2MWS
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1NES
| STRUCTURE OF THE PRODUCT COMPLEX OF ACETYL-ALA-PRO-ALA WITH PORCINE PANCREATIC ELASTASE AT 1.65 ANGSTROMS RESOLUTION | 分子名称: | ACETYL-ALA-PRO-ALA, CALCIUM ION, ELASTASE, ... | 著者 | Meyer Junior, E.F, Radhakrishnan, R, M Cole, G, Presta, L.G. | 登録日 | 1995-07-31 | 公開日 | 1996-01-29 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure of the product complex of acetyl-Ala-Pro-Ala with porcine pancreatic elastase at 1.65 A resolution. J.Mol.Biol., 189, 1986
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3DS6
| P38 complex with a phthalazine inhibitor | 分子名称: | Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide | 著者 | Herberich, B, Syed, R, Li, V, Grosfeld, D. | 登録日 | 2008-07-11 | 公開日 | 2008-10-07 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J.Med.Chem., 51, 2008
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3DT1
| P38 Complexed with a quinazoline inhibitor | 分子名称: | Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide | 著者 | Herberich, B, Syed, R, Li, V, Tasker, A.S. | 登録日 | 2008-07-14 | 公開日 | 2008-10-14 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J.Med.Chem., 51, 2008
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7N8L
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7N8M
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7N8E
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7NRO
| Crystal structure of AlkB in complex with manganese and N-(4-((6-((carboxymethyl)carbamoyl)-5-hydroxypyridin-2-yl)amino)phenyl)-N-oxohydroxylammonium | 分子名称: | 2-[[6-[(4-nitrophenyl)amino]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Alpha-ketoglutarate-dependent dioxygenase AlkB, MANGANESE (II) ION | 著者 | Shishodia, S, Maheswaran, P, Leissing, T, Aik, W.S, McDonough, M.A, Schofield, C.J. | 登録日 | 2021-03-04 | 公開日 | 2021-10-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. J.Med.Chem., 64, 2021
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1ZGK
| 1.35 angstrom structure of the Kelch domain of Keap1 | 分子名称: | Kelch-like ECH-associated protein 1 | 著者 | Li, X, Bottoms, C.A, Hannink, M, Beamer, L.J. | 登録日 | 2005-04-21 | 公開日 | 2005-10-04 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1. Acta Crystallogr.,Sect.D, 61, 2005
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7VZF
| Cryo-EM structure of amyloid fibril formed by full-length human SOD1 | 分子名称: | Superoxide dismutase [Cu-Zn] | 著者 | Wang, L.Q, Ma, Y.Y, Yuan, H.Y, Zhao, K, Zhang, M.Y, Wang, Q, Huang, X, Xu, W.C, Chen, J, Li, D, Zhang, D.L, Zou, L.Y, Yin, P, Liu, C, Liang, Y. | 登録日 | 2021-11-16 | 公開日 | 2022-06-29 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion. Nat Commun, 13, 2022
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8D0A
| Crystal structure of human USP30 in complex with a covalent inhibitor 829 and a Fab | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION, mouse anti-huUSP30 Fab heavy chain, ... | 著者 | Song, X, Butler, J, Li, C, Zhang, K, Zhang, D, Hao, Y. | 登録日 | 2022-05-25 | 公開日 | 2023-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | TBD To Be Published
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5GP0
| Crystal structure of geraniol-NUDX1 complex | 分子名称: | GERANYL DIPHOSPHATE, GLYCEROL, Nudix hydrolase 1 | 著者 | Liu, J, Guan, Z, Zou, T, Yin, P. | 登録日 | 2016-07-30 | 公開日 | 2017-10-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | 主引用文献 | Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis. Mol Plant, 11, 2018
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3EE1
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8ECE
| E. coli L-asparaginase II mutant (V27T) in complex with L-Glu | 分子名称: | 1,2-ETHANEDIOL, GLUTAMIC ACID, L-asparaginase 2 | 著者 | Strzelczyk, P, Wlodawer, A, Lubkowski, J. | 登録日 | 2022-09-01 | 公開日 | 2022-11-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | The E. coli L-asparaginase V27T mutant: structural and functional characterization and comparison with theoretical predictions. Febs Lett., 596, 2022
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8ECD
| E. coli L-asparaginase II mutant (V27T) in complex with L-Asp | 分子名称: | 1,2-ETHANEDIOL, ASPARTIC ACID, CITRIC ACID, ... | 著者 | Strzelczyk, P, Wlodawer, A, Lubkowski, J. | 登録日 | 2022-09-01 | 公開日 | 2022-11-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | The E. coli L-asparaginase V27T mutant: structural and functional characterization and comparison with theoretical predictions. Febs Lett., 596, 2022
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7KDO
| Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-73 | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine | 著者 | Shaw, G.X, Shi, G, Ji, X. | 登録日 | 2020-10-09 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding. Bioorg.Med.Chem., 29, 2021
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7KDR
| Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-75 | 分子名称: | 1,2-ETHANEDIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-{[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]sulfonyl}-5'-deoxyadenosine, ... | 著者 | Shaw, G.X, Shi, G, Ji, X. | 登録日 | 2020-10-09 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.488 Å) | 主引用文献 | Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding. Bioorg.Med.Chem., 29, 2021
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5TX5
| Rip1 Kinase ( flag 1-294, C34A, C127A, C233A, C240A) with GSK772 | 分子名称: | 3-benzyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide, Receptor-interacting serine/threonine-protein kinase 1 | 著者 | Campobasso, N, Ward, P, Thrope, J. | 登録日 | 2016-11-15 | 公開日 | 2017-07-05 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J. Med. Chem., 60, 2017
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6L77
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6J2E
| Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Ebola virus-derived peptide EBOV-NP1 | 分子名称: | Beta-2-microglobulin, EBOV-NP1, MHC class I antigen | 著者 | Lu, D, Liu, K.F, Yue, C, Lu, Q, Cheng, H, Chai, Y, Qi, J.X, Gao, G.F, Liu, W.J. | 登録日 | 2019-01-01 | 公開日 | 2019-09-18 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats. Plos Biol., 17, 2019
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6IX4
| Structure of an epoxide hydrolase from Aspergillus usamii E001 (AuEH2) at 1.51 Angstroms resolution | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Hu, D, Hu, B.C, Hou, X.D, Wu, L, Rao, Y.J, Wu, M.C. | 登録日 | 2018-12-09 | 公開日 | 2019-12-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.511 Å) | 主引用文献 | Nearly perfect kinetic resolution of racemic o-nitrostyrene oxide by AuEH2, a microsomal epoxide hydrolase from Aspergillus usamii, with high enantio- and regio-selectivity. Int.J.Biol.Macromol., 169, 2021
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6J2G
| Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Ebola virus-derived peptide EBOV-NP2 | 分子名称: | Beta-2-microglobulin, EBOV-NP2, Ptal-N*01:01 | 著者 | Lu, D, Liu, K.F, Yue, C, Lu, Q, Cheng, H, Chai, Y, Qi, J.X, Gao, G.F, Liu, W.J. | 登録日 | 2019-01-01 | 公開日 | 2019-09-18 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats. Plos Biol., 17, 2019
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6J2H
| Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 mutant (Met52 Asp53 Leu54 deleted) in complex with Hendra virus-derived peptide HeV1 | 分子名称: | Beta-2-microglobulin, HeV1, Ptal-N*01:01 (Met52 Asp53 Leu54 deleted) | 著者 | Lu, D, Liu, K.F, Yue, C, Lu, Q, Cheng, H, Chai, Y, Qi, J.X, Gao, G.F, Liu, W.J. | 登録日 | 2019-01-01 | 公開日 | 2019-09-18 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats. Plos Biol., 17, 2019
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6J2D
| Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV1 | 分子名称: | HeV1, Ptal-N*01:01, beta-2 microglobulin | 著者 | Lu, D, Liu, K.F, Yue, C, Lu, Q, Cheng, H, Chai, Y, Qi, J.X, Gao, G.F, Liu, W.J. | 登録日 | 2019-01-01 | 公開日 | 2019-09-18 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.313 Å) | 主引用文献 | Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats. Plos Biol., 17, 2019
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6J2F
| Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV2 | 分子名称: | HeV2, Ptal-N*01:01, beta-2 microglobulin | 著者 | Lu, D, Liu, K.F, Yue, C, Lu, Q, Cheng, H, Chai, Y, Qi, J.X, Gao, G.F, Liu, W.J. | 登録日 | 2019-01-01 | 公開日 | 2019-09-18 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats. Plos Biol., 17, 2019
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