2PTK
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![BU of 2ptk by Molmil](/molmil-images/mine/2ptk) | CHICKEN SRC TYROSINE KINASE | 分子名称: | TYROSINE-PROTEIN KINASE TRANSFORMING PROTEIN SRC | 著者 | Williams, J.C, Wierenga, R. | 登録日 | 1997-06-17 | 公開日 | 1997-12-24 | 最終更新日 | 2018-04-11 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions J.Mol.Biol., 274, 1997
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6TE6
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![BU of 6te6 by Molmil](/molmil-images/mine/6te6) | Crystal structure of Dot1L in complex with an inhibitor (compound 3). | 分子名称: | Histone-lysine N-methyltransferase, H3 lysine-79 specific, ~{N}1-[(~{S})-(3-chlorophenyl)-pyridin-2-yl-methyl]-4-methylsulfonyl-~{N}2-pyrimidin-2-yl-benzene-1,2-diamine | 著者 | Scheufler, C, Stauffer, F, Be, C, Moebitz, H. | 登録日 | 2019-11-11 | 公開日 | 2019-12-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | New Potent DOT1L Inhibitors forin VivoEvaluation in Mouse. Acs Med.Chem.Lett., 10, 2019
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7Q6Y
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![BU of 7q6y by Molmil](/molmil-images/mine/7q6y) | The X-ray crystal structure of CbTan2, a tannase enzyme from Clostridium butyricum | 分子名称: | 1,2-ETHANEDIOL, Alpha/beta hydrolase, DI(HYDROXYETHYL)ETHER | 著者 | Coleman, T, Mazurkewich, S, Larsbrink, J. | 登録日 | 2021-11-09 | 公開日 | 2022-03-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structural diversity and substrate preferences of three tannase enzymes encoded by the anaerobic bacterium Clostridium butyricum. J.Biol.Chem., 298, 2022
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1W10
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![BU of 1w10 by Molmil](/molmil-images/mine/1w10) | Urokinase type plasminogen activator | 分子名称: | N-(ISOBUTOXYCARBONYL)-D-SERYL-N-((1S)-4-{[AMINO(IMINO)METHYL]AMINO}-1-FORMYLBUTYL)-L-ALANINAMIDE, SULFATE ION, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | 著者 | Jacob, U. | 登録日 | 2004-06-15 | 公開日 | 2008-05-20 | 最終更新日 | 2019-09-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors. J.Mol.Biol., 328, 2003
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1W11
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![BU of 1w11 by Molmil](/molmil-images/mine/1w11) | UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | N-(BENZYLSULFONYL)-D-SERYL-N-{4-[AMINO(IMINO)METHYL]BENZYL}-L-ALANINAMIDE, SULFATE ION, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | 著者 | Jacob, U. | 登録日 | 2004-06-15 | 公開日 | 2008-05-20 | 最終更新日 | 2019-10-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors. J.Mol.Biol., 328, 2003
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1W13
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![BU of 1w13 by Molmil](/molmil-images/mine/1w13) | UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | N-(BENZYLSULFONYL)-D-SERYL-N-(4-{[AMINO(IMINO)METHYL]AMINO}BENZYL)-L-ALANINAMIDE, SULFATE ION, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | 著者 | Jacob, U. | 登録日 | 2004-06-15 | 公開日 | 2008-05-20 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors. J.Mol.Biol., 328, 2003
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1LKT
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1W12
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![BU of 1w12 by Molmil](/molmil-images/mine/1w12) | UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | N-((1S)-4-{[AMINO(IMINO)METHYL]AMINO}-1-FORMYLBUTYL)-2-{(3R)-3-[(BENZYLSULFONYL)AMINO]-2-OXO-5-PHENYL-2,3-DIHYDRO-1H-1,4-BENZODIAZEPIN-1-YL}ACETAMIDE, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | 著者 | Jacob, U. | 登録日 | 2004-06-15 | 公開日 | 2008-05-20 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors. J.Mol.Biol., 328, 2003
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1W0Z
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![BU of 1w0z by Molmil](/molmil-images/mine/1w0z) | Urokinase type plasminogen activator | 分子名称: | N-(BUTYLSULFONYL)-D-SERYL-N-{4-[AMINO(IMINO)METHYL]BENZYL}-L-ALANINAMIDE, SULFATE ION, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | 著者 | Jacob, U. | 登録日 | 2004-06-15 | 公開日 | 2008-05-20 | 最終更新日 | 2019-09-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors. J.Mol.Biol., 328, 2003
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1W14
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![BU of 1w14 by Molmil](/molmil-images/mine/1w14) | UROKINASE TYPE PLASMINOGEN ACTIVATOR | 分子名称: | N-[(2-PHENYLETHYL)SULFONYL]-D-SERYL-N-[(1S)-4-[(DIAMINOMETHYLENE)AMINO]-1-(HYDROXYMETHYL)BUTYL]-L-ALANINAMIDE, SULFATE ION, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | 著者 | Jacob, U. | 登録日 | 2004-06-15 | 公開日 | 2008-05-20 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors. J.Mol.Biol., 328, 2003
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6TEL
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![BU of 6tel by Molmil](/molmil-images/mine/6tel) | Crystal structure of Dot1L in complex with an inhibitor (compound 10). | 分子名称: | Histone-lysine N-methyltransferase, H3 lysine-79 specific, POTASSIUM ION, ... | 著者 | Scheufler, C, Stauffer, F, Be, C, Moebitz, H. | 登録日 | 2019-11-12 | 公開日 | 2019-12-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | New Potent DOT1L Inhibitors forin VivoEvaluation in Mouse. Acs Med.Chem.Lett., 10, 2019
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6TEN
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![BU of 6ten by Molmil](/molmil-images/mine/6ten) | Crystal structure of Dot1L in complex with an inhibitor (compound 11). | 分子名称: | 3-[(4-azanyl-6-methoxy-1,3,5-triazin-2-yl)amino]-4-[[(~{S})-[2,2-bis(fluoranyl)-1,3-benzodioxol-4-yl]-(3-chloranylpyridin-2-yl)methyl]amino]benzenesulfonamide, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... | 著者 | Scheufler, C, Stauffer, F, Be, C, Moebitz, H. | 登録日 | 2019-11-12 | 公開日 | 2019-12-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | New Potent DOT1L Inhibitors forin VivoEvaluation in Mouse. Acs Med.Chem.Lett., 10, 2019
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2LXH
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![BU of 2lxh by Molmil](/molmil-images/mine/2lxh) | NMR structure of the RING domain in ubiquitin ligase gp78 | 分子名称: | E3 ubiquitin-protein ligase AMFR, ZINC ION | 著者 | Das, R, Linag, Y, Mariano, J, Li, J, Huang, T, King, A, Weissman, A, Ji, X, Byrd, R. | 登録日 | 2012-08-27 | 公開日 | 2013-08-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine. Embo J., 32, 2013
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2LXP
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![BU of 2lxp by Molmil](/molmil-images/mine/2lxp) | NMR structure of two domains in ubiquitin ligase gp78, RING and G2BR, bound to its conjugating enzyme Ube2g | 分子名称: | E3 ubiquitin-protein ligase AMFR, Ubiquitin-conjugating enzyme E2 G2, ZINC ION | 著者 | Das, R, Linag, Y, Mariano, J, Li, J, Huang, T, King, A, Weissman, A, Ji, X, Byrd, R. | 登録日 | 2012-08-30 | 公開日 | 2013-08-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine. Embo J., 32, 2013
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3GJO
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3G3Q
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3G3O
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![BU of 3g3o by Molmil](/molmil-images/mine/3g3o) | |
3G3U
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3G3T
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![BU of 3g3t by Molmil](/molmil-images/mine/3g3t) | Crystal structure of a eukaryotic polyphosphate polymerase in complex with orthophosphate | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, Vacuolar transporter chaperone 4 | 著者 | Lenherr, E.D, Hothorn, M, Scheffzek, K. | 登録日 | 2009-02-02 | 公開日 | 2009-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science, 324, 2009
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3G3R
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3PYH
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![BU of 3pyh by Molmil](/molmil-images/mine/3pyh) | Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor | 分子名称: | 3-(3-carbamimidoylphenyl)-N-(2'-sulfamoylbiphenyl-4-yl)-1,2-oxazole-4-carboxamide, CALCIUM ION, CHLORIDE ION, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2010-12-13 | 公開日 | 2011-12-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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3PMJ
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![BU of 3pmj by Molmil](/molmil-images/mine/3pmj) | Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor | 分子名称: | CALCIUM ION, CHLORIDE ION, Cationic trypsin, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2010-11-17 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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3PWB
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![BU of 3pwb by Molmil](/molmil-images/mine/3pwb) | Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor | 分子名称: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2010-12-08 | 公開日 | 2011-12-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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3PWC
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![BU of 3pwc by Molmil](/molmil-images/mine/3pwc) | Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2010-12-08 | 公開日 | 2011-12-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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3PLB
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![BU of 3plb by Molmil](/molmil-images/mine/3plb) | Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor | 分子名称: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2010-11-15 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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