7JVN
 
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7JVM
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6M4J
 | | SspA in complex with cysteine | | 分子名称: | CYSTEINE, PYRIDOXAL-5'-PHOSPHATE, SspA complex protein | | 著者 | Liu, L, Gao, H. | | 登録日 | 2020-03-07 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Analysis of an l-Cysteine Desulfurase from an Ssp DNA Phosphorothioation System.
Mbio, 11, 2020
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6NUK
 | | De novo designed protein Ferredog-Diesel | | 分子名称: | Ferredog-Diesel | | 著者 | Koepnick, B, Bick, M.J, DiMaio, F, Norgard-Solano, T, Baker, D. | | 登録日 | 2019-02-01 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | De novo protein design by citizen scientists.
Nature, 570, 2019
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5E37
 | | Redox protein from Chlamydomonas reinhardtii | | 分子名称: | CALCIUM ION, EF-Hand domain-containing thioredoxin | | 著者 | Charoenwattansatien, R, Hochmal, A.K, Zinzius, K, Muto, R, Tanaka, H, Hippler, M, Kurisu, G. | | 登録日 | 2015-10-02 | | 公開日 | 2016-06-22 | | 最終更新日 | 2020-02-19 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Calredoxin represents a novel type of calcium-dependent sensor-responder connected to redox regulation in the chloroplast
Nat Commun, 7, 2016
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6AGG
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8OUS
 | | CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 19 | | 分子名称: | (1S)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2-methyl-propan-1-ol, Mitogen-activated protein kinase kinase kinase 12 | | 著者 | Zebisch, M, McEwan, P.A, Barker, J.J, Cross, J.B. | | 登録日 | 2023-04-24 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
J.Med.Chem., 66, 2023
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8OUR
 | | CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 16 | | 分子名称: | 5-[1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)-2-propan-2-yl-imidazol-4-yl]-3-(trifluoromethyloxy)pyridin-2-amine, Mitogen-activated protein kinase kinase kinase 12 | | 著者 | Zebisch, M, McEwan, P.A, Barker, J.J, Cross, J.B. | | 登録日 | 2023-04-24 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
J.Med.Chem., 66, 2023
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8OUT
 | | CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 22 | | 分子名称: | (1R)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-fluoranyl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2,2,2-tris(fluoranyl)ethanol, Mitogen-activated protein kinase kinase kinase 12 | | 著者 | Zebisch, M, Akkermans, O, Barker, J.J, Cross, J.B. | | 登録日 | 2023-04-24 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.935 Å) | | 主引用文献 | Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
J.Med.Chem., 66, 2023
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3V5Q
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5TRV
 | | Crystal structure of a de novo designed protein with curved beta-sheet | | 分子名称: | DI(HYDROXYETHYL)ETHER, denovo NTF2 | | 著者 | Basanta, B, Oberdorfer, G, Marcos, E, Chidyausiku, T.M, Sankaran, B, Baker, D. | | 登録日 | 2016-10-27 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
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5TPH
 | | Crystal structure of a de novo designed protein homodimer with curved beta-sheet | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, de novo NTF2 homodimer | | 著者 | Basanta, B, Marcos, E, Oberdorfer, G, Chidyausiku, T.M, Sankaran, B, Baker, D. | | 登録日 | 2016-10-20 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
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5TS4
 | | Crystal structure of a de novo designed protein with curved beta-sheet | | 分子名称: | DI(HYDROXYETHYL)ETHER, denovo NTF2 | | 著者 | Basanta, B, Oberdorfer, G, Chidyausiku, T.M, Marcos, E, Pereira, J.H, Sankaran, B, Zwart, P.H, Baker, D. | | 登録日 | 2016-10-27 | | 公開日 | 2017-01-25 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (3.005 Å) | | 主引用文献 | Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
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5TPJ
 | | Crystal structure of a de novo designed protein with curved beta-sheet | | 分子名称: | denovo NTF2 | | 著者 | Basanta, B, Oberdorfer, G, Marcos, E, Chidyausiku, T.M, Sankaran, B, Baker, D. | | 登録日 | 2016-10-20 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.101 Å) | | 主引用文献 | Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
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7F9W
 | | CD25 in complex with Fab | | 分子名称: | Heavy chain of Fab, Interleukin-2 receptor subunit alpha, Light chain of Fab | | 著者 | Liu, C. | | 登録日 | 2021-07-05 | | 公開日 | 2022-01-12 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity.
Sci Rep, 11, 2021
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5U35
 | | Crystal structure of a de novo designed protein with curved beta-sheet | | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-METHOXYETHANOL, CHLORIDE ION, ... | | 著者 | Oberdorfer, G, Marcos, E, Basanta, B, Chidyausiku, T.M, Sankaran, B, Zwart, P.H, Baker, D. | | 登録日 | 2016-12-01 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
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6MD7
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4YPI
 | | Structure of Ebola virus nucleoprotein N-terminal fragment bound to a peptide derived from Ebola VP35 | | 分子名称: | Nucleoprotein, Polymerase cofactor VP35 | | 著者 | Leung, D.W, Borek, D.M, Binning, J.M, Otwinowski, Z, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2015-03-13 | | 公開日 | 2015-04-08 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (3.71 Å) | | 主引用文献 | An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.
Cell Rep, 11, 2015
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6MDB
 | | Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrazolo-pyrimidinone 5 | | 分子名称: | 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)-5-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Fodor, M, Stams, T. | | 登録日 | 2018-09-04 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
J. Med. Chem., 62, 2019
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5TQH
 | | IDH1 R132H mutant in complex with IDH889 | | 分子名称: | (4S)-3-[2-({(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl}amino)pyrimidin-4-yl]-4-(propan-2-yl)-1,3-oxazolidin-2-one, CITRATE ANION, Isocitrate dehydrogenase [NADP] cytoplasmic, ... | | 著者 | Xie, X, Kulathila, R. | | 登録日 | 2016-10-24 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.
ACS Med Chem Lett, 8, 2017
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4DDS
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4DE0
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7JQ8
 | | Solution NMR structure of human Brd3 ET domain | | 分子名称: | Bromodomain-containing protein 3, Integrase peptide | | 著者 | Aiyer, S, Swapna, G.V.T, Roth, J.M, Montelione, G.T. | | 登録日 | 2020-08-10 | | 公開日 | 2021-06-23 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.
Structure, 29, 2021
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7JMY
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7JYN
 | | Solution NMR structure of human Brd3 ET complexed with NSD3(148-184) peptide | | 分子名称: | Bromodomain-containing protein 3, Histone-lysine N-methyltransferase NSD3 | | 著者 | Aiyer, S, Swapna, G.V.T, Roth, M.J, Montelione, G.T. | | 登録日 | 2020-08-31 | | 公開日 | 2021-06-23 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.
Structure, 29, 2021
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