7DY7
| Discovery of Novel Small-molecule Inhibitors of PD-1/PD-L1 Axis that Promotes PD-L1 Internalization and Degradation | 分子名称: | 2-[[3-[[5-(2-methyl-3-phenyl-phenyl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methylamino]ethanol, Programmed cell death 1 ligand 1 | 著者 | Cheng, Y, Wang, T.Y, Lu, M.L, Jiang, S, Xiao, Y.B. | 登録日 | 2021-01-20 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J.Med.Chem., 65, 2022
|
|
8JMV
| |
8JMW
| Fibril form of serine peptidase Vpr | 分子名称: | S8 family serine peptidase | 著者 | Cao, Q, Cheng, Y. | 登録日 | 2023-06-05 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM. Nat Commun, 14, 2023
|
|
5JKG
| |
3C5V
| PP2A-specific methylesterase apo form (PME) | 分子名称: | Protein phosphatase methylesterase 1 | 著者 | Xing, Y, Li, Z, Chen, Y, Stock, J, Jeffrey, P.D, Shi, Y. | 登録日 | 2008-02-01 | 公開日 | 2008-04-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell(Cambridge,Mass.), 133, 2008
|
|
4V8U
| Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex. | 分子名称: | 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | 著者 | Gao, Y.G, Feng, S, Chen, Y. | 登録日 | 2012-08-28 | 公開日 | 2014-07-09 | 最終更新日 | 2019-10-30 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Crystal structure of 70S ribosome with both cognate tRNAs in the E and P sites representing an authentic elongation complex. PLoS ONE, 8, 2013
|
|
3J28
| Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | 分子名称: | 16S rRNA | 著者 | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | 登録日 | 2012-09-28 | 公開日 | 2013-01-16 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (12.9 Å) | 主引用文献 | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process Nucleic Acids Res., 41, 2013
|
|
3J2C
| Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | 分子名称: | 16S rRNA body domain, 16S rRNA head domain | 著者 | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | 登録日 | 2012-09-28 | 公開日 | 2013-01-16 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (13.2 Å) | 主引用文献 | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process Nucleic Acids Res., 41, 2013
|
|
3J29
| Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | 分子名称: | 16S rRNA | 著者 | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | 登録日 | 2012-09-28 | 公開日 | 2013-01-16 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (14 Å) | 主引用文献 | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process Nucleic Acids Res., 41, 2013
|
|
3J2F
| Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | 分子名称: | 16S rRNA | 著者 | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | 登録日 | 2012-09-28 | 公開日 | 2013-01-16 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (17.6 Å) | 主引用文献 | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process. Nucleic Acids Res., 41, 2013
|
|
5J3R
| Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, GLUTATHIONE, Monothiol glutaredoxin-6 | 著者 | Abdalla, M, Dai, Y.-N, Chi, C.-B, Cheng, W, Cao, D.-D, Zhou, K, Ali, W, Chen, Y, Zhou, C.-Z. | 登録日 | 2016-03-31 | 公開日 | 2016-10-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster Acta Crystallogr.,Sect.F, 72, 2016
|
|
3C37
| X-ray structure of the putative Zn-dependent peptidase Q74D82 at the resolution 1.7 A. Northeast Structural Genomics Consortium target GsR143A | 分子名称: | DI(HYDROXYETHYL)ETHER, Peptidase, M48 family, ... | 著者 | Kuzin, A.P, Chen, Y, Seetharaman, J, Vorobiev, S.M, Forouhar, F, Wang, D, Mao, L, Maglaqui, M, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-01-27 | 公開日 | 2008-02-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | X-ray structure of the putative Zn-dependent peptidase Q74D82 at the resolution 1.7 A. To be Published
|
|
3C4S
| Crystal structure of the Ssl0352 protein from Synechocystis sp. Northeast Structural Genomics Consortium target SgR42 | 分子名称: | Ssl0352 protein | 著者 | Vorobiev, S.M, Chen, Y, Seetharaman, J, Wang, D, Maglaqui, M, Janjua, H, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-01-30 | 公開日 | 2008-02-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of the Ssl0352 protein from Synechocystis sp. To be Published
|
|
3C3E
| Crystal structure of 2-phospho-(S)-lactate transferase from Methanosarcina mazei in complex with Fo and GDP. Northeast Structural Genomics Consortium target MaR46 | 分子名称: | 1-deoxy-1-(8-hydroxy-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-D-ribitol, 2-phospho-L-lactate transferase, GUANOSINE-5'-DIPHOSPHATE | 著者 | Forouhar, F, Abashidze, M, Xu, H, Grochowski, L.L, Seetharaman, J, Hussain, M, Kuzin, A.P, Chen, Y, Zhou, W, Xiao, R, Acton, T.B, Montelione, G.T, Galinier, A, White, R.H, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-01-28 | 公開日 | 2008-02-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Molecular insights into the biosynthesis of the f420 coenzyme. J.Biol.Chem., 283, 2008
|
|
4DKF
| Crystal Structure of Human Interleukin-34 Bound to FAb2 | 分子名称: | FAb2 Heavy Chain, FAb2 Light Chain, Interleukin-34, ... | 著者 | Ma, X, Chen, Y, Stawicki, S, Wu, Y, Bazan, J.F, Starovasnik, M.A. | 登録日 | 2012-02-03 | 公開日 | 2012-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20, 2012
|
|
4M7C
| Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2 | 分子名称: | Peptide from Structure-specific endonuclease subunit SLX4, Telomeric repeat-binding factor 2 | 著者 | Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M. | 登録日 | 2013-08-12 | 公開日 | 2013-09-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres Cell Rep, 4, 2013
|
|
4DKE
| Crystal Structure of Human Interleukin-34 Bound to FAb1.1 | 分子名称: | FAb1.1 Heavy Chain, FAb1.1 Light Chain, Interleukin-34, ... | 著者 | Ma, X, Chen, Y, Stawicki, S, Wu, Y, Bazan, J.F, Starovasnik, M.A. | 登録日 | 2012-02-03 | 公開日 | 2012-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20, 2012
|
|
4M00
| Crystal structure of the ligand binding region of staphylococcal adhesion SraP | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Serine-rich adhesin for platelets, ... | 著者 | Yang, Y.H, Jiang, Y.L, Zhang, J, Wang, L, Chen, Y, Zhou, C.Z. | 登録日 | 2013-08-01 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells Plos Pathog., 10, 2014
|
|
2KDM
| NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | 分子名称: | DESIGNED PROTEIN | 著者 | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | 登録日 | 2009-01-12 | 公開日 | 2009-12-29 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | From the Cover: A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
5BND
| |
2KDL
| NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | 分子名称: | designed protein | 著者 | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | 登録日 | 2009-01-12 | 公開日 | 2009-12-29 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
3JSR
| X-Ray structure of All0216 protein from Nostoc sp. PCC 7120 at the resolution 1.8A. Northeast Structural Genomics Consortium target NsR236 | 分子名称: | All0216 protein, POTASSIUM ION | 著者 | Kuzin, A.P, Chen, Y, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Lee, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2009-09-10 | 公開日 | 2009-09-22 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | X-Ray structure of All0216 protein from Nostoc sp. PCC 7120 at the resolution 1.8A To be Published
|
|
4X3Q
| Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with SAH | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SibL | 著者 | liu, J.S, Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. | 登録日 | 2014-12-01 | 公開日 | 2015-11-25 | 実験手法 | X-RAY DIFFRACTION (2.586 Å) | 主引用文献 | Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with SAH To Be Published, 2015
|
|
6PK0
| Crystal Structure of OXA-48 with Hydrolyzed Imipenem | 分子名称: | (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, CHLORIDE ION, GLYCEROL, ... | 著者 | Akhtar, A, Chen, Y. | 登録日 | 2019-06-28 | 公開日 | 2020-01-22 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6, 2020
|
|
4DE0
| |