3RV9
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![BU of 3rv9 by Molmil](/molmil-images/mine/3rv9) | Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Ethyl R-Group | 分子名称: | 3-{[(1Z)-1-carboxybut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI | 著者 | Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-05-06 | 公開日 | 2012-05-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 51, 2012
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3RV8
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![BU of 3rv8 by Molmil](/molmil-images/mine/3rv8) | Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group | 分子名称: | 3-{[(E)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI | 著者 | Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-05-06 | 公開日 | 2012-05-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 51, 2012
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3RV6
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![BU of 3rv6 by Molmil](/molmil-images/mine/3rv6) | Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Phenyl R-Group | 分子名称: | 3-{[(E)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ... | 著者 | Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-05-06 | 公開日 | 2012-05-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 51, 2012
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3RV7
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![BU of 3rv7 by Molmil](/molmil-images/mine/3rv7) | Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Isopropyl R-Group | 分子名称: | 3-{[(1Z)-1-carboxy-3-methylbut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI | 著者 | Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-05-06 | 公開日 | 2012-05-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 51, 2012
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3ST6
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![BU of 3st6 by Molmil](/molmil-images/mine/3st6) | Structure of a M. tuberculosis Synthase, MbtI, in Complex with an Isochorismate Analogue Inhibitor | 分子名称: | 3-[(1-carboxyethenyl)oxy]-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI | 著者 | Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-07-08 | 公開日 | 2012-05-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 51, 2012
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3Q0J
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![BU of 3q0j by Molmil](/molmil-images/mine/3q0j) | |
3PZK
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![BU of 3pzk by Molmil](/molmil-images/mine/3pzk) | |
3QJ7
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![BU of 3qj7 by Molmil](/molmil-images/mine/3qj7) | Crystal Structure of the Mycobacterium tuberculosis Thymidylate synthase (ThyA) bound to dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, SPERMINE, Thymidylate synthase | 著者 | Reddy, M.C.M, Bruning, J.B, Harshbarger, W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-01-28 | 公開日 | 2011-06-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.504 Å) | 主引用文献 | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: insights into the selectivity and mode of inhibition To be Published
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3QR9
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3QS8
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![BU of 3qs8 by Molmil](/molmil-images/mine/3qs8) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS174) | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-benzylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | 著者 | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-02-20 | 公開日 | 2012-08-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3QJA
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3QQS
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![BU of 3qqs by Molmil](/molmil-images/mine/3qqs) | Anthranilate phosphoribosyltransferase (TRPD) from Mycobacterium tuberculosis (complex with inhibitor ACS172) | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2,2'-iminodibenzoic acid, Anthranilate phosphoribosyltransferase, ... | 著者 | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-02-16 | 公開日 | 2012-08-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3R6C
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![BU of 3r6c by Molmil](/molmil-images/mine/3r6c) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS179) | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 8-methoxyphenanthro[3,4-d][1,3]dioxole-5,6-dicarboxylic acid, Anthranilate phosphoribosyltransferase, ... | 著者 | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-03-21 | 公開日 | 2012-09-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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2I6U
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![BU of 2i6u by Molmil](/molmil-images/mine/2i6u) | Crystal Structure of Ornithine Carbamoyltransferase complexed with Carbamoyl Phosphate and L-Norvaline from Mycobacterium tuberculosis (Rv1656) at 2.2 A | 分子名称: | NORVALINE, Ornithine carbamoyltransferase, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER, ... | 著者 | Sankaranarayanan, R, Moradian, F, Cherney, L.T, Garen, C, Cherney, M.M, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2006-08-29 | 公開日 | 2007-06-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism J.Mol.Biol., 375, 2008
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2FSX
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![BU of 2fsx by Molmil](/molmil-images/mine/2fsx) | Crystal structure of Rv0390 from M. tuberculosis | 分子名称: | BROMIDE ION, COG0607: Rhodanese-related sulfurtransferase, SULFATE ION | 著者 | Bursey, E.H, Radhakannan, T, Yu, M, Segelke, B.W, Lekin, T, Toppani, D, Chang, Y.-B, Kaviratne, T, Woodruff, T, Terwilliger, T.C, Hung, L.-W, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2006-01-23 | 公開日 | 2006-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structure of Rv0390 from Mycobacterium tuberculosis To be Published
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2JEK
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![BU of 2jek by Molmil](/molmil-images/mine/2jek) | Crystal structure of the conserved hypothetical protein Rv1873 from Mycobacterium tuberculosis at 1.38 A | 分子名称: | GLYCEROL, RV1873, SULFATE ION | 著者 | Garen, C.R, Cherney, M.M, Bergmann, E.M, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2007-01-17 | 公開日 | 2007-01-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | The Molecular Structure of Rv1873, a Conserved Hypothetical Protein from Mycobacterium Tuberculosis, at 1.38A Resolution Acta Crystallogr.,Sect.F, 62, 2006
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2IB0
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![BU of 2ib0 by Molmil](/molmil-images/mine/2ib0) | Crystal structure of a conserved hypothetical protein, rv2844, from Mycobacterium tuberculosis | 分子名称: | CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN | 著者 | Yu, M, Bursey, E.H, Radhakannan, T, Kim, C.Y, Kaviratne, T, Woodruff, T, Segelke, B.W, Lekin, T, Toppani, D, Terwilliger, T.C, Hung, L.W, TB Structural Genomics Consortium (TBSGC), Integrated Center for Structure and Function Innovation (ISFI) | 登録日 | 2006-09-08 | 公開日 | 2006-09-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a conserved hypothetical protein, rv2844, from Mycobacterium tuberculosis To be Published
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3QB9
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2I3G
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![BU of 2i3g by Molmil](/molmil-images/mine/2i3g) | Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis in complex with NADP+. | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-acetyl-gamma-glutamyl-phosphate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Cherney, L.T, Cherney, M.M, Garen, C.R, Moraidin, F, James, M.N.G, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB), TB Structural Genomics Consortium (TBSGC) | 登録日 | 2006-08-18 | 公開日 | 2006-09-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal Structure of N-acetyl-gamma-glutamyl-phosphate Reductase from Mycobacterium tuberculosis in Complex with NADP(+). J.Mol.Biol., 367, 2007
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2FR2
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2FGG
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![BU of 2fgg by Molmil](/molmil-images/mine/2fgg) | Crystal Structure of Rv2632c | 分子名称: | Hypothetical protein Rv2632c/MT2708 | 著者 | Yu, M, Bursey, E.H, Radhakannan, T, Segelke, B.W, Lekin, T, Toppani, D, Kim, C.Y, Kaviratne, T, Woodruff, T, Terwilliger, T.C, Hung, L.W, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2005-12-21 | 公開日 | 2006-02-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of Rv2632c To be Published
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2GP6
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2GDN
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2G5F
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![BU of 2g5f by Molmil](/molmil-images/mine/2g5f) | The structure of MbtI from Mycobacterium Tuberculosis, the first enzyme in the synthesis of Mycobactin, reveals it to be a salicylate synthase | 分子名称: | COG0147: Anthranilate/para-aminobenzoate synthases component I, GLYCEROL, IMIDAZOLE, ... | 著者 | Harrison, A.J, Lott, J.S, Yu, M, Ramsay, R, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2006-02-22 | 公開日 | 2006-09-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The Structure of MbtI from Mycobacterium tuberculosis, the First Enzyme in the Biosynthesis of the Siderophore Mycobactin, Reveals It To Be a Salicylate Synthase J.Bacteriol., 188, 2006
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3Q7U
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![BU of 3q7u by Molmil](/molmil-images/mine/3q7u) | Structure of Mtb 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) complexed with CTP | 分子名称: | 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Reddy, M.C.M, Bruning, J.B, Thurman, C, Ioerger, T.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-01-05 | 公開日 | 2011-05-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): a candidate antitubercular drug target Proteins, 2011
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