7KEV
 
 | PCSK9 in complex with a cyclic peptide LDLR disruptor | 分子名称: | CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9 Propeptide, ... | 著者 | Spraggon, G, Chopra, R. | 登録日 | 2020-10-12 | 公開日 | 2021-11-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of a PCSK9-LDLR disruptor peptide with in vivo function. Cell Chem Biol, 29, 2022
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7X2H
 
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7L5B
 
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7XD2
 
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7D8T
 
 | MITF bHLHLZ complex with M-box DNA | 分子名称: | DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit | 著者 | Guo, M, Fang, P, Wang, J. | 登録日 | 2020-10-09 | 公開日 | 2021-10-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.201 Å) | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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7D8R
 
 | MITF HLHLZ structure | 分子名称: | Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit | 著者 | Guo, M, Fang, P, Wang, J. | 登録日 | 2020-10-09 | 公開日 | 2021-10-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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7D8S
 
 | MITF bHLHLZ apo structure | 分子名称: | Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit, SULFATE ION | 著者 | Guo, M, Fang, P, Wang, J. | 登録日 | 2020-10-09 | 公開日 | 2021-10-13 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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7EOD
 
 | MITF HLHLZ Delta AKE | 分子名称: | GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor | 著者 | Li, P, Liu, Z, Fang, P, Wang, J. | 登録日 | 2021-04-22 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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7BWJ
 
 | crystal structure of SARS-CoV-2 antibody with RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ... | 著者 | Wang, X, Ge, J. | 登録日 | 2020-04-14 | 公開日 | 2020-06-03 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, 584, 2020
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3SQO
 
 | PCSK9 J16 Fab complex | 分子名称: | J16 Heavy chain, J16 Light chain, PCSK9 prodomain, ... | 著者 | Strop, P. | 登録日 | 2011-07-05 | 公開日 | 2012-05-16 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates. J.Pharmacol.Exp.Ther., 340, 2012
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5FA5
 
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8HBC
 
 | Crystal structure of the CysR-CTLD3 fragment of human DEC205 | 分子名称: | Lymphocyte antigen 75 | 著者 | Kong, D, Yu, B, Hu, Z, Cheng, C, Cao, L, He, Y. | 登録日 | 2022-10-28 | 公開日 | 2023-11-01 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Interaction of human dendritic cell receptor DEC205/CD205 with keratins. J.Biol.Chem., 300, 2024
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5IQ7
 
 | Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide. | 分子名称: | 10E8-S74W Heavy Chain, 10E8-S74W Light Chain, gp41 MPER peptide | 著者 | Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D. | 登録日 | 2016-03-10 | 公開日 | 2016-04-20 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (3.2869 Å) | 主引用文献 | Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. J.Virol., 90, 2016
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3T9N
 
 | Crystal structure of a membrane protein | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Small-conductance mechanosensitive channel | 著者 | Yang, M, Zhang, X, Ge, J, Wang, J. | 登録日 | 2011-08-03 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.456 Å) | 主引用文献 | Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance Proc.Natl.Acad.Sci.USA, 109, 2012
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5IQ9
 
 | Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide. | 分子名称: | 10E8v4 Heavy Chain, 10E8v4 Light Chain, gp41 MPER peptide | 著者 | Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D. | 登録日 | 2016-03-10 | 公開日 | 2016-04-20 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. J.Virol., 90, 2016
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5IZ8
 
 | Protein-protein interaction | 分子名称: | ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein, TRIETHYLENE GLYCOL | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | 登録日 | 2016-03-25 | 公開日 | 2017-07-05 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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5IZA
 
 | Protein-protein interaction | 分子名称: | ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2, Adenomatous polyposis coli protein | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | 登録日 | 2016-03-25 | 公開日 | 2017-07-05 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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5IZ9
 
 | Protein-protein interaction | 分子名称: | ACE-GLY-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | 登録日 | 2016-03-25 | 公開日 | 2017-07-05 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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3UDC
 
 | Crystal structure of a membrane protein | 分子名称: | Small-conductance mechanosensitive channel, C-terminal peptide from Small-conductance mechanosensitive channel | 著者 | Li, W, Ge, J, Yang, M. | 登録日 | 2011-10-28 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.355 Å) | 主引用文献 | Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance Proc.Natl.Acad.Sci.USA, 109, 2012
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8X3Y
 
 | ThDP-dependent HKA synthase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BbmA, MAGNESIUM ION, ... | 著者 | Yu, J.H, Liu, T. | 登録日 | 2023-11-14 | 公開日 | 2024-11-20 | 最終更新日 | 2025-06-04 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon-carbon linkage reactions. Nat.Chem., 2025
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8X3Z
 
 | ThDP-dependent HKA synthase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CsmA, MAGNESIUM ION, ... | 著者 | Yu, J.H, Liu, T. | 登録日 | 2023-11-14 | 公開日 | 2024-11-20 | 最終更新日 | 2025-06-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon-carbon linkage reactions. Nat.Chem., 2025
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8X3X
 
 | ThDP-dependent HKA synthase | 分子名称: | 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ADENOSINE-5'-DIPHOSPHATE, BbmA, ... | 著者 | Yu, J.H, Liu, T. | 登録日 | 2023-11-14 | 公開日 | 2024-11-20 | 最終更新日 | 2025-06-04 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon-carbon linkage reactions. Nat.Chem., 2025
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6MC1
 
 | Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one, ACETATE ION, ... | 著者 | Gannam, Z.T.K, Anderson, K.S, Bennett, A.M, Lolis, E. | 登録日 | 2018-08-30 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. Sci.Signal., 13, 2020
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8XOD
 
 | ThDP-dependent HKA synthase | 分子名称: | 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(~{R})-cyclobutyl(oxidanyl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, ADENOSINE-5'-DIPHOSPHATE, BbmA-G484F complex with CBOA, ... | 著者 | Yu, J.H, Liu, T. | 登録日 | 2024-01-01 | 公開日 | 2025-01-01 | 最終更新日 | 2025-06-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon-carbon linkage reactions. Nat.Chem., 2025
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7LQV
 
 | Cryo-EM structure of NTD-directed neutralizing antibody 4-8 Fab in complex with SARS-CoV-2 S2P spike | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-8 Heavy Chain, 4-8 Light chain, ... | 著者 | Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L. | 登録日 | 2021-02-15 | 公開日 | 2021-03-24 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite Cell Host Microbe, 2021
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