5GZR
 
 | | Zika virus E protein complexed with a neutralizing antibody Z23-Fab | | 分子名称: | Z23 Fab heavy chain, Z23 Fab light chain, structural protein E, ... | | 著者 | Gao, G.G, Shi, Y, Peng, R, Liu, S. | | 登録日 | 2016-10-01 | | 公開日 | 2016-11-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (9.4 Å) | | 主引用文献 | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
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4J3F
 | | Crystal Structure of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold. | | 分子名称: | 1-(4-methoxy-3-methylbenzyl)-5,6,7,8-tetrahydro-1H-naphtho[2,3-d]imidazole, ACETATE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... | | 著者 | Mehboob, S, Boci, T, Brubaker, L, Santarsiero, B.D, Johnson, M.E. | | 登録日 | 2013-02-05 | | 公開日 | 2014-07-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).
Bioorg.Med.Chem.Lett., 25, 2015
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5Y7W
 | | Crystal structure of the Nco-A1 PAS-B domain with YL-2 | | 分子名称: | Nuclear receptor coactivator 1, YL-2 peptide | | 著者 | Lee, Y.J, Yoon, H.S, Lee, J.H, Bae, J.H, Song, J.Y, Lim, H.S. | | 登録日 | 2017-08-18 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction
J. Am. Chem. Soc., 139, 2017
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4J1N
 | | Crystal structures of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold | | 分子名称: | 1-(4-methoxy-3-methylbenzyl)-1,5,6,7-tetrahydroindeno[5,6-d]imidazole, Enoyl-[acyl-carrier-protein] reductase [NADH], GLYCEROL, ... | | 著者 | Mehboob, S, Boci, T, Brubaker, L, Santarsiero, B.D, Johnson, M.E. | | 登録日 | 2013-02-01 | | 公開日 | 2014-07-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).
Bioorg.Med.Chem.Lett., 25, 2015
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4J4T
 | | Crystal Structure of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold | | 分子名称: | 1-(1,3-benzodioxol-5-ylmethyl)-5,6,7,8-tetrahydro-1H-naphtho[2,3-d]imidazole, ACETATE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... | | 著者 | Mehboob, S, Boci, T, Brubaker, L, Santarsiero, B.D, Johnson, M.E. | | 登録日 | 2013-02-07 | | 公開日 | 2014-07-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).
Bioorg.Med.Chem.Lett., 25, 2015
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4JDR
 | | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase from escherichia coli | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Chandrasekhar, K, Arjunan, P, Furey, W. | | 登録日 | 2013-02-25 | | 公開日 | 2013-04-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Insight to the Interaction of the Dihydrolipoamide Acetyltransferase (E2) Core with the Peripheral Components in the Escherichia coli Pyruvate Dehydrogenase Complex via Multifaceted Structural Approaches.
J.Biol.Chem., 288, 2013
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3F3M
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2MK5
 | | Solution structure of a protein domain | | 分子名称: | Endolysin | | 著者 | Feng, Y, Gu, J. | | 登録日 | 2014-01-24 | | 公開日 | 2014-05-28 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and biochemical characterization reveals LysGH15 as an unprecedented "EF-hand-like" calcium-binding phage lysin.
Plos Pathog., 10, 2014
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2ANR
 | | Crystal structure (II) of Nova-1 KH1/KH2 domain tandem with 25nt RNA hairpin | | 分子名称: | 5'-R(*CP*(5BU)P*CP*GP*CP*GP*GP*AP*UP*CP*AP*GP*UP*CP*AP*CP*CP*CP*AP*AP*GP*CP*GP*AP*G)-3', MAGNESIUM ION, POTASSIUM ION, ... | | 著者 | Malinina, L, Teplova, M, Musunuru, K, Teplov, A, Darnell, J.C, Burley, S.K, Darnell, R.B, Patel, D.J. | | 登録日 | 2005-08-11 | | 公開日 | 2006-10-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.
Structure, 19, 2011
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2ANN
 | | Crystal structure (I) of Nova-1 KH1/KH2 domain tandem with 25 nt RNA hairpin | | 分子名称: | 5'-R(*CP*GP*CP*GP*CP*GP*GP*AP*UP*CP*AP*GP*UP*CP*AP*CP*CP*CP*AP*AP*GP*CP*GP*CP*G)-3', MAGNESIUM ION, POTASSIUM ION, ... | | 著者 | Malinina, L, Teplova, M, Musunuru, K, Teplov, A, Darnell, J.C, Burley, S.K, Darnell, R.B, Patel, D.J. | | 登録日 | 2005-08-11 | | 公開日 | 2006-10-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.
Structure, 19, 2011
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5YSX
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5GV5
 | | Crystal structure of Candida antarctica Lipase B with active Ser105 modified with a phosphonate inhibitor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lipase B, ... | | 著者 | Park, S.Y, Lee, H. | | 登録日 | 2016-09-02 | | 公開日 | 2017-09-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Structural and Experimental Evidence for the Enantiomeric Recognition toward a Bulky sec-Alcohol by Candida antarctica Lipase B
Acs Catalysis, 6, 2016
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3LPY
 | | Crystal structure of the RRM domain of CyP33 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Peptidyl-prolyl cis-trans isomerase E, SULFATE ION | | 著者 | Wang, Z, Patel, D.J. | | 登録日 | 2010-02-07 | | 公開日 | 2010-07-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
Cell(Cambridge,Mass.), 141, 2010
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3LQH
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3LQJ
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3LQI
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2MBE
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7XUR
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7BPK
 | | Zika virus envelope protein mutant bound to mAb | | 分子名称: | Envelope protein, IG c307_light_IGLV1-51_IGLJ2, Z3L1 Heavy chain | | 著者 | Dai, L, Qi, J, Gao, G.F. | | 登録日 | 2020-03-23 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch.
Nat.Immunol., 22, 2021
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7BQ5
 | | ZIKV sE bound to mAb Z6 | | 分子名称: | Z6 Light Chain, Z6 heavy chain, envelope protein | | 著者 | Dai, L, Qi, J, Gao, G.F. | | 登録日 | 2020-03-24 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch.
Nat.Immunol., 22, 2021
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4A4D
 | | Crystal structure of the N-terminal domain of the Human DEAD-BOX RNA helicase DDX5 (P68) | | 分子名称: | PROBABLE ATP-DEPENDENT RNA HELICASE DDX5 | | 著者 | Dutta, S, Choi, Y.W, Kotaka, M, Fielding, B.C, Tan, Y.J. | | 登録日 | 2011-10-11 | | 公開日 | 2012-08-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The Variable N-Terminal Region of Ddx5 Contains Structural Elements and Auto-Inhibits its Interaction with Ns5B of Hepatitis C Virus.
Biochem.J., 446, 2012
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6IEC
 | | Structure of RVFV Gn and human monoclonal antibody R17 | | 分子名称: | NSmGnGc, R17 H chain, R17 L chain | | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | | 登録日 | 2018-09-13 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
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6IEA
 | | Structure of RVFV Gn and human monoclonal antibody R13 | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, NSmGnGc, ... | | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | | 登録日 | 2018-09-13 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
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6IW2
 | | Crystal structure of 5A ScFv in complex with YFV-17D sE in prefusion state | | 分子名称: | Envelope protein E, Heavy chain of monoclonal antibody 5A, Light chain of monoclonal antibody 5A | | 著者 | Lu, X.S, Xiao, H.X, Li, S.H, Pang, X.F. | | 登録日 | 2018-12-04 | | 公開日 | 2019-02-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.
Cell Rep, 26, 2019
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6IEK
 | | Structure of RVFV Gn and human monoclonal antibody R12 | | 分子名称: | Heavy chain of Fab R12, Light chain of Fab R12, NSmGnGc | | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | | 登録日 | 2018-09-14 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
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