8W4T
| Crystal structure of PDE5A in complex with a novel inhibitor | 分子名称: | 2-[bis(2-hydroxyethyl)amino]-6-[(4-methoxyphenyl)methylamino]-9-propan-2-yl-7~{H}-purin-8-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Liu, J.Y, Li, M.J, Xu, Y.C. | 登録日 | 2023-08-24 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | 主引用文献 | Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem., 262, 2023
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8IP4
| Cryo-EM structure of hMRS-highEDTA | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | 著者 | Li, M, Li, Y, Yang, X, Shen, Y.Q. | 登録日 | 2023-03-14 | 公開日 | 2023-06-14 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel. Nat Commun, 14, 2023
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8IP5
| Cryo-EM structure of hMRS2-lowEDTA | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | 著者 | Li, M, Li, Y, Yang, X, Shen, Y.Q. | 登録日 | 2023-03-14 | 公開日 | 2023-06-14 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel. Nat Commun, 14, 2023
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8WKP
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3QE7
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7BEF
| Structures of class II bacterial transcription complexes | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Hao, M, Ye, F.Z, Zhang, X.D. | 登録日 | 2020-12-23 | 公開日 | 2021-12-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation. Adv Sci, 9, 2022
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5ZBG
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5YX9
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1ZA7
| The crystal structure of salt stable cowpea cholorotic mottle virus at 2.7 angstroms resolution. | 分子名称: | Coat protein | 著者 | Bothner, B, Speir, J.A, Qu, C, Willits, D.A, Young, M.J, Johnson, J.E. | 登録日 | 2005-04-05 | 公開日 | 2006-03-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Enhanced local symmetry interactions globally stabilize a mutant virus capsid that maintains infectivity and capsid dynamics. J.Virol., 80, 2006
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3UI7
| Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia | 分子名称: | 6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, ZINC ION, ... | 著者 | Yang, S, Smotryski, J, Mcelroy, W, Ho, G, Tulshian, D, Greenlee, W.J, Hodgson, R, Xiao, L, Hruza, A. | 登録日 | 2011-11-04 | 公開日 | 2011-12-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia. Bioorg.Med.Chem.Lett., 22, 2012
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6K9O
| Crystal Structure Analysis of Protein | 分子名称: | Endo-1,4-beta-xylanase 2, GLYCEROL, IODIDE ION | 著者 | Li, C, Wan, Q. | 登録日 | 2019-06-17 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | Studying the Role of a Single Mutation of a Family 11 Glycoside Hydrolase Using High-Resolution X-ray Crystallography. Protein J., 39, 2020
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4FYO
| Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1-[7-(3,4-Dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-pyrrolidin-3-yl}-terephthalamic acid | 分子名称: | 4-{[(3S)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid, Tyrosine-protein kinase SYK | 著者 | Kuglstatter, A, Slade, M. | 登録日 | 2012-07-05 | 公開日 | 2013-01-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Rational design of highly selective spleen tyrosine kinase inhibitors. J.Med.Chem., 55, 2012
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4FZ6
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4P83
| Structure of engineered PyrR protein (PURPLE PyrR) | 分子名称: | Engineered PyrR protein (Purple), URIDINE-5'-MONOPHOSPHATE | 著者 | Perica, T, Kondo, Y, Tiwari, S, McLaughlin, S, Steward, A, Reuter, N, Clarke, J, Teichmann, S.A. | 登録日 | 2014-03-30 | 公開日 | 2014-12-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science, 346, 2014
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4FYN
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4P86
| Structure of PyrR protein from Bacillus subtilis with GMP | 分子名称: | Bifunctional protein PyrR, GLYCEROL, GUANOSINE-5'-MONOPHOSPHATE | 著者 | Perica, T, Kondo, Y, Tiwari, S, McLaughlin, S, Steward, A, Reuter, N, Clarke, J, Teichmann, S.A. | 登録日 | 2014-03-30 | 公開日 | 2014-12-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science, 346, 2014
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7VY6
| Coxsackievirus B3(VP3-234N) incubate with CD55 at pH7.4 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Wang, Q.L, Liu, C.C. | 登録日 | 2021-11-13 | 公開日 | 2022-01-19 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Molecular basis of differential receptor usage for naturally occurring CD55-binding and -nonbinding coxsackievirus B3 strains. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VY5
| Coxsackievirus B3 (VP3-234Q) incubation with CD55 at pH7.4 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Wang, Q.L, Liu, C.C. | 登録日 | 2021-11-13 | 公開日 | 2022-01-19 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Molecular basis of differential receptor usage for naturally occurring CD55-binding and -nonbinding coxsackievirus B3 strains. Proc.Natl.Acad.Sci.USA, 119, 2022
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7W17
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7W14
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7VYL
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7VYK
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7VYM
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4GQ9
| Chikungunya virus neutralizing antibody 9.8B Fab fragment | 分子名称: | Chikungunya virus neutralizing antibody 9.8B Fab fragment heavy chain, Chikungunya virus neutralizing antibody 9.8B Fab fragment light chain | 著者 | Sun, S, Rossmann, M.G. | 登録日 | 2012-08-22 | 公開日 | 2013-07-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.995 Å) | 主引用文献 | Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization. Elife, 2, 2013
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4MGU
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