6J2Q
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![BU of 6j2q by Molmil](/molmil-images/mine/6j2q) | Yeast proteasome in Ub-accepted state (C1-b) | 分子名称: | 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... | 著者 | Cong, Y. | 登録日 | 2019-01-02 | 公開日 | 2019-03-13 | 最終更新日 | 2019-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations. Mol. Cell, 73, 2019
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6N0P
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![BU of 6n0p by Molmil](/molmil-images/mine/6n0p) | |
3B82
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2ZEB
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![BU of 2zeb by Molmil](/molmil-images/mine/2zeb) | Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase | 分子名称: | 1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine, Tryptase beta 2 | 著者 | Spurlino, J.C, Lewandowski, F, Milligan, C. | 登録日 | 2007-12-08 | 公開日 | 2008-12-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives Bioorg.Med.Chem.Lett., 18, 2008
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6M2W
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![BU of 6m2w by Molmil](/molmil-images/mine/6m2w) | Structure of RyR1 (Ca2+/Caffeine/ATP/CaM1234/CHL) | 分子名称: | 5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, ... | 著者 | Ma, R, Haji-Ghassemi, O, Ma, D, Lin, L, Samurkas, A, Van Petegem, F, Yuchi, Z. | 登録日 | 2020-03-01 | 公開日 | 2020-09-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis for diamide modulation of ryanodine receptor. Nat.Chem.Biol., 16, 2020
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3B78
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7DWC
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6N0Q
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![BU of 6n0q by Molmil](/molmil-images/mine/6n0q) | BRAF in complex with N-(4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)phenyl)-3-(trifluoromethyl)benzamide. | 分子名称: | N-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide, Serine/threonine-protein kinase B-raf | 著者 | Mamo, M, Appleton, B.A. | 登録日 | 2018-11-07 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Design and Discovery ofN-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic. J.Med.Chem., 63, 2020
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6KBD
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![BU of 6kbd by Molmil](/molmil-images/mine/6kbd) | fused To-MtbCsm1 with 2dATP | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A),CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), MAGNESIUM ION | 著者 | Li, T, Huo, Y, Jiang, T. | 登録日 | 2019-06-24 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Mycobacterium tuberculosis CRISPR/Cas system Csm1 holds clues to the evolutionary relationship between DNA polymerase and cyclase activity. Int.J.Biol.Macromol., 170, 2020
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3R0Y
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![BU of 3r0y by Molmil](/molmil-images/mine/3r0y) | Crystal Structures of Multidrug-resistant HIV-1 Protease in Complex with Mechanism-Based Aspartyl Protease Inhibitors | 分子名称: | Multidrug-resistant clinical isolate 769 HIV-1 Protease, N-[(2S)-1-{[(2S,3S)-3-hydroxy-5-oxo-5-{[(2R)-1-oxo-3-phenyl-1-(prop-2-yn-1-ylamino)propan-2-yl]amino}-1-phenylpentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]pyridine-2-carboxamide | 著者 | Yedidi, R.S, Gupta, D, Liu, Z, Brunzelle, J, Kovari, I.A, Woster, P.M, Kovari, L.C. | 登録日 | 2011-03-09 | 公開日 | 2012-04-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds. Biochem.Biophys.Res.Commun., 421, 2012
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3CLL
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![BU of 3cll by Molmil](/molmil-images/mine/3cll) | Crystal structure of the Spinach Aquaporin SoPIP2;1 S115E mutant | 分子名称: | Aquaporin | 著者 | Nyblom, M, Alfredsson, A, Hallgren, K, Hedfalk, K, Neutze, R, Trnroth-Horsefield, S. | 登録日 | 2008-03-19 | 公開日 | 2009-02-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and functional analysis of SoPIP2;1 mutants adds insight into plant aquaporin gating. J.Mol.Biol., 387, 2009
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3CN6
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![BU of 3cn6 by Molmil](/molmil-images/mine/3cn6) | Crystal structure of the Spinach Aquaporin SoPIP2;1 S274E mutant | 分子名称: | Aquaporin, CADMIUM ION | 著者 | Nyblom, M, Alfredsson, A, Hallgren, K, Hedfalk, K, Neutze, R, Tornroth-Horsefield, S. | 登録日 | 2008-03-25 | 公開日 | 2009-02-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural and functional analysis of SoPIP2;1 mutants adds insight into plant aquaporin gating. J.Mol.Biol., 387, 2009
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3CN5
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![BU of 3cn5 by Molmil](/molmil-images/mine/3cn5) | Crystal structure of the Spinach Aquaporin SoPIP2;1 S115E, S274E mutant | 分子名称: | Aquaporin | 著者 | Nyblom, M, Alfredsson, A, Hallgren, K, Hedfalk, K, Neutze, R, Tornroth-Horsefield, S. | 登録日 | 2008-03-25 | 公開日 | 2009-02-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural and functional analysis of SoPIP2;1 mutants adds insight into plant aquaporin gating. J.Mol.Biol., 387, 2009
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3QBY
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![BU of 3qby by Molmil](/molmil-images/mine/3qby) | Crystal structure of the PWWP domain of human Hepatoma-derived growth factor 2 | 分子名称: | H4K20me3 Histone H4 Peptide, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | 著者 | Zeng, H, Tempel, W, Amaya, M.F, Adams-Cioaba, M.A, Mackenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-01-14 | 公開日 | 2011-02-09 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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3QJ6
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![BU of 3qj6 by Molmil](/molmil-images/mine/3qj6) | The crystal structure of PWWP domain of human Hepatoma-derived growth factor 2 in complex with H3K79me3 peptide | 分子名称: | H3K79me3, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | 著者 | Zeng, H, Amaya, M.F, Tempel, W, Walker, J.R, Mackenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-01-28 | 公開日 | 2011-02-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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3QKJ
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![BU of 3qkj by Molmil](/molmil-images/mine/3qkj) | The PWWP domain of human DNA (CYTOSINE-5-)-METHYLTRANSFERASE 3 BETA in complex with a bis-tris molecule | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA cytosine-5 methyltransferase 3 beta isoform 6 variant, SULFATE ION | 著者 | Zeng, H, Amaya, M.F, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-02-01 | 公開日 | 2011-03-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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8HC0
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![BU of 8hc0 by Molmil](/molmil-images/mine/8hc0) | Crystal structure of the extracellular domains of GPR110 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G-protein coupled receptor F1, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Wang, F.F, Song, G.J. | 登録日 | 2022-11-01 | 公開日 | 2023-09-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal Structure of the Extracellular Domains of GPR110. J.Mol.Biol., 435, 2023
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6KC0
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![BU of 6kc0 by Molmil](/molmil-images/mine/6kc0) | fused To-MtbCsm1 with 2ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A),CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), MAGNESIUM ION | 著者 | Li, T, Huo, Y, Jiang, T. | 登録日 | 2019-06-26 | 公開日 | 2020-07-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | 主引用文献 | Mycobacterium tuberculosis CRISPR/Cas system Csm1 holds clues to the evolutionary relationship between DNA polymerase and cyclase activity. Int.J.Biol.Macromol., 170, 2020
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6IN8
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![BU of 6in8 by Molmil](/molmil-images/mine/6in8) | Crystal structure of MucB | 分子名称: | Sigma factor AlgU regulatory protein MucB | 著者 | Li, S, Zhang, Q, Bartlam, M. | 登録日 | 2018-10-24 | 公開日 | 2019-07-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa. Febs J., 286, 2019
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6IH0
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![BU of 6ih0 by Molmil](/molmil-images/mine/6ih0) | Aquifex aeolicus LpxC complex with ACHN-975 | 分子名称: | N-[(2S)-3-azanyl-3-methyl-1-(oxidanylamino)-1-oxidanylidene-butan-2-yl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta -1,3-diynyl]benzamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, ... | 著者 | Li, D.Y, Fan, S, Jin, Y.Y, Zhang, C, Lv, G.X, Wu, G.T, Yang, Z.Y. | 登録日 | 2018-09-27 | 公開日 | 2019-01-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | 主引用文献 | The Complex Structure of Protein AaLpxC from Aquifex aeolicus with ACHN-975 Molecule Suggests an Inhibitory Mechanism at Atomic-Level against Gram-Negative Bacteria Molecules, 26, 2021
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6IN9
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6IN7
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![BU of 6in7 by Molmil](/molmil-images/mine/6in7) | |
5XSU
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![BU of 5xsu by Molmil](/molmil-images/mine/5xsu) | novel orally efficacious inhibitors complexed with PARP1 | 分子名称: | 6-fluoranyl-2-(4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | 著者 | Liu, Q, Xu, Y. | 登録日 | 2017-06-15 | 公開日 | 2018-04-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors Eur J Med Chem, 145, 2018
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6J9M
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![BU of 6j9m by Molmil](/molmil-images/mine/6j9m) | NmeBH+AcrIIC2 | 分子名称: | AcrIIC2, CRISPR-associated endonuclease Cas9 | 著者 | Zhu, Y.L, Gao, A, Serganov, A, Gao, P. | 登録日 | 2019-01-23 | 公開日 | 2019-03-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.394 Å) | 主引用文献 | Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. Mol. Cell, 74, 2019
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6J9K
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![BU of 6j9k by Molmil](/molmil-images/mine/6j9k) | Apo-AcrIIC2 | 分子名称: | AcrIIC2, MAGNESIUM ION | 著者 | Zhu, Y.L, Gao, A, Serganov, A, Gao, P. | 登録日 | 2019-01-23 | 公開日 | 2019-03-06 | 最終更新日 | 2022-03-23 | 実験手法 | X-RAY DIFFRACTION (2.234 Å) | 主引用文献 | Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. Mol. Cell, 74, 2019
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