6GB1

Crystal structure of the GLP1 receptor ECD with Peptide 11

Summary for 6GB1

• Entry DOI: 10.2210/pdb6gb1/pdb
• Descriptor: Glucagon-like peptide 1 receptor, Peptide 11, SULFATE ION, ... (5 entities in total)
• Functional Keywords: glucagon-like peptide 1 protein-peptide complex incretins diabetes drug discovery, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 18505.53

Authors

Schreuder, H.A.,Liesum, A. (deposition date: 2018-04-13, release date: 2018-06-20, Last modification date: 2024-01-17)

• Primary citation: Evers, A.,Bossart, M.,Pfeiffer-Marek, S.,Elvert, R.,Schreuder, H.,Kurz, M.,Stengelin, S.,Lorenz, M.,Herling, A.,Konkar, A.,Lukasczyk, U.,Pfenninger, A.,Lorenz, K.,Haack, T.,Kadereit, D.,Wagner, M.; Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.; J. Med. Chem., 61:5580-5593, 2018; PubMed: 29879354; DOI: 10.1021/acs.jmedchem.8b00292

Experimental method

X-RAY DIFFRACTION (2.73 Å)