1KVX
 
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1KVY
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1OSA
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4AQL
 | | HUMAN GUANINE DEAMINASE IN COMPLEX WITH VALACYCLOVIR | | 分子名称: | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate, GUANINE DEAMINASE, ZINC ION | | 著者 | Welin, M, Egeblad, L, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Graslund, S, Hammarstrom, M, Johansson, I, Karlberg, T, Kotenyova, T, Moche, M, Nyman, T, Persson, C, Schuler, H, Thorsell, A.G, Tresaugues, L, Weigelt, J, Nordlund, P. | | 登録日 | 2012-04-18 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Pan-Pathway Based Interaction Profiling of Fda-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism.
Plos One, 7, 2012
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1MKV
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2QK4
 | | Human glycinamide ribonucleotide synthetase | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, GLYCEROL, ... | | 著者 | Lehtio, L, Welin, M, Arrowsmith, C.H, Berglund, H, Busam, R, Collins, R, Dahlgren, L.G, Herman, M.D, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg-Schiavone, L, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Moche, M, Nyman, T, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Nordlund, P, Structural Genomics Consortium (SGC) | | 登録日 | 2007-07-10 | | 公開日 | 2007-07-24 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural studies of tri-functional human GART.
Nucleic Acids Res., 38, 2010
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1MKT
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1PK2
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1MKU
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4J5C
 | | Human Cyclophilin D Complexed with an Inhibitor | | 分子名称: | 1-(4-aminobenzyl)-3-[(2S)-4-(methylsulfanyl)-1-{(2R)-2-[2-(methylsulfanyl)phenyl]pyrrolidin-1-yl}-1-oxobutan-2-yl]urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | | 登録日 | 2013-02-08 | | 公開日 | 2014-02-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
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4J5E
 | | Human Cyclophilin D Complexed with an Inhibitor | | 分子名称: | 1-(4-aminobenzyl)-3-{2-[(2R)-2-(2-methoxyphenyl)pyrrolidin-1-yl]-2-oxoethyl}urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | | 登録日 | 2013-02-08 | | 公開日 | 2014-02-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (0.99 Å) | | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
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4J5B
 | | Human Cyclophilin D Complexed with an Inhibitor | | 分子名称: | 1-(4-aminobenzyl)-3-(2-{(2R)-2-[2-(methylsulfanyl)phenyl]pyrrolidin-1-yl}-2-oxoethyl)urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | | 登録日 | 2013-02-08 | | 公開日 | 2014-02-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
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4J5D
 | | Human Cyclophilin D Complexed with an Inhibitor | | 分子名称: | 1-(4-aminobenzyl)-3-{2-[(2R)-2-(2-bromophenyl)pyrrolidin-1-yl]-2-oxoethyl}urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | | 登録日 | 2013-02-08 | | 公開日 | 2014-02-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
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4J59
 | | Human Cyclophilin D Complexed with an Inhibitor | | 分子名称: | 1-(4-aminobenzyl)-3-{2-[(2R)-2-(naphthalen-1-yl)pyrrolidin-1-yl]-2-oxoethyl}urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial | | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | | 登録日 | 2013-02-08 | | 公開日 | 2014-02-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
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4J5A
 | | Human Cyclophilin D Complexed with an Inhibitor | | 分子名称: | 1-(4-aminobenzyl)-3-{2-[(2R)-2-(2,5-dimethoxyphenyl)pyrrolidin-1-yl]-2-oxoethyl}urea, DIMETHYL SULFOXIDE, Peptidyl-prolyl cis-trans isomerase F, ... | | 著者 | Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F. | | 登録日 | 2013-02-08 | | 公開日 | 2014-02-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Rationnal Design of small-molecule inhibitors of human Cyclophilins and HCV replication.
to be published
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1IRB
 | | CARBOXYLIC ESTER HYDROLASE | | 分子名称: | CALCIUM ION, PHOSPHOLIPASE A2 | | 著者 | Sundaralingam, M. | | 登録日 | 1997-08-13 | | 公開日 | 1997-12-24 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface.
Biochemistry, 35, 1996
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3QYW
 | | Crystal structure of ERK2 in complex with an inhibitor | | 分子名称: | 6-(3-bromophenyl)-7H-purin-2-amine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | | 著者 | Gelin, M, Pochet, S, Hoh, F, Pirochi, M, Guichou, J.-F, Ferrer, J.-L, Labesse, G. | | 登録日 | 2011-03-04 | | 公開日 | 2011-08-24 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.
Acta Crystallogr.,Sect.D, 67, 2011
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3QYZ
 | | Crystal structure of ERK2 in complex with an inhibitor | | 分子名称: | 5'-azido-8-bromo-5'-deoxyadenosine, BETA-MERCAPTOETHANOL, DIMETHYL SULFOXIDE, ... | | 著者 | Gelin, M, Pochet, S, Hoh, F, Pirochi, M, Guichou, J.-F, Ferrer, J.-L, Labesse, G. | | 登録日 | 2011-03-04 | | 公開日 | 2011-08-24 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.
Acta Crystallogr.,Sect.D, 67, 2011
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4APA
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4APB
 | | Crystal structure of Mycobacterium tuberculosis fumarase (Rv1098c) S318C in complex with fumarate | | 分子名称: | CALCIUM ION, FUMARATE HYDRATASE CLASS II, FUMARIC ACID | | 著者 | Bellinzoni, M, Haouz, A, Mechaly, A.E, Alzari, P.M. | | 登録日 | 2012-03-31 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
FEBS Lett., 586, 2012
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2O79
 | | T4 lysozyme with C-terminal extension | | 分子名称: | CHLORIDE ION, GLYCEROL, Lysozyme, ... | | 著者 | Llinas, M, Crowder, S.M, Echols, N, Alber, T, Marqusee, S. | | 登録日 | 2006-12-10 | | 公開日 | 2007-04-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Exploring subdomain cooperativity in T4 lysozyme I: Structural and energetic studies of a circular permutant and protein fragment.
Protein Sci., 16, 2007
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2O4W
 | | T4 lysozyme circular permutant | | 分子名称: | CHLORIDE ION, Lysozyme | | 著者 | Llinas, M, Crowder, S.M, Echols, N, Alber, T, Marqusee, S. | | 登録日 | 2006-12-05 | | 公開日 | 2007-04-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Exploring subdomain cooperativity in T4 lysozyme I: Structural and energetic studies of a circular permutant and protein fragment.
Protein Sci., 16, 2007
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2XIW
 | | Crystal structure of the Sac7d-derived IgG1-binder C3-C24S | | 分子名称: | CHLORIDE ION, DNA-BINDING PROTEIN 7D, SULFATE ION | | 著者 | Bellinzoni, M, Colinet, S, Behar, G, Alzari, P.M, Pecorari, F. | | 登録日 | 2010-07-01 | | 公開日 | 2011-07-13 | | 最終更新日 | 2013-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Tolerance of the Archaeal Sac7D Scaffold Protein to Alternative Library Designs: Characterization of Anti-Immunoglobulin G Affitins.
Protein Eng.Des.Sel., 26, 2013
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2BPP
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2WAM
 | | Crystal structure of Mycobacterium tuberculosis unknown function protein Rv2714 | | 分子名称: | CONSERVED HYPOTHETICAL ALANINE AND LEUCINE RICH PROTEIN, GLYCEROL | | 著者 | Bellinzoni, M, Grana, M, Buschiazzo, A, Miras, I, Haouz, A, Alzari, P.M. | | 登録日 | 2009-02-09 | | 公開日 | 2009-10-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of Mycobacterium Tuberculosis Rv2714, a Representative of a Duplicated Gene Family in Actinobacteria.
Acta Crystallogr.,Sect.F, 65, 2009
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