5HLG
| Structure of reduced AbfR bound to DNA | 分子名称: | DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator | 著者 | Liu, G, Liu, X, Gan, J, Yang, C.G. | 登録日 | 2016-01-15 | 公開日 | 2017-01-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR. J. Am. Chem. Soc., 139, 2017
|
|
5HLI
| Structure of Disulfide formed AbfR | 分子名称: | CHLORIDE ION, COPPER (II) ION, MarR family transcriptional regulator | 著者 | Liu, G, Liu, X, Gan, J, Yang, C.-G. | 登録日 | 2016-01-15 | 公開日 | 2017-01-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR. J. Am. Chem. Soc., 139, 2017
|
|
2ZBB
| P43 crystal of DctBp | 分子名称: | C4-dicarboxylate transport sensor protein dctB, MALONIC ACID | 著者 | Zhou, Y.F, Nan, B.Y, Liu, X, Nan, J, Liang, Y.H, Panjikar, S, Ma, Q.J, Wang, Y.P, Su, X.-D. | 登録日 | 2007-10-18 | 公開日 | 2008-11-18 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | crystal structures of sensory histidine kinase DctBp to be published
|
|
6U4Y
| |
8B56
| Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the inhibitor GD-9 | 分子名称: | (2~{S})-4-(2-chloranylethanoyl)-1-(3,4-dichlorophenyl)-~{N}-(thiophen-2-ylmethyl)piperazine-2-carboxamide, 3C-like proteinase nsp5, BROMIDE ION, ... | 著者 | Straeter, N, Muller, C.E, Claff, T, Sylvester, K, Weisse, R, Gao, S, Song, L, Liu, X, Zhan, P. | 登録日 | 2022-09-21 | 公開日 | 2023-08-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.823 Å) | 主引用文献 | Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors. J.Med.Chem., 65, 2022
|
|
3LEH
| |
3WFV
| HIV-1 CRF07 gp41 | 分子名称: | Envelope glycoprotein gp160 | 著者 | Du, J, Xue, H, Ma, J, Liu, F, Zhou, J, Shao, Y, Qiao, W, Liu, X. | 登録日 | 2013-07-24 | 公開日 | 2013-10-16 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat Virology, 446, 2013
|
|
4KFP
| Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | 分子名称: | 1,2-ETHANEDIOL, N-(4-{[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]sulfonyl}benzyl)-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Dragovich, P.S, Bair, K.W, Baumeister, T, Ho, Y, Liederer, B.M, Liu, X, O'Brien, T, Oeh, J, Sampath, D, Skelton, N, Wang, L, Wang, W, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X. | 登録日 | 2013-04-27 | 公開日 | 2013-08-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
|
|
6M03
| The crystal structure of COVID-19 main protease in apo form | 分子名称: | 3C-like proteinase | 著者 | Zhang, B, Zhao, Y, Jin, Z, Liu, X, Yang, H, Rao, Z. | 登録日 | 2020-02-19 | 公開日 | 2020-03-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
3PFT
| Crystal Structure of Untagged C54A Mutant Flavin Reductase (DszD) in Complex with FMN From Mycobacterium goodii | 分子名称: | FLAVIN MONONUCLEOTIDE, Flavin reductase | 著者 | Li, Q, Xu, P, Ma, C, Gu, L, Liu, X, Zhang, C, Li, N, Su, J, Li, B, Liu, S. | 登録日 | 2010-10-29 | 公開日 | 2011-11-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | The flavin reductase DSZD from a desulfurizing mycobacterium goodii strain: systemic manipulation and investigation based on the crystal structure To be Published
|
|
8JTS
| hOCT1 in complex with metformin in outward open conformation | 分子名称: | Metformin, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
|
|
8JU0
| hOCT1 in complex with spironolactone in inward facing occluded conformation | 分子名称: | SPIRONOLACTONE, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-23 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
|
|
8JTW
| hOCT1 in complex with nb5660 in inward facing partially open 1 conformation | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
|
|
8JTX
| hOCT1 in complex with nb5660 in inward facing fully open conformation | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
|
|
8JTZ
| hOCT1 in complex with spironolactone in outward facing partially occluded conformation | 分子名称: | SPIRONOLACTONE, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
|
|
8JTT
| hOCT1 in complex with metformin in outward occluded conformation | 分子名称: | Metformin, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
|
|
8JTY
| hOCT1 in complex with nb5660 in inward facing partially open 2 conformation | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
|
|
8JTV
| hOCT1 in complex with metformin in inward occluded conformation | 分子名称: | Metformin, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
|
|
1Q2R
| Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate | 分子名称: | 9-DEAZAGUANINE, Queuine tRNA-ribosyltransferase, RNA (5'-R(*AP*GP*CP*AP*CP*GP*GP*CP*UP*(N)P*UP*AP*AP*AP*CP*CP*GP*UP*GP*C)-3'), ... | 著者 | Xie, W, Liu, X, Huang, R.H. | 登録日 | 2003-07-25 | 公開日 | 2003-09-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate Nat.Struct.Biol., 10, 2003
|
|
1PUY
| 1.5 A resolution structure of a synthetic DNA hairpin with a stilbenediether linker | 分子名称: | 5'-D(*GP*TP*TP*TP*TP*GP*(S02)P*CP*AP*AP*AP*AP*C)-3', MAGNESIUM ION | 著者 | Egli, M, Tereshko, V, Murshudov, G, Sanishvili, R, Liu, X, Lewis, F.D. | 登録日 | 2003-06-25 | 公開日 | 2003-10-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Face-to-face and edge-to-face pi-pi interactions in a synthetic DNA hairpin with a stilbenediether linker J.Am.Chem.Soc., 125, 2003
|
|
5T4D
| Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, hPKD:198-703, Polycystin-2 | 著者 | Shen, P.S, Yang, X, DeCaen, P.G, Liu, X, Bulkley, D, Clapham, D.E, Cao, E. | 登録日 | 2016-08-29 | 公開日 | 2016-11-02 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell, 167, 2016
|
|
1Q2S
| Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate | 分子名称: | 5'-R(*AP*GP*CP*AP*CP*GP*GP*CP*UP*(PQ1)P*UP*AP*AP*AP*CP*CP*GP*UP*GP*C)-3', 9-DEAZAGUANINE, Queuine tRNA-ribosyltransferase, ... | 著者 | Xie, W, Liu, X, Huang, R.H. | 登録日 | 2003-07-25 | 公開日 | 2003-09-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate Nat.Struct.Biol., 10, 2003
|
|
3SQZ
| |
3SR7
| |
3H6X
| |