3SP9
 
 | | Structural basis for iloprost as a dual PPARalpha/delta agonist | | 分子名称: | (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid, Peroxisome proliferator-activated receptor delta | | 著者 | Rong, H, Li, Y. | | 登録日 | 2011-07-01 | | 公開日 | 2011-07-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist.
J.Biol.Chem., 286, 2011
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6JIY
 | | Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | | 著者 | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | | 登録日 | 2019-02-24 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Modulation of cardiac ryanodine receptor 2 by calmodulin.
Nature, 572, 2019
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6JRS
 | | Structure of RyR2 (*F/A/C/L-Ca2+/Ca2+-CaM dataset) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | | 著者 | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | | 登録日 | 2019-04-05 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Modulation of cardiac ryanodine receptor 2 by calmodulin.
Nature, 572, 2019
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3RJR
 | | Crystal Structure of pro-TGF beta 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1 | | 著者 | Zhu, J.H, Shi, M.L, Springer, T.A. | | 登録日 | 2011-04-15 | | 公開日 | 2011-06-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Latent TGF-Beta structure and activation
Nature, 474, 2011
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6JV2
 | | Structure of RyR2 (P/L-Ca2+/Ca2+-CaM dataset) | | 分子名称: | CALCIUM ION, Calmodulin-1, RyR2, ... | | 著者 | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | | 登録日 | 2019-04-15 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Modulation of cardiac ryanodine receptor 2 by calmodulin.
Nature, 572, 2019
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6KNV
 | | THRb mutation with a novel agonist | | 分子名称: | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta | | 著者 | Yao, B.Q, Li, Y. | | 登録日 | 2019-08-07 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance.
Iscience, 20, 2019
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6KNW
 | | THRb mutation with a novel agonist | | 分子名称: | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta | | 著者 | Yao, B.Q, Li, Y. | | 登録日 | 2019-08-07 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance.
Iscience, 20, 2019
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7X78
 | | L-fuculose 1-phosphate aldolase | | 分子名称: | L-fuculose phosphate aldolase, MAGNESIUM ION, SULFATE ION | | 著者 | Lou, X, Zhang, Q, Bartlam, M. | | 登録日 | 2022-03-09 | | 公開日 | 2022-04-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural characterization of an L-fuculose-1-phosphate aldolase from Klebsiella pneumoniae.
Biochem.Biophys.Res.Commun., 607, 2022
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2KXS
 | | ZO1 ZU5 domain in complex with GRINL1A peptide | | 分子名称: | Tight junction protein ZO-1,Myocardial zonula adherens protein | | 著者 | Wen, W, Zhang, M. | | 登録日 | 2010-05-12 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-04-10 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Cdc42-dependent formation of the ZO-1/MRCKb complex at the leading edge controls cell migration
Embo J., 30, 2011
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5X74
 | | The crystal Structure PDE delta in complex with compound (R, R)-1g | | 分子名称: | (2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | | 著者 | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | | 登録日 | 2017-02-23 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors
J. Med. Chem., 60, 2017
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5XM8
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5X73
 | | The crystal Structure PDE delta in complex with R-p9 | | 分子名称: | (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | | 著者 | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | | 登録日 | 2017-02-23 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors
J. Med. Chem., 60, 2017
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5XM9
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5YR0
 | | Structure of Beclin1-UVRAG coiled coil domain complex | | 分子名称: | Beclin-1, UV radiation resistance associated protein | | 著者 | Pan, X, Zhao, Y, He, Y. | | 登録日 | 2017-11-08 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5XMA
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5X72
 | | The crystal Structure PDE delta in complex with (rac)-p9 | | 分子名称: | (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, (2S)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | | 著者 | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | | 登録日 | 2017-02-23 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors
J. Med. Chem., 60, 2017
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5KCX
 | | Pim-1 kinase in Complex with a Selective N-substituted 7-azaindole Inhibitor | | 分子名称: | 4-chloranyl-1-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-b]pyridine-6-carboxamide, ACETATE ION, IMIDAZOLE, ... | | 著者 | Mechin, I, McLean, L.R, Zhang, Y, Wang, R. | | 登録日 | 2016-06-07 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
Bioorg. Med. Chem. Lett., 27, 2017
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2O0U
 | | Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide | | 分子名称: | Mitogen-activated protein kinase 10, N-{3-CYANO-6-[3-(1-PIPERIDINYL)PROPANOYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDIN-2-YL}1-NAPHTHALENECARBOXAMIDE | | 著者 | Rowland, P, Somers, D. | | 登録日 | 2006-11-28 | | 公開日 | 2007-02-27 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.
Bioorg.Med.Chem.Lett., 17, 2007
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2O2U
 | | Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide | | 分子名称: | Mitogen-activated protein kinase 10, N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide | | 著者 | Somers, D, Rowland, P. | | 登録日 | 2006-11-30 | | 公開日 | 2007-02-27 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.
Bioorg.Med.Chem.Lett., 17, 2007
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7Y63
 | | ApoSIDT2-pH7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SID1 transmembrane family member 2, ... | | 著者 | Gong, D.S. | | 登録日 | 2022-06-18 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Structural insight into the human SID1 transmembrane family member 2 reveals its lipid hydrolytic activity.
Nat Commun, 14, 2023
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7Y68
 | | SIDT2-pH5.5 plus miRNA | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SID1 transmembrane family member 2, ... | | 著者 | Gong, D.S. | | 登録日 | 2022-06-18 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | | 主引用文献 | Structural insight into the human SID1 transmembrane family member 2 reveals its lipid hydrolytic activity.
Nat Commun, 14, 2023
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7Y69
 | | ApoSIDT2-pH5.5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SID1 transmembrane family member 2, ... | | 著者 | Gong, D.S. | | 登録日 | 2022-06-18 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structural insight into the human SID1 transmembrane family member 2 reveals its lipid hydrolytic activity.
Nat Commun, 14, 2023
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5GSK
 | | Crystal structure of duplex DNA3 in complex with Hg(II) and Sr(II) | | 分子名称: | DNA (5'-D(*GP*GP*TP*CP*GP*TP*CP*C)-3'), MERCURY (II) ION, STRONTIUM ION | | 著者 | Liu, H.H, Wang, R, Yao, Q.Q, Cheng, Y.Q, Yang, C, Luo, Q, Wu, B.X, Li, J.X, Ma, J.B, Sheng, J, Gan, J.H. | | 登録日 | 2016-08-16 | | 公開日 | 2017-02-08 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex
Nucleic Acids Res., 45, 2017
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5TOE
 | | Pim-1 kinase in complex with a 7-azaindole | | 分子名称: | 2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile, Serine/threonine-protein kinase pim-1 | | 著者 | Mclean, L, Mechin, I, Zhang, Y, Wang, R, Batchelor, J.D. | | 登録日 | 2016-10-17 | | 公開日 | 2017-10-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
Bioorg. Med. Chem. Lett., 27, 2017
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5TEX
 | | Pim-1 kinase in complex with a 7-azaindole | | 分子名称: | (4-{4-chloro-1-methyl-2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)methanol, IMIDAZOLE, Serine/threonine-protein kinase pim-1 | | 著者 | Mechin, I, Wang, R, Batchelor, J.D, McLean, L. | | 登録日 | 2016-09-23 | | 公開日 | 2017-10-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.149 Å) | | 主引用文献 | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
Bioorg. Med. Chem. Lett., 27, 2017
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