7MR8

Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-076

Summary for 7MR8

• Entry DOI: 10.2210/pdb7mr8/pdb
• Descriptor: Bromodomain-containing protein 4, N-{3-[(2-{3-fluoro-4-[(piperidin-4-yl)carbamoyl]anilino}-5-methylpyrimidin-4-yl)amino]-5-[(2-methylpropane-2-sulfonyl)amino]benzoyl}-L-glutamic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromosporine, brd4, brd, bet, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15952.31

Authors

Chan, A.,Schonbrunn, E. (deposition date: 2021-05-07, release date: 2022-05-11, Last modification date: 2023-10-18)

• Primary citation: Chan, A.,Karim, R.,Schonbrunn, E.; Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-076; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.2 Å)