7KDO
Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-73
Summary for 7KDO
Entry DOI | 10.2210/pdb7kdo/pdb |
Descriptor | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine (3 entities in total) |
Functional Keywords | alpha beta, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 1 |
Total formula weight | 18639.25 |
Authors | Shaw, G.X.,Shi, G.,Ji, X. (deposition date: 2020-10-09, release date: 2020-12-02, Last modification date: 2023-10-18) |
Primary citation | Shi, G.,Shaw, G.X.,Zhu, F.,Tarasov, S.G.,Ji, X. Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding. Bioorg.Med.Chem., 29:115847-115847, 2021 Cited by PubMed: 33199204DOI: 10.1016/j.bmc.2020.115847 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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