB2
 | | Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 79 | | 分子名称: | 1-[2-methyl-4-(3-methylbutyl)-5-(2-piperazin-1-yl-1,3-thiazol-4-yl)-1~{H}-pyrrol-3-yl]ethanone, NITRATE ION, Peregrin | | 著者 | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | 登録日 | 2023-08-24 | | 公開日 | 2024-09-11 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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8QB0
 | | Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 2 | | 分子名称: | 2-[4-(3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-2~{H}-isoindol-1-yl)-1,3-thiazol-2-yl]guanidine, NITRATE ION, Peregrin | | 著者 | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | 登録日 | 2023-08-23 | | 公開日 | 2024-09-11 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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8QAL
 | | Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 83 | | 分子名称: | 1,2-ETHANEDIOL, 2-[4-(3-methyl-4-oxidanylidene-2,5,6,7-tetrahydroisoindol-1-yl)-1,3-thiazol-2-yl]guanidine, Bromodomain-containing protein 4 | | 著者 | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | 登録日 | 2023-08-23 | | 公開日 | 2024-09-11 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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6EPR
 | | The ATAD2 bromodomain in complex with compound UZH-DS15 | | 分子名称: | (~{N}~{Z},2~{R})-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-3~{H}-1,3-thiazol-2-ylidene]-1-[2-[4,4-bis(fluoranyl)cyclohexyl]ethyl]piperazine-2-carboxamide, ATPase family AAA domain-containing protein 2, SULFATE ION | | 著者 | Sledz, P, Caflisch, A. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | | 主引用文献 | Hitting a moving target: simulation and crystallography study of ATAD2 bromodomain blockers
To Be Published
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6EPW
 | | The ATAD2 bromodomain in complex with compound UZH-DU32 | | 分子名称: | (2~{R})-~{N}-[5-[3,5-bis(oxidanyl)phenyl]-4-ethanoyl-1,3-thiazol-2-yl]-2-carbamimidamido-propanamide, ATPase family AAA domain-containing protein 2, SULFATE ION | | 著者 | Sledz, P, Caflisch, A. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-31 | | 最終更新日 | 2025-04-09 | | 実験手法 | X-RAY DIFFRACTION (1.924 Å) | | 主引用文献 | Hitting a moving target: simulation and crystallography study of ATAD2 bromodomain blockers
To Be Published
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5E0R
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6QST
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