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7KEV
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BU of 7kev by Molmil
PCSK9 in complex with a cyclic peptide LDLR disruptor
分子名称: CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9 Propeptide, ...
著者Spraggon, G, Chopra, R.
登録日2020-10-12
公開日2021-11-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
Cell Chem Biol, 29, 2022
7X2H
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BU of 7x2h by Molmil
Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with 6-2C Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-2C H chain, 6-2C L chain, ...
著者Wang, X, Wang, Z.
登録日2022-02-25
公開日2023-03-01
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants.
Nat Commun, 14, 2023
7L5B
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BU of 7l5b by Molmil
Crystallographic structure of neutralizing antibody 2-15 in complex with SARS-CoV-2 spike receptor-binding Domain (RBD).
分子名称: 2-15 Heavy chain, 2-15 Light Chain, Spike protein S1
著者Reddem, E.R, Shapiro, L.
登録日2020-12-21
公開日2021-02-10
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.18 Å)
主引用文献Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class.
Cell Rep, 35, 2021
7XD2
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BU of 7xd2 by Molmil
SARS-CoV-2 S ectodomain trimer in complex with neutralizing antibody 10-5B
分子名称: H chain of antibody 10-5B, L chian of antibody 10-5B, Spike glycoprotein
著者Wang, X, Wang, Z.
登録日2022-03-26
公開日2023-07-12
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants.
Nat Commun, 14, 2023
7D8T
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BU of 7d8t by Molmil
MITF bHLHLZ complex with M-box DNA
分子名称: DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit
著者Guo, M, Fang, P, Wang, J.
登録日2020-10-09
公開日2021-10-13
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.201 Å)
主引用文献A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
7D8R
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BU of 7d8r by Molmil
MITF HLHLZ structure
分子名称: Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit
著者Guo, M, Fang, P, Wang, J.
登録日2020-10-09
公開日2021-10-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
7D8S
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BU of 7d8s by Molmil
MITF bHLHLZ apo structure
分子名称: Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit, SULFATE ION
著者Guo, M, Fang, P, Wang, J.
登録日2020-10-09
公開日2021-10-13
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
7EOD
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BU of 7eod by Molmil
MITF HLHLZ Delta AKE
分子名称: GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor
著者Li, P, Liu, Z, Fang, P, Wang, J.
登録日2021-04-22
公開日2022-04-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
7BWJ
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BU of 7bwj by Molmil
crystal structure of SARS-CoV-2 antibody with RBD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ...
著者Wang, X, Ge, J.
登録日2020-04-14
公開日2020-06-03
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Human neutralizing antibodies elicited by SARS-CoV-2 infection.
Nature, 584, 2020
3SQO
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BU of 3sqo by Molmil
PCSK9 J16 Fab complex
分子名称: J16 Heavy chain, J16 Light chain, PCSK9 prodomain, ...
著者Strop, P.
登録日2011-07-05
公開日2012-05-16
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
J.Pharmacol.Exp.Ther., 340, 2012
5FA5
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BU of 5fa5 by Molmil
Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Histone H4, Methylosome protein 50, ...
著者Sprague, E.R, McNamara, J.T.
登録日2015-12-10
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science, 351, 2016
8HBC
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BU of 8hbc by Molmil
Crystal structure of the CysR-CTLD3 fragment of human DEC205
分子名称: Lymphocyte antigen 75
著者Kong, D, Yu, B, Hu, Z, Cheng, C, Cao, L, He, Y.
登録日2022-10-28
公開日2023-11-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Interaction of human dendritic cell receptor DEC205/CD205 with keratins.
J.Biol.Chem., 300, 2024
5IQ7
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BU of 5iq7 by Molmil
Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide.
分子名称: 10E8-S74W Heavy Chain, 10E8-S74W Light Chain, gp41 MPER peptide
著者Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D.
登録日2016-03-10
公開日2016-04-20
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.2869 Å)
主引用文献Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
J.Virol., 90, 2016
3T9N
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BU of 3t9n by Molmil
Crystal structure of a membrane protein
分子名称: DODECYL-BETA-D-MALTOSIDE, Small-conductance mechanosensitive channel
著者Yang, M, Zhang, X, Ge, J, Wang, J.
登録日2011-08-03
公開日2012-10-31
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.456 Å)
主引用文献Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance
Proc.Natl.Acad.Sci.USA, 109, 2012
5IQ9
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BU of 5iq9 by Molmil
Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide.
分子名称: 10E8v4 Heavy Chain, 10E8v4 Light Chain, gp41 MPER peptide
著者Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D.
登録日2016-03-10
公開日2016-04-20
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
J.Virol., 90, 2016
5IZ8
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BU of 5iz8 by Molmil
Protein-protein interaction
分子名称: ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein, TRIETHYLENE GLYCOL
著者Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J.
登録日2016-03-25
公開日2017-07-05
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
5IZA
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BU of 5iza by Molmil
Protein-protein interaction
分子名称: ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2, Adenomatous polyposis coli protein
著者Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J.
登録日2016-03-25
公開日2017-07-05
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
5IZ9
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BU of 5iz9 by Molmil
Protein-protein interaction
分子名称: ACE-GLY-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein
著者Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J.
登録日2016-03-25
公開日2017-07-05
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
3UDC
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BU of 3udc by Molmil
Crystal structure of a membrane protein
分子名称: Small-conductance mechanosensitive channel, C-terminal peptide from Small-conductance mechanosensitive channel
著者Li, W, Ge, J, Yang, M.
登録日2011-10-28
公開日2012-10-31
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.355 Å)
主引用文献Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance
Proc.Natl.Acad.Sci.USA, 109, 2012
8X3Y
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BU of 8x3y by Molmil
ThDP-dependent HKA synthase
分子名称: ADENOSINE-5'-DIPHOSPHATE, BbmA, MAGNESIUM ION, ...
著者Yu, J.H, Liu, T.
登録日2023-11-14
公開日2024-11-20
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon-carbon linkage reactions.
Nat.Chem., 2025
8X3Z
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BU of 8x3z by Molmil
ThDP-dependent HKA synthase
分子名称: ADENOSINE-5'-DIPHOSPHATE, CsmA, MAGNESIUM ION, ...
著者Yu, J.H, Liu, T.
登録日2023-11-14
公開日2024-11-20
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon-carbon linkage reactions.
Nat.Chem., 2025
8X3X
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BU of 8x3x by Molmil
ThDP-dependent HKA synthase
分子名称: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ADENOSINE-5'-DIPHOSPHATE, BbmA, ...
著者Yu, J.H, Liu, T.
登録日2023-11-14
公開日2024-11-20
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon-carbon linkage reactions.
Nat.Chem., 2025
6MC1
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BU of 6mc1 by Molmil
Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one, ACETATE ION, ...
著者Gannam, Z.T.K, Anderson, K.S, Bennett, A.M, Lolis, E.
登録日2018-08-30
公開日2020-08-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.
Sci.Signal., 13, 2020
8XOD
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BU of 8xod by Molmil
ThDP-dependent HKA synthase
分子名称: 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(~{R})-cyclobutyl(oxidanyl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, ADENOSINE-5'-DIPHOSPHATE, BbmA-G484F complex with CBOA, ...
著者Yu, J.H, Liu, T.
登録日2024-01-01
公開日2025-01-01
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon-carbon linkage reactions.
Nat.Chem., 2025
7LQV
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BU of 7lqv by Molmil
Cryo-EM structure of NTD-directed neutralizing antibody 4-8 Fab in complex with SARS-CoV-2 S2P spike
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-8 Heavy Chain, 4-8 Light chain, ...
著者Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L.
登録日2021-02-15
公開日2021-03-24
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite
Cell Host Microbe, 2021

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件を2025-07-09に公開中

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