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7KDO

Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-73

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003848molecular_function2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
A0005524molecular_functionATP binding
A0009396biological_processfolic acid-containing compound biosynthetic process
A0016301molecular_functionkinase activity
A0046654biological_processtetrahydrofolate biosynthetic process
A0046656biological_processfolic acid biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues25
Detailsbinding site for residue H73 A 201
ChainResidue
ALYS23
AASP95
AASP97
AILE98
AARG110
ATHR112
AHIS115
ATYR116
AARG121
APHE123
AHIS148
ATHR42
AHOH303
AHOH360
AHOH371
AHOH376
AHOH387
AHOH389
APRO43
ALEU45
ATYR53
AASN55
AGLN74
ATRP89
AGLY90

Functional Information from PROSITE/UniProt
site_idPS00794
Number of Residues12
DetailsHPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDLDIM
ChainResidueDetails
AARG88-MET99

Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 151
ChainResidueDetails
AARG82electrostatic stabiliser, hydrogen bond donor
AARG92electrostatic stabiliser, hydrogen bond donor
AASP95metal ligand
AASP97metal ligand

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PDB entries from 2024-07-31

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