4AQL

HUMAN GUANINE DEAMINASE IN COMPLEX WITH VALACYCLOVIR

Summary for 4AQL

Entry DOI	10.2210/pdb4aql/pdb
Related	2UZ9
Descriptor	GUANINE DEAMINASE, ZINC ION, 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate, ... (4 entities in total)
Functional Keywords	hydrolase, purine metabolism
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	54010.30
Authors	Welin, M.,Egeblad, L.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nyman, T.,Persson, C.,Schuler, H.,Thorsell, A.G.,Tresaugues, L.,Weigelt, J.,Nordlund, P. (deposition date: 2012-04-18, release date: 2012-05-02, Last modification date: 2023-12-20)
Primary citation	Egeblad, L.,Welin, M.,Flodin, S.,Graslund, S.,Wang, L.,Balzarini, J.,Eriksson, S.,Nordlund, P. Pan-Pathway Based Interaction Profiling of Fda-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism. Plos One, 7:37724-, 2012 Cited by PubMed: 22662200 DOI: 10.1371/JOURNAL.PONE.0037724 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation