7L9M
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![BU of 7l9m by Molmil](/molmil-images/mine/7l9m) | Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with bivalent inhibitor GXH-II-083 | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N,N'-[(1,19-dioxo-4,7,10,13,16-pentaoxanonadecane-1,19-diyl)di(piperidine-1,4-diyl)]bis(4-{[4-({3-[(tert-butylsulfonyl)amino]-4-chlorophenyl}amino)-5-methylpyrimidin-2-yl]amino}-2-fluorobenzamide) | 著者 | Karim, M.R, Schonbrunn, E. | 登録日 | 2021-01-04 | 公開日 | 2022-01-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
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7LL4
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![BU of 7ll4 by Molmil](/molmil-images/mine/7ll4) | |
7LB3
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![BU of 7lb3 by Molmil](/molmil-images/mine/7lb3) | |
7LL5
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![BU of 7ll5 by Molmil](/molmil-images/mine/7ll5) | |
7LP0
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![BU of 7lp0 by Molmil](/molmil-images/mine/7lp0) | |
7LRK
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![BU of 7lrk by Molmil](/molmil-images/mine/7lrk) | |
7LRO
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![BU of 7lro by Molmil](/molmil-images/mine/7lro) | |
7LPK
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7L9G
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![BU of 7l9g by Molmil](/molmil-images/mine/7l9g) | Crystal structure of the second bromodomain (BD2) of human BRD2 bound to BI2536 | 分子名称: | 1,2-ETHANEDIOL, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 2, ... | 著者 | Karim, M.R, Bikowitz, M.J, Schonbrunn, E. | 登録日 | 2021-01-04 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64, 2021
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7LA9
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7N42
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![BU of 7n42 by Molmil](/molmil-images/mine/7n42) | Crystal structure of the tandem bromodomain of human TAF1 (TAF1-T) bound to ZS1-681 | 分子名称: | 1,2-ETHANEDIOL, 6-(but-3-en-1-yl)-4-[6-{1-[(R)-S-methanesulfonimidoyl]cyclopropyl}-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one, DIMETHYL SULFOXIDE, ... | 著者 | Karim, M.R, Schonbrunn, E. | 登録日 | 2021-06-03 | 公開日 | 2021-06-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the tandem bromodomain of human TAF1 (TAF1-T) bound to ZS1-681 To Be Published
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7MR9
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7MRA
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7MRB
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7MRH
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![BU of 7mrh by Molmil](/molmil-images/mine/7mrh) | |
7MRG
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![BU of 7mrg by Molmil](/molmil-images/mine/7mrg) | |
7MPH
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![BU of 7mph by Molmil](/molmil-images/mine/7mph) | GRB2 SH2 Domain with Compound 7 | 分子名称: | (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ... | 著者 | Sun, L, Schonbrunn, E. | 登録日 | 2021-05-04 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51, 2021
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7MR7
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![BU of 7mr7 by Molmil](/molmil-images/mine/7mr7) | Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-075 | 分子名称: | 1,2-ETHANEDIOL, 4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluoro-N-[1-(14-{3-[(2-{3-fluoro-4-[(piperidin-4-yl)carbamoyl]anilino}-5-methylpyrimidin-4-yl)amino]-5-[(2-methylpropane-2-sulfonyl)amino]phenyl}-14-oxo-4,7,10-trioxa-13-azatetradecanan-1-oyl)piperidin-4-yl]benzamide, Bromodomain-containing protein 4 | 著者 | Chan, A, Schonbrunn, E. | 登録日 | 2021-05-07 | 公開日 | 2022-05-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
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7MR8
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7MR5
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![BU of 7mr5 by Molmil](/molmil-images/mine/7mr5) | Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-052 | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N,N'-{oxybis[(ethane-2,1-diyl)oxy(1-oxoethane-2,1-diyl)piperidine-1,4-diyl]}bis{4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluorobenzamide} | 著者 | Chan, A, Schonbrunn, E. | 登録日 | 2021-05-07 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
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7MRC
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7MR6
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![BU of 7mr6 by Molmil](/molmil-images/mine/7mr6) | Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-082 | 分子名称: | Bromodomain-containing protein 4, N,N'-[(1,16-dioxo-4,7,10,13-tetraoxahexadecane-1,16-diyl)di(piperidine-1,4-diyl)]bis{4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluorobenzamide} | 著者 | Chan, A, Schonbrunn, E. | 登録日 | 2021-05-07 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
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7MRD
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![BU of 7mrd by Molmil](/molmil-images/mine/7mrd) | Crystal structure of the first bromodomain (BD1) of human BRDT bound to GXH-II-082 | 分子名称: | Bromodomain testis-specific protein, N,N'-[(1,16-dioxo-4,7,10,13-tetraoxahexadecane-1,16-diyl)di(piperidine-1,4-diyl)]bis{4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluorobenzamide} | 著者 | Chan, A, Schonbrunn, E. | 登録日 | 2021-05-07 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
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3NY1
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![BU of 3ny1 by Molmil](/molmil-images/mine/3ny1) | Structure of the ubr-box of the UBR1 ubiquitin ligase | 分子名称: | E3 ubiquitin-protein ligase UBR1, ZINC ION | 著者 | Matta-Camacho, E, Kozlov, G, Li, F, Gehring, K. | 登録日 | 2010-07-14 | 公開日 | 2010-08-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.085 Å) | 主引用文献 | Structural basis of substrate recognition and specificity in the N-end rule pathway. Nat.Struct.Mol.Biol., 17, 2010
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3NY2
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![BU of 3ny2 by Molmil](/molmil-images/mine/3ny2) | Structure of the ubr-box of UBR2 ubiquitin ligase | 分子名称: | E3 ubiquitin-protein ligase UBR2, ZINC ION | 著者 | Matta-Camacho, E, Kozlov, G, Li, F, Gehring, K. | 登録日 | 2010-07-14 | 公開日 | 2010-08-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Structural basis of substrate recognition and specificity in the N-end rule pathway. Nat.Struct.Mol.Biol., 17, 2010
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