7E56
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7E3O
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7F5B
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![BU of 7f5b by Molmil](/molmil-images/mine/7f5b) | LBD-TMD focused reconstruction of DNQX-bound GluK2-1xNeto2 complex | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F5A
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![BU of 7f5a by Molmil](/molmil-images/mine/7f5a) | DNQX-bound GluK2-2xNeto2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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8K8H
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7E34
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![BU of 7e34 by Molmil](/molmil-images/mine/7e34) | Crystal structure of SUN1-Speedy A-CDK2 | 分子名称: | Cyclin-dependent kinase 2, GLYCEROL, SUN domain-containing protein 1, ... | 著者 | Chen, Y, Huang, C, Wu, J, Lei, M. | 登録日 | 2021-02-08 | 公開日 | 2021-04-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | The SUN1-SPDYA interaction plays an essential role in meiosis prophase I. Nat Commun, 12, 2021
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8KCI
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![BU of 8kci by Molmil](/molmil-images/mine/8kci) | ATP-bound hMRP5 outward-open | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 5, MAGNESIUM ION | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-08-07 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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2HFP
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![BU of 2hfp by Molmil](/molmil-images/mine/2hfp) | Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands | 分子名称: | 3-(4-METHOXYPHENYL)-N-(PHENYLSULFONYL)-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2-CARBOXAMIDE, Peroxisome proliferator-activated receptor gamma, SRC Peptide Fragment | 著者 | Pokross, M.E, Evdokimov, A.G, Walter, R.L, Mekel, M.J, Hopkins, C.R. | 登録日 | 2006-06-25 | 公開日 | 2006-09-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. Bioorg.Med.Chem.Lett., 16, 2006
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7F59
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![BU of 7f59 by Molmil](/molmil-images/mine/7f59) | DNQX-bound GluK2-1xNeto2 complex | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F56
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![BU of 7f56 by Molmil](/molmil-images/mine/7f56) | DNQX-bound GluK2-1xNeto2 complex, with asymmetric LBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F57
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![BU of 7f57 by Molmil](/molmil-images/mine/7f57) | Kainate-bound GluK2-1xNeto2 complex, at the desensitized state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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2JYJ
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![BU of 2jyj by Molmil](/molmil-images/mine/2jyj) | Re-refining the tetraloop-receptor RNA-RNA complex using NMR-derived restraints and Xplor-nih (2.18) | 分子名称: | RNA (43-MER) | 著者 | Zuo, X, Wang, J, Foster, T.R, Schwieters, C.D, Tiede, D.M, Butcher, S.E, Wang, Y. | 登録日 | 2007-12-13 | 公開日 | 2008-10-07 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | RNA helical packing in solution: NMR structure of a 30 kDa GAAA tetraloop-receptor complex. J.Mol.Biol., 351, 2005
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1HZI
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![BU of 1hzi by Molmil](/molmil-images/mine/1hzi) | INTERLEUKIN-4 MUTANT E9A | 分子名称: | INTERLEUKIN-4, SULFATE ION | 著者 | Hulsmeyer, M, Scheufler, C, Dreyer, M.K. | 登録日 | 2001-01-25 | 公開日 | 2001-08-29 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation. Acta Crystallogr.,Sect.D, 57, 2001
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8TDQ
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![BU of 8tdq by Molmil](/molmil-images/mine/8tdq) | SFX-XFEL structure of CYP121 cocrystallized with substrate cYY | 分子名称: | (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Nguyen, R.C, Dasgupta, M, Bhowmick, A, Kern, J.F, Liu, A. | 登録日 | 2023-07-04 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121. J.Am.Chem.Soc., 145, 2023
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8TDP
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![BU of 8tdp by Molmil](/molmil-images/mine/8tdp) | Time-resolved SFX-XFEL crystal structure of CYP121 bound with cYY reacted with peracetic acid for 200 milliseconds | 分子名称: | (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, HYDROGEN PEROXIDE, Mycocyclosin synthase, ... | 著者 | Nguyen, R.C, Dasgupta, M, Bhowmick, A, Kern, J.F, Liu, A. | 登録日 | 2023-07-04 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121. J.Am.Chem.Soc., 145, 2023
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7VUP
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7VUQ
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6KZI
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![BU of 6kzi by Molmil](/molmil-images/mine/6kzi) | Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine derivatives | 分子名称: | 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, Serine/threonine-protein kinase pim-1 | 著者 | Zhang, W, Wan, X, Li, W, Xie, Y, Huang, N. | 登録日 | 2019-09-24 | 公開日 | 2020-03-04 | 最終更新日 | 2021-03-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
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8U1F
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![BU of 8u1f by Molmil](/molmil-images/mine/8u1f) | FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10 | 分子名称: | Fibroblast growth factor receptor 2, GLYCEROL, N-[4-(4-amino-7-methyl-5-{4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylpropanamide, ... | 著者 | Valverde, R, Foster, L. | 登録日 | 2023-08-31 | 公開日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proc.Natl.Acad.Sci.USA, 121, 2024
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7VJL
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![BU of 7vjl by Molmil](/molmil-images/mine/7vjl) | The crystal structure of FGFR4 kinase domain in complex with N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(2,2,2-trifluoroacetyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide | 分子名称: | Fibroblast growth factor receptor 4, N-[5-(aminomethyl)-4-(2-methoxyethylamino)pyridin-2-yl]-7-[2,2,2-tris(fluoranyl)ethanoyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide | 著者 | Zhang, Z.M, Wang, Y.J. | 登録日 | 2021-09-28 | 公開日 | 2022-02-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.900173 Å) | 主引用文献 | Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design. Bioorg.Med.Chem., 50, 2021
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7W7L
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8JFG
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8JFN
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8JFM
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8JFJ
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