7C2J
| Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (without additional SAM during crystallization) | 分子名称: | 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... | 著者 | Lin, S, Chen, H, Ye, F, Chen, Z.M, Yang, F.L, Zheng, Y, Cao, Y, Qiao, J.X, Yang, S.Y, Lu, G.W. | 登録日 | 2020-05-07 | 公開日 | 2020-05-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | 主引用文献 | Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design. Signal Transduct Target Ther, 5, 2020
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7C2I
| Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with additional SAM during crystallization) | 分子名称: | 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... | 著者 | Lin, S, Chen, H, Ye, F, Chen, Z.M, Yang, F.L, Zheng, Y, Cao, Y, Qiao, J.X, Yang, S.Y, Lu, G.W. | 登録日 | 2020-05-07 | 公開日 | 2020-05-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design. Signal Transduct Target Ther, 5, 2020
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2JR7
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8GYA
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8GY9
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8GYB
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8GY4
| Crystal structure of Alongshan virus methyltransferase | 分子名称: | Methyltransferase | 著者 | Chen, H, Lin, S, Lu, G.W. | 登録日 | 2022-09-21 | 公開日 | 2023-09-27 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses. Plos Pathog., 19, 2023
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6OVB
| Crystal structure of a Bacillus thuringiensis Cry1Da tryptic core variant | 分子名称: | Active core crystal toxin protein 1D | 著者 | Rydel, T.J, Halls, C, Evdokimov, A.G, Beishir, S.C. | 登録日 | 2019-05-07 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.611 Å) | 主引用文献 | Bacillus thuringiensis Cry1Da_7 and Cry1B.868 Protein Interactions with Novel Receptors Allow Control of Resistant Fall Armyworms, Spodoptera frugiperda (J.E. Smith). Appl.Environ.Microbiol., 85, 2019
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7DIY
| Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-exoribonuclease domain | 分子名称: | MAGNESIUM ION, ZINC ION, nsp10 protein, ... | 著者 | Lin, S, Chen, H, Chen, Z.M, Yang, F.L, Ye, F, Zheng, Y, Yang, J, Lin, X, Sun, H.L, Wang, L.L, Wen, A, Cao, Y, Lu, G.W. | 登録日 | 2020-11-19 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.693 Å) | 主引用文献 | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity. Nucleic Acids Res., 49, 2021
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6OWK
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7X4B
| Crystal Structure of An Anti-CRISPR Protein | 分子名称: | Anti-CRISPR protein (AcrIIC1), SULFATE ION | 著者 | Hu, J, Zhang, S, Gao, J.Y, Liu, X, Liu, J. | 登録日 | 2022-03-02 | 公開日 | 2022-10-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1. Nat Commun, 13, 2022
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3EE5
| Crystal structure of human M340H-Beta1,4-Galactosyltransferase-I (M340H-B4GAL-T1) in complex with GLCNAC-Beta1,3-Gal-Beta-Naphthalenemethanol | 分子名称: | 1,4-DIETHYLENE DIOXIDE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, ... | 著者 | Ramakrishnan, B, Qasba, P.K. | 登録日 | 2008-09-04 | 公開日 | 2009-01-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Deoxygenated Disaccharide Analogs as Specific Inhibitors of {beta}1-4-Galactosyltransferase 1 and Selectin-mediated Tumor Metastasis J.Biol.Chem., 284, 2009
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3FLL
| Crystal structure of E55Q mutant of nitrophorin 4 | 分子名称: | AMMONIA, Nitrophorin-4, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Montfort, W.R, Weichsel, A. | 登録日 | 2008-12-18 | 公開日 | 2009-02-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes. J.Am.Chem.Soc., 131, 2009
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7CKG
| Crystal structure of TMSiPheRS complexed with TMSiPhe | 分子名称: | 4-(trimethylsilyl)-L-phenylalanine, Tyrosine--tRNA ligase | 著者 | Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P. | 登録日 | 2020-07-17 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | 主引用文献 | DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe. Nat Commun, 11, 2020
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7CKH
| Crystal structure of TMSiPheRS | 分子名称: | Tyrosine--tRNA ligase | 著者 | Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P. | 登録日 | 2020-07-17 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.79492676 Å) | 主引用文献 | DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe. Nat Commun, 11, 2020
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6LU5
| Crystal structure of BPTF-BRD with ligand DCBPin5 bound | 分子名称: | 6-(1H-indol-5-yl)-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF | 著者 | Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C. | 登録日 | 2020-01-25 | 公開日 | 2021-04-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.86527729 Å) | 主引用文献 | Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins To Be Published
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6LU6
| Crystal structure of BPTF-BRD with ligand DCBPin5-2 bound | 分子名称: | 6-[1-[3-(dimethylamino)propyl]indol-5-yl]-2-methylsulfonyl-N-propyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF | 著者 | Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C. | 登録日 | 2020-01-26 | 公開日 | 2021-04-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.970063 Å) | 主引用文献 | Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins To Be Published
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6JKM
| Crystal structure of BubR1 kinase domain | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Lin, L, Ye, S, Huang, Y, Liu, X, Zhang, R, Yao, X. | 登録日 | 2019-03-01 | 公開日 | 2019-06-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res., 29, 2019
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6JKK
| Crystal structure of BubR1 kinase domain | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Mitotic checkpoint control protein kinase BUB1 | 著者 | Lin, L, Ye, S, Huang, Y, Liu, X, Zhang, R, Yao, X. | 登録日 | 2019-03-01 | 公開日 | 2019-06-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res., 29, 2019
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7BZJ
| The Discovery of Benzhydrol-Oxaborole Hybrid Derivatives as Leucyl-tRNA Synthetase Inhibitors | 分子名称: | Leucine--tRNA ligase, [(1~{R},5~{R},6~{S},8~{R})-8-(6-aminopurin-9-yl)-4'-[(~{R})-oxidanyl-[4-(2-oxidanylidenepropylsulfanyl)phenyl]methyl]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,7'-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]-6-yl]methoxy-tris(oxidanyl)phosphanium | 著者 | Liu, R.J, Li, H, Wang, E.D, Zhou, H. | 登録日 | 2020-04-28 | 公開日 | 2020-12-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors. Bioorg.Med.Chem., 29, 2021
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7BP3
| Cryo-EM structure of the human MCT2 | 分子名称: | Monocarboxylate transporter 2 | 著者 | Zhang, B, Jin, Q, Zhang, X, Guo, J, Ye, S. | 登録日 | 2020-03-21 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun, 11, 2020
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7BOZ
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7BOY
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7BP0
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7BOX
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