8TGN
 
 | | VMAT1 dimer with serotonin and reserpine | | 分子名称: | Chromaffin granule amine transporter, SEROTONIN, reserpine | | 著者 | Ye, J, Liu, B, Li, W. | | 登録日 | 2023-07-12 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGL
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8TGI
 | | VMAT1 dimer with dopamine and reserpine | | 分子名称: | Chromaffin granule amine transporter, L-DOPAMINE, reserpine | | 著者 | Ye, J, Liu, B, Li, W. | | 登録日 | 2023-07-12 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGM
 | | VMAT1 dimer with reserpine | | 分子名称: | VMAT1 dimer with reserpine, reserpine | | 著者 | Ye, J, Liu, B, Li, W. | | 登録日 | 2023-07-12 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGG
 | | VMAT1 dimer with MPP+ and reserpine | | 分子名称: | 1-methyl-4-phenylpyridin-1-ium, Chromaffin granule amine transporter, reserpine | | 著者 | Ye, J, Liu, B, Li, W. | | 登録日 | 2023-07-12 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGH
 | | VMAT1 dimer with amphetamine and reserpine | | 分子名称: | (2S)-1-phenylpropan-2-amine, Chromaffin granule amine transporter, reserpine | | 著者 | Ye, J, Liu, B, Li, W. | | 登録日 | 2023-07-12 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGK
 | | VMAT1 dimer with histamine and reserpine | | 分子名称: | Chromaffin granule amine transporter, HISTAMINE, reserpine | | 著者 | Ye, J, Liu, B, Li, W. | | 登録日 | 2023-07-12 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGJ
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3ADZ
 | | Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with intermediate PSPP | | 分子名称: | Dehydrosqualene synthase, MAGNESIUM ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E. | | 登録日 | 2010-01-31 | | 公開日 | 2010-11-24 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
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5WHZ
 | | PGDM1400-10E8v4 CODV Fab | | 分子名称: | Anti-HIV CODV-Fab Heavy chain, Anti-HIV CODV-Fab Light chain | | 著者 | Lord, D.M, Wei, R.R. | | 登録日 | 2017-07-18 | | 公開日 | 2017-10-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.549 Å) | | 主引用文献 | Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.
Science, 358, 2017
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5AFX
 | | T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1238 | | 分子名称: | FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, [1-hydroxy-2-(1-nonyl-1H-3lambda~5~-imidazol-3-yl)ethane-1,1-diyl]bis(phosphonic acid) | | 著者 | Yang, G, Oldfield, E, No, J.H. | | 登録日 | 2015-01-27 | | 公開日 | 2015-10-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation.
Antimicrob.Agents Chemother., 59, 2015
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6KYB
 | | Crystal structure of Atg18 from Saccharomyces cerevisiae | | 分子名称: | Autophagy-related protein 18 | | 著者 | Tang, D, Lei, Y, Liao, G, Chen, Q, Xu, L, Lu, K, Qi, S. | | 登録日 | 2019-09-17 | | 公開日 | 2020-09-09 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The crystal structure of Atg18 reveals a new binding site for Atg2 in Saccharomyces cerevisiae.
Cell.Mol.Life Sci., 78, 2021
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5TMG
 | | Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl]-1-phenyl-1H-1,2,3-triazole-4-carboxamide, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Snell, G.P, Behnke, C.A, Okada, K, Hideyuki, O, Sang, B.C, Lane, W. | | 登録日 | 2016-10-12 | | 公開日 | 2017-10-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor
To be published
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5AHU
 | | T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1326 | | 分子名称: | FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE, MAGNESIUM ION, ... | | 著者 | Yang, G, Oldfield, E, No, J.H. | | 登録日 | 2015-02-09 | | 公開日 | 2015-10-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation.
Antimicrob.Agents Chemother., 59, 2015
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5TMK
 | | Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor | | 分子名称: | 1-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl]-5-phenyl-1H-pyrrole-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Snell, G.P, Behnke, C.A, Okada, K, Hideyuki, O, Sang, B.C, Lane, W. | | 登録日 | 2016-10-13 | | 公開日 | 2017-10-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor
To be published
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8JLP
 | | Ralmitaront(RO-6889450)-bound hTAAR1-Gs protein complex | | 分子名称: | 5-ethyl-4-methyl-~{N}-[4-[(2~{S})-morpholin-2-yl]phenyl]-1~{H}-pyrazole-3-carboxamide, Gs, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLK
 | | Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex | | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLQ
 | | Fenoldopam-bound hTAAR1-Gs protein complex | | 分子名称: | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLN
 | | T1AM-bound hTAAR1-Gs protein complex | | 分子名称: | 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLJ
 | | T1AM-bound mTAAR1-Gs protein complex | | 分子名称: | 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLO
 | | Ulotaront(SEP-363856)-bound hTAAR1-Gs protein complex | | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLR
 | | A77636-bound hTAAR1-Gs protein complex | | 分子名称: | (1~{S},3~{R})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{H}-isochromene-5,6-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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5B0J
 | | Structure of MoeN5-Sso7d fusion protein in complex with beta-undecyl maltoside | | 分子名称: | MoeN5,DNA-binding protein 7d, UNDECYL-MALTOSIDE | | 著者 | Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T, Oldfield, E.O. | | 登録日 | 2015-10-30 | | 公開日 | 2016-03-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.
Angew.Chem.Int.Ed.Engl., 55, 2016
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5B0M
 | | Structure of MoeN5-Sso7d fusion protein in complex with beta-dodecyl maltoside | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, MoeN5,DNA-binding protein 7d | | 著者 | Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T, Oldfield, E.O. | | 登録日 | 2015-11-02 | | 公開日 | 2016-03-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.
Angew.Chem.Int.Ed.Engl., 55, 2016
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3SGV
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