7RHR
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![BU of 7rhr by Molmil](/molmil-images/mine/7rhr) | Cryo-EM structure of Xenopus Patched-1 in nanodisc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Huang, P, Lian, T, Jiang, J, Salic, A. | 登録日 | 2021-07-18 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex. Dev.Cell, 57, 2022
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6GDZ
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![BU of 6gdz by Molmil](/molmil-images/mine/6gdz) | exendin-4 based dual GLP-1/glucagon receptor agonist | 分子名称: | (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid, Exendin-4 | 著者 | Evers, A, Kurz, M. | 登録日 | 2018-04-25 | 公開日 | 2018-06-20 | 最終更新日 | 2019-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations. J. Med. Chem., 61, 2018
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6GE2
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![BU of 6ge2 by Molmil](/molmil-images/mine/6ge2) | exendin-4 based dual GLP-1/glucagon receptor agonist | 分子名称: | (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid, Exendin-4 | 著者 | Evers, A, Kurz, M. | 登録日 | 2018-04-25 | 公開日 | 2018-06-20 | 最終更新日 | 2019-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations. J. Med. Chem., 61, 2018
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6GB1
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8QDY
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3TTJ
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![BU of 3ttj by Molmil](/molmil-images/mine/3ttj) | Crystal Structure of JNK3 complexed with CC-359, a JNK inhibitor for the prevention of ischemia-reperfusion injury | 分子名称: | 9-cyclopentyl-N~8~-(2-fluorophenyl)-N~2~-(4-methoxyphenyl)-9H-purine-2,8-diamine, Mitogen-activated protein kinase 10 | 著者 | Plantevin-Krenitsky, V, Delgado, M, Nadolny, L, Sahasrabudhe, K, Ayala, S, Clareen, S, Hilgraf, R, Albers, R, Kois, A, Hughes, K, Wright, J, Nowakowski, J, Sudbeck, E, Ghosh, S, Bahmanyar, S, Chamberlain, P, Muir, J, Cathers, B.E, Giegel, D, Xu, L, Celeridad, M, Moghaddam, M, Khatsenko, O, Omholt, P, Katz, J, Pai, S, Fan, R, Tang, Y, Shirley, M.A, Benish, B, Blease, K, Raymon, H, Bhagwat, S, Bennett, B, Satoh, Y. | 登録日 | 2011-09-14 | 公開日 | 2012-01-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury. Bioorg.Med.Chem.Lett., 22, 2012
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8QE0
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8QE2
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8QE3
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8QE1
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8QDZ
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7K9P
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![BU of 7k9p by Molmil](/molmil-images/mine/7k9p) | Room temperature structure of NSP15 Endoribonuclease from SARS CoV-2 solved using SFX. | 分子名称: | CITRIC ACID, Uridylate-specific endoribonuclease | 著者 | Botha, S, Jernigan, R, Chen, J, Coleman, M.A, Frank, M, Grant, T.D, Hansen, D.T, Ketawala, G, Logeswaran, D, Martin-Garcia, J, Nagaratnam, N, Raj, A.L.L.X, Shelby, M, Yang, J.-H, Yung, M.C, Fromme, P. | 登録日 | 2020-09-29 | 公開日 | 2020-10-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser. Structure, 2022
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7OO5
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3TTI
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![BU of 3tti by Molmil](/molmil-images/mine/3tti) | Crystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor | 分子名称: | GLYCEROL, Mitogen-activated protein kinase 10, trans-4-({9-[(3S)-tetrahydrofuran-3-yl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl}amino)cyclohexanol | 著者 | Plantevin-Krenitsky, V, Nadolny, L, Delgado, M, Ayala, L, Clareen, S, Hilgraf, R, Albers, R, Hegde, S, D'Sidocky, N, Sapienza, J, Wright, J, McCarrick, M, Bahmanyar, S, Chamberlain, P, Delker, S.L, Muir, J, Giegel, D, Xu, L, Celeridad, M, Lachowitzer, J, Bennett, B, Moghaddam, M, Khatsenko, O, Katz, J, Fan, R, Bai, A, Tang, Y, Shirley, M.A, Benish, B, Bodine, T, Blease, K, Raymon, H, Cathers, B.E, Satoh, Y. | 登録日 | 2011-09-14 | 公開日 | 2012-02-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorg.Med.Chem.Lett., 22, 2012
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6ET4
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![BU of 6et4 by Molmil](/molmil-images/mine/6et4) | HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR | 分子名称: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ACETIC ACID, CHLORIDE ION, ... | 著者 | Hakansson, M, Walse, B, Gustavsson, A.-L, Lain, S. | 登録日 | 2017-10-25 | 公開日 | 2018-03-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. Nat Commun, 9, 2018
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7NYJ
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![BU of 7nyj by Molmil](/molmil-images/mine/7nyj) | Structure of OBP1 from Varroa destructor, form P3<2>21 | 分子名称: | CALCIUM ION, Odorant Binding Protein 1 from Varoa destructor, form P3<2>21, ... | 著者 | Cambillau, C, Amigues, B, Roussel, A, Leone, P, Gaubert, A, Pelosi, P. | 登録日 | 2021-03-22 | 公開日 | 2021-07-07 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | A new non-classical fold of varroa odorant-binding proteins reveals a wide open internal cavity. Sci Rep, 11, 2021
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7NZA
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![BU of 7nza by Molmil](/molmil-images/mine/7nza) | Structure of OBP1 from Varroa destructor, form P2<1> | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Odorant Binding Protein from Varroa destructor, form P2<1>, ... | 著者 | Cambillau, C, Amigues, B, Roussel, A, Leone, P, Gaubert, A, Pelosi, P. | 登録日 | 2021-03-23 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.199 Å) | 主引用文献 | A new non-classical fold of varroa odorant-binding proteins reveals a wide open internal cavity. Sci Rep, 11, 2021
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3V77
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![BU of 3v77 by Molmil](/molmil-images/mine/3v77) | Crystal structure of a putative fumarylacetoacetate isomerase/hydrolase from Oleispira antarctica | 分子名称: | ACETATE ION, D(-)-TARTARIC ACID, Putative fumarylacetoacetate isomerase/hydrolase, ... | 著者 | Stogios, P.J, Kagan, O, Di Leo, R, Bochkarev, A, Edwards, A.M, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2011-12-20 | 公開日 | 2012-01-18 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica. Nat Commun, 4, 2013
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8D91
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8D8Z
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8D8W
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![BU of 8d8w by Molmil](/molmil-images/mine/8d8w) | Crystal structure of ChoE with Ser38 adopting alternative conformations | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ChoE, IODIDE ION | 著者 | Pham, V.D, Shi, R. | 登録日 | 2022-06-09 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal structures of bacterial acetylcholinesterase ChoE provide insights into the plasticity of catalytic Ser in regulating the active site geometry and the functional state of the SGNH hydrolases To be published
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8D8Y
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![BU of 8d8y by Molmil](/molmil-images/mine/8d8y) | Crystal structure of ChoE N147A mutant in complex with acetylthiocholine | 分子名称: | 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, ACETYLTHIOCHOLINE, CHLORIDE ION, ... | 著者 | Pham, V.D, Shi, R. | 登録日 | 2022-06-09 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Crystal structures of bacterial acetylcholinesterase ChoE provide insights into the plasticity of catalytic Ser in regulating the active site geometry and the functional state of the SGNH hydrolases To be published
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8D90
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8D8X
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8B7Y
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![BU of 8b7y by Molmil](/molmil-images/mine/8b7y) | Cryo-EM structure of the E.coli 70S ribosome in complex with the antibiotic Myxovalargin B. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Koller, T.O, Graf, M, Wilson, D.N. | 登録日 | 2022-10-03 | 公開日 | 2023-01-25 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition. J.Am.Chem.Soc., 145, 2023
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